DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc4a

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_001276811.1	Gene:	trpc4a / 102725537	ZFINID:	ZDB-GENE-131217-1	Length:	934	Species:	Danio rerio

Alignment Length:	991	Identity:	387/991 - (39%)
Similarity:	550/991 - (55%)	Gaps:	137/991 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 MMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLM 86
            ::..|..||.:||.::.:.|:||...||:.|.|.:...|.||||.||:.|:||:.||||||.:::
Zfish    22 IVRSESELSPLEKAYLWAVEKGDYGSVKQALIEAEIYFKININCIDPLGRTALLIAIENENLEII 86

  Fly    87 VILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKE---GQPYSWEAVDRSKSTFTVDITPL 148
            .:||..|:.|||||||||.:|.|.|||.||     |||:   |.......:|:..|.||.||||:
Zfish    87 ELLLSFNVYVGDALLHAIRKEVVGAVELLL-----NHKKPSGGMQVPPILLDKQFSDFTPDITPI 146

  Fly   149 ILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIAL 213
            |||||.|||||:|:|:.:|.::|.||.|:|.|.|||:|...||||||:||:|.||||::.||:||
Zfish   147 ILAAHTNNYEIIKMLVQKGVSMPQPHQVRCNCMECVSSSDVDSLRHSRSRLNIYRALASPSLVAL 211

  Fly   214 SSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEPS 278
            ||.||.||||||||||:.|..:|:||::||.|:.|..:.|...|||..|:|.|||::||:    .
Zfish   212 SSEDPFLTAFQLSWELQELSKVENEFKSEYEELSQQCKQFAKDLLDQTRSSRELELILNY----K 272

  Fly   279 HDIWCLGQR--QTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLG 341
            .||..|...  ..|.||||||:|.||.|||.||.|||||:.|||..||:||:..:.:.|..:.:|
Zfish   273 DDINLLEDEGINDLARLKLAIKYHQKEFVAQPNCQQLLASRWYDEFPGWRRRHWASKFMTCIFIG 337

  Fly   342 CSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLT 406
            ..||.:||.|::||.|....|:||||:|||.|:.||:.||.||..||..|.:...:
Zfish   338 LLFPFFSLFYLIAPKSHYGLFIRKPFIKFICHTASYLTFLFLLLLASQHVNRNLLD--------- 393

  Fly   407 MLEDWR---KHE--RGSL-PGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYISNMF 465
              :|..   |:|  |.:| |..:|..|:.:::..::.|:|.::..|..:||.|.||::|::.|..
Zfish   394 --QDENSDCKNENLRQNLAPTTVEWMILPWVLGFVWAEIKQMWDGGFQDYIHDWWNLMDFVMNSL 456

  Fly   466 YVTWILCRATAWVIVH---RDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFS 527
            |:..|..:..|....:   ||.|          :.||   |.|:.|..||...:||.|:|:.:|:
Zfish   457 YLATISLKIVALSKYNNQCRDEW----------DMWH---PALVGEALFAIANIFSSLRLISLFT 508

  Fly   528 INPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKN---------KCYHLH 583
            .|.||||||:|||||::||:||.|||.|||.||..|||||.:||....|.         :|
Zfish   509 ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYESDGKTSNNVTCKGIRC---- 569

  Fly   584 PDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVI 648
                  .:|..|      |:.:|||.|||||:.||||.|...::.....||.|....|||:||:|
Zfish   570 ------SEQNNA------FTTMFETLQSLFWSIFGLVALHVTNVDAKHDFTEFVGATMFGTYSII 622

  Fly   649 NIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMK----MLR- 708
            :::||||||||||:||||.|::.||.||||||::|||||||:|||:|||||:.|:.|    ::|
Zfish   623 SLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNVVPSPKSAWYLIRW 687

  Fly   709 ------KTLGRKRPSRTKSFMRKSMERAQT--LHDKVMKLLVRRYITAEQR-RRDDYGITEDDII 764
                  |...|||.....|...::.|..:|  .:.:|::.||:||:.|..| .:.:.|:|||:..
Zfish   688 IKTHCFKIKQRKRTETLGSLGIRAAENVRTNXQYQEVLRNLVKRYVAARIRDAKKEEGLTEDNFK 752

  Fly   765 EVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVEN-LKQEMS 828
            |::|||||.|:|::.:.           |.::....|:||..      .|..:.:.|| ||...:
Zfish   753 ELKQDISSFRYEVMGMM-----------KGTKTGMSTSKGNT------ADSSLVYPENALKCNST 800

  Fly   829 ESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASDPIGSKRSSMQRH------------- 880
            .:.|.......|..:......:.|.|.|......| .|...:.:|..|.|.:
Zfish   801 STGSTLKGKMRLQSITNTMIQEGGPKAWKPTGCSN-LADSSVPNKTISHQLNCKGPNNPGEMYSV 864

  Fly   881 SQRSLRRKIIEQAN----EGL----QMNQTQLIEFNPNLGDVTRATRVAYVKFMRKKMAADEVSL 937
            |:.:...:..||.:    |.|    :.||.:..|.:....||.....:.|:::|
Zfish   865 SEEAGESESEEQGDGKQAENLDCKKKKNQNKETEKDGVNNDVEEDEELTYMRYM----------- 918

  Fly   938 ADDEGAPNGEGEKKPL 953
            .::|.....|||...|
Zfish   919 CEEEMNEGNEGETSRL 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	350/790 (44%)
		ANK	64..>168	CDD:238125	56/106 (53%)
		ANK repeat	69..98	CDD:293786	13/28 (46%)
		ANK repeat	99..135	CDD:293786	17/38 (45%)
		ANK repeat	137..168	CDD:293786	19/30 (63%)
		TRP_2	178..236	CDD:285535	38/57 (67%)
		BASP1	938..1158	CDD:283191	5/16 (31%)
trpc4a	NP_001276811.1	trp	17..764	CDD:273311	350/790 (44%)
		ANK	35..162	CDD:238125	65/131 (50%)
		ANK repeat	70..98	CDD:293786	13/27 (48%)
		ANK repeat	99..133	CDD:293786	17/38 (45%)
		ANK repeat	135..166	CDD:293786	19/30 (63%)
		TRP_2	176..235	CDD:285535	38/58 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581925
Domainoid	1	1.000	270	1.000	Domainoid score	I1782
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm6331
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.800