DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc4b

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_001276810.1	Gene:	trpc4b / 102725536	ZFINID:	ZDB-GENE-120329-1	Length:	915	Species:	Danio rerio

Alignment Length:	1002	Identity:	393/1002 - (39%)
Similarity:	559/1002 - (55%)	Gaps:	185/1002 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIEN 80
            |:...::.||.. ||..||:::.:.|:||...||..|||.:...|.||||.||:.|:||:.||||
Zfish    17 RIPLRIVRAESE-LSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIEN 80

  Fly    81 ENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAV-----DRSKST 140
            ||.:::.:||..|:.|||||||||.:|.|.|||.||     |||  :|...:.|     |:..|.
Zfish    81 ENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLL-----NHK--KPSGEKQVPPILLDKQFSD 138

  Fly   141 FTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRAL 205
            ||.||||:|||||.|||||:|:|:.:|.::|.||:|:|.|.|||:|...||||||:||:|.|:||
Zfish   139 FTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKAL 203

  Fly   206 SASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVM 270
            ::.|||||||.||.||||||||||:.|..:|:||:|||.|:....:.|...|||..|:|.|||::
Zfish   204 ASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELI 268

  Fly   271 LNFNHEPSHDIWCLGQRQT---LERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332
            |||..:.:     |.|.:.   |.||||||:|:||.|||.||.|||||:.|||..||:||:..:.
Zfish   269 LNFRDDMN-----LLQDEANNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAG 328

  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFE 397
            :|:..|.:|..||:.||.|::||.|....|:||||:|||.|:.||:.||.||..||..:|..
Zfish   329 KLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVSN--- 390

  Fly   398 LLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYIS 462
                          ....:|..|..:|..|:.:::..|:.|:|.::..|..:||.|.||::|::.
Zfish   391 --------------NPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVM 441

  Fly   463 NMFYVTWILCRATAWV----IVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLV 523
            |..|:..|..:..|:|    ...||.|          |.||   |.|::|..||...:||.|:|:
Zfish   442 NSLYLATISLKIVAYVKYSGCKPRDTW----------EMWH---PTLVAEAVFAIANIFSSLRLI 493

  Fly   524 HIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVAD 588
            .:|:.|.||||||:|||||::||:||.|||.|||.||..|||||.:||...|...|..:.
Zfish   494 SLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIR----- 553

  Fly   589 FDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVL 653
            .:.|..|      ||.||||.|||||:.|||:.|...::.....||.|....|||:|:||:::||
Zfish   554 CERQNNA------FSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVL 612

  Fly   654 LNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMK-------MLRKTL 711
            ||||||||:||||.|::.||.||||||::|||||||:|||:|||||:.|:.|       .::..:
Zfish   613 LNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHV 677

  Fly   712 GRKRPSRTKSF---MRKSMERAQTLH--DKVMKLLVRRYITAEQR-RRDDYGITEDDIIEVRQDI 770
            .::|..||::|   .|::.|..:..|  .:|::.||:||:.|..| .:.:.|:||::..|::|||
Zfish   678 FKRRSKRTETFGTLGRRAAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDI 742

  Fly   771 SSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMSESESGRD 835
            ||.|:|::.:...|
Zfish   743 SSFRYEVIGMMKGN--------------------------------------------------- 756

  Fly   836 IFSSLAKVIGRKKTQKGDKDWNAIARKNTFASD---PIGSKR--SSMQRHSQ-------RSLRRK 888
                      ||.|:....|        |.|||   |.||.:  |:::::|:       .:|:::
Zfish   757 ----------RKSTRANKSD--------TSASDVSHPEGSLQYSSALKQNSKLHLYDVTTALQQQ 803

  Fly   889 IIEQANE--GLQMNQTQLIEFNPNLGDVTRATRVAYVK-------FMRKKMAADEVSLADD--EG 942
            ..|:|..  |...|.:.::...|.|.|..|:.   :.|       |.:|:......|||::  |.
Zfish   804 NSEEAKASLGCLANGSAVVLTEPILKDKARSD---FPKDFTDFGLFPKKQNPNKIYSLAEEATES 865

  Fly   943 APN----GEGEKKPL------DASGSK 959
            .|:    |: |.|||      |.:.||
Zfish   866 DPDILDWGK-EDKPLAGKVEQDVNESK 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	353/784 (45%)
		ANK	64..>168	CDD:238125	57/108 (53%)
		ANK repeat	69..98	CDD:293786	13/28 (46%)
		ANK repeat	99..135	CDD:293786	18/40 (45%)
		ANK repeat	137..168	CDD:293786	19/30 (63%)
		TRP_2	178..236	CDD:285535	38/57 (67%)
		BASP1	938..1158	CDD:283191	11/34 (32%)
trpc4b	NP_001276810.1	trp	17..748	CDD:273311	353/784 (45%)
		ANK repeat	70..98	CDD:293786	13/27 (48%)
		ANK repeat	99..133	CDD:293786	18/40 (45%)
		ANK repeat	135..166	CDD:293786	19/30 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581924
Domainoid	1	1.000	270	1.000	Domainoid score	I1782
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm6331
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900