Protein Alignment trp and trpc6b

DIOPT Version :10

• Sequence 1: NP_476768.1
• Gene: trp / 43542
• FlyBaseID: FBgn0003861
• Length: 1275
• Species: Drosophila melanogaster
• Sequence 2: XP_002665445.3
• Gene: trpc6b / 102725535
• ZFINID: ZDB-GENE-081030-19
• Length: 858
• Species: Danio rerio
• Alignment Length: 862
• Identity: 296/862 - (34%)
• Similarity: 455/862 - (52%)
• Gaps: 139/862 - (16%)

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91
            ||..|:.|:.:.|.|::|.::::|||   ..:.|:||.|.|.::||..|:.||:.::..:||  |
Zfish    63 LSPTEERFLEAAEYGNIPVIRRMLEE---LPELNVNCVDYMGQNALQLAVANEHLEVTELLLKKE 124

  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQ---WEETNHKEGQPYSWE------AVDRSKSTFTVDITP 147
            :...:|||||.|||:.|:..||.:|.   :.:|......|...|      |.|...:.|:.||||
Zfish   125 NLARIGDALLLAISKGYIRIVEAILSHQAFADTTKLTSSPLQAETQDDFFAYDEDGTRFSHDITP 189

  Fly   148 LILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIA 212
            :|||:|.:.|||:.|||.:||.:..|||..|.|:.|:..|..||..||:||||||:.|::.:.::
Zfish   190 IILASHCHEYEIVHILLRKGARIARPHDYFCKCNGCLYHQRHDSFSHSRSRINAYKGLASPAYLS 254

  Fly   213 LSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHE- 276
            |||.||||||.:||.||..|..:|.||:.:|..:....:||...|||..|.:.|:|.:||.:.|
Zfish   255 LSSEDPVLTALELSNELAVLANIEKEFKNDYKTLSMQCKDFVVGLLDLCRNTEEVEAILNGDTEV 319

  Fly   277 PSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLG 341
            ..|  :..|.|..|.||||||:|:.|.||||||.||.|.:|||:.|.|.|::..:.:|:.|:.:.
Zfish   320 GGH--FDKGDRPNLVRLKLAIKYELKKFVAHPNCQQQLLSIWYENLSGLRQQTTAVKLLVVLGVV 382

  Fly   342 CSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLL---------GAASLRVVQI--- 394
            ...||.:|.|.:||.|:..|.:|.||:||:.|:.|:..||.||         |.:.|..:.:
Zfish   383 VGLPILALLYWIAPSSKLGKIIRGPFLKFVAHAASFTIFLGLLIMNAADRFEGTSLLPNMTVHDH 447

  Fly   395 -----TFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDL 454
                 ..:...|.||                   |:.||::::.:|:.|.|.::|.|..||:::.
Zfish   448 PSQLFRMKTTPFTWM-------------------EMLIISWVVGMIWAECKEIWSLGPREYLLEP 493

  Fly   455 WNIVDYISNMFYVTWILCRATAWVIVHRDLWFRGIDPYF-----------------PREHWHPFD 502
            ||::|:.....:||..:.|..|:  .|.::....:|..:                 .|.||.|.|
Zfish   494 WNLLDFGMLAIFVTSFIARFMAF--YHANVAQNYVDKRYTDLSNITLPLEIEYYRLARVHWVPSD 556

  Fly   503 PMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQL 567
            |.|:|||.:|..:|.|:.::.:|...|...||||:||||.:.||.||..|:.:|..||..|:..|
Zfish   557 PQLISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNL 621

  Fly   568 LWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKS 632
            ..||...::|..                      |:.:.|:.::||||.|||.::.|..:.....
Zfish   622 YSYYRGAKQNGA----------------------FTTVEESFKTLFWAIFGLSEVKSVVINNGHK 664

  Fly   633 FTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPP 697
            |......:::|.|:|..:||||||||||::||:|.|.:.||.||||||::||.||||:|||:|.|
Zfish   665 FIENIGYVLYGVYNVTMVIVLLNMLIAMINNSFQEIEDDADVEWKFARAKLWFSYFEEGGTLPVP 729

  Fly   698 FNLCPN--------MKMLRKTL-------------------GRKRPSRTKSFMRKSMERAQTLHD 735
            |||.|:        |::.|..|                   |:::.|..|:....|.      :.
Zfish   730 FNLIPSPKSVISLAMRLKRLLLIPLHRHKEDLKEDTELNESGKQKESSEKNSPHTSR------YQ 788

  Fly   736 KVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVAR 800
            ::||.|::||:...|..::...:.|.::.|::||||||||||||            ||..|....
Zfish   789 RIMKRLIKRYVIKAQTDKEGDEVNEGELKEIKQDISSLRFELLE------------EKSRQTEEL 841

  Fly   801 TTKGKVMERRILKDFQI 817
            ....:.:|.|::..::|
Zfish   842 AELVRRLEERLISQYKI 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	285/819 (35%)
		ANK repeat	69..98	CDD:293786	9/30 (30%)
		ANK repeat	99..135	CDD:293786	14/44 (32%)
		ANK repeat	137..168	CDD:293786	15/30 (50%)
		TRP_CaM_bind1	797..860	CDD:467881	3/21 (14%)
		PRK12323	<891..1102	CDD:481241
		PspC_subgroup_2	<1015..1156	CDD:468202
trpc6b	XP_002665445.3	None