DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc1

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	XP_002937145.3	Gene:	trpc1 / 100497011	XenbaseID:	XB-GENE-1004978	Length:	896	Species:	Xenopus tropicalis

Alignment Length:	814	Identity:	293/814 - (35%)
Similarity:	445/814 - (54%)	Gaps:	93/814 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNTESDAEKALGSRLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTD 67
            |...|...|.|..:   |:...:|....| |:.|:|:||:||...|||:||| ..:::.|||..|
Frog   125 STDSSSPNKFLALK---DVREVKEETTLD-ERLFLLACEKGDYYMVKKLLEE-NSSEELNINSVD 184

  Fly    68 PMNRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSW- 131
            .:.|:|:..:|||||.|::.:||.:..:..||||.||..|.|.||:.||     ||   || .|
Frog   185 VLGRNAITISIENENLDILQLLLNYGCQSTDALLVAIDSEVVGAVDILL-----NH---QP-KWR 240

  Fly   132 ---------EAVDRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQ 187
                     |.:...:.:.|:|:.|:||||||||||||.:||.:..:||.||.|.|.|..|....
Frog   241 TRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCTAKN 305

  Fly   188 MTDSLRHSQSRINAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQD 252
            ..||||||:.|::.||.|::.:||.|:..||:|.||:||.:||.|..:|.|||.:|.|:.|..:.
Frog   306 KKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELAQKCKT 370

  Fly   253 FGTSLLDHARTSMELEVMLNF--NHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLA 315
            |...||..||.|.||||:||.  :.||......|.:|..|.||||||:|.||.||:..|.||.|.
Frog   371 FAKDLLAQARNSRELEVILNHQSSDEPVDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLN 435

  Fly   316 AIWYDGLPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFF 380
            .:|:..:.|:|||...::::.|:.:|..:|:.|:.|:|||.|:..:.:..||:|||.|..||..|
Frog   436 TVWFGQMAGYRRKHTCKKILIVLTVGIFWPVLSVCYLLAPKSQVGRIIHTPFMKFIIHGASYFTF 500

  Fly   381 LMLLGAASLRVVQITFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSD 445
            |:||...||                 :..:.:|:..|.....|:..:|.:::.:::.::|.|:.|
Frog   501 LLLLNLYSL-----------------VYNEDKKNTMGPALERIDFLLIMWLIGMVWSDVKRLWYD 548

  Fly   446 GLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGA 510
            ||.:::.:..|.:.::.|..|:.....:    |:.|..  |..|   ..|:.|..|.|.|::||.
Frog   549 GLEDFLEESRNQLSFVMNSLYLATFALK----VVAHNK--FHSI---AERKDWDAFHPTLVAEGL 604

  Fly   511 FAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWY---YA 572
            ||.|.|.|||:|..:::.:..|||||:|:|:|:.|..||..::.||||:|..||.||  |   |.
Frog   605 FAFGNVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQL--YDKGYT 667

  Fly   573 ELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFT--- 634
            ..|:..|      |..|.:|:..    ..|.:...|..:|||..|.|..:..|    :..|:
Frog   668 TNEQKDC------VGIFCEQQSN----DAFHSFTGTCYALFWYIFSLAHVALF----VTRFSFSE 718

  Fly   635 ---RFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPP 696
               .|...|:.|:|:|:.:|||..:|:||:..|:|:|:...|.||||||::||:|||:|..|:||
Frog   719 ELQSFVGALIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPP 783

  Fly   697 PFNLCPNMKML-------------RKTLGR-KRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYIT 747
            |||:.|:.|.:             ..|.|| ||.:..|.:.....:|.:. :.|||..||.||:|
Frog   784 PFNIVPSPKTICYLFNSISKWICSHTTTGRVKRQNSLKEWKSLRQKRDEN-YQKVMCCLVHRYLT 847

  Fly   748 A-EQRRRDDYGITEDDIIEVRQDISSLRFELLEI 780
            : .|:.:.....|.:::.|:|||:|..|.|:.::
Frog   848 SMRQKMQSTDQATVENLNELRQDLSKFRNEMRDL 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	288/795 (36%)
		ANK	64..>168	CDD:238125	47/113 (42%)
		ANK repeat	69..98	CDD:293786	10/28 (36%)
		ANK repeat	99..135	CDD:293786	17/45 (38%)
		ANK repeat	137..168	CDD:293786	17/30 (57%)
		TRP_2	178..236	CDD:285535	26/57 (46%)
		BASP1	938..1158	CDD:283191
trpc1	XP_002937145.3	trp	151..877	CDD:273311	285/778 (37%)
trpc1	XP_002937145.3	ANK repeat	186..213	CDD:293786	10/26 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020