DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc4

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	XP_002939629.3	Gene:	trpc4 / 100485338	XenbaseID:	XB-GENE-1013618	Length:	969	Species:	Xenopus tropicalis

Alignment Length:	1017	Identity:	395/1017 - (38%)
Similarity:	572/1017 - (56%)	Gaps:	126/1017 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NTESDAEKALGSRLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDP 68
            ||.|..:..:..|:     :..|..||..||.::.:.|:||...||:.|||.:...|.||||.||
Frog     9 NTNSPYQDRIPLRI-----VRSESELSPSEKAYLSAVEKGDYASVKQALEEAEIYFKININCIDP 68

  Fly    69 MNRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEA 133
            :.|:||:.||||||.:|:.:||.:|:.|||||||||.:|.|.|||.||     |||  :|...:.
Frog    69 LGRTALLIAIENENLELIELLLSYNVYVGDALLHAIRKEVVGAVELLL-----NHK--KPSGEKQ 126

  Fly   134 V-----DRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLR 193
            |     |:..|.||.||||:|||||.|||||:|.|:.:|.::|.||:|:|.|.|||:....||||
Frog   127 VPPILLDKQFSEFTPDITPIILAAHTNNYEIIKHLVQKGVSVPRPHEVRCNCVECVSGSDVDSLR 191

  Fly   194 HSQSRINAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLL 258
            ||:||:|.|||||:.|||||||.||.||||||||||:.|..:|:||::||.|:....:.|...||
Frog   192 HSRSRLNIYRALSSPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSSQCKQFAKDLL 256

  Fly   259 DHARTSMELEVMLNFNHEPS--HDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDG 321
            |..|:|.|||::||:..:..  .|    .....|.||||||:|:||.|||.||.|||||:.|||.
Frog   257 DQTRSSRELEIILNYRDDGGLLDD----SNGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDE 317

  Fly   322 LPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGA 386
            .||:||:....:::..|.:|..||.:|..|::||.|....|:||||:|||.|:.||:.||.||..
Frog   318 FPGWRRRHWVVKMVTCVIVGLLFPAFSCCYLIAPKSTFGLFIRKPFIKFICHTASYLTFLFLLLL 382

  Fly   387 ASLRVVQITFELLAFPWMLTMLEDWRKHERGSLPGP----IELAIITYIMALIFEELKSLYSDGL 447
            ||..:                      ::..||.||    :|..|:.:::..|:.|:|.::..|.
Frog   383 ASQNI----------------------NKTESLQGPAPTIVEWMILPWVLGFIWGEIKQMWDGGF 425

  Fly   448 FEYIMDLWNIVDYISNMFYVTWILCRATAWVIVH--RDLWFRGIDPYFPREHWHPFDPMLLSEGA 510
            .:||.|.||::|::.|..|:..|..:..|:|..|  |:           |..|..|.|.|::|..
Frog   426 QDYIHDWWNLMDFVMNSLYLATISLKIVAYVKFHGQRN-----------RAEWEMFHPTLVAEAV 479

  Fly   511 FAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYY-AEL 574
            ||...:||.|:|:.:|:.|.||||||:|||||::||:||.|||.|||.||..|||||.:|| |:.
Frog   480 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEADA 544

  Fly   575 EKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWAL 639
            :.:.|..:.     .:.|..|      ||.||||.|||||:.|||::|...::.....||.|...
Frog   545 KSSGCKGIR-----CEKQNNA------FSTLFETLQSLFWSIFGLINLYVTNVDPKHEFTEFVGA 598

  Fly   640 LMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPN- 703
            .|||:|:||:::||||||||||:||||:|::.||.||||||::|||||||:|||:|.|||:.|:
Frog   599 TMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNIIPSP 663

  Fly   704 ------MKMLRKTLGRKRPSR-TKSFMRKSMERAQTL-----HDKVMKLLVRRYITAEQR-RRDD 755
                  :|.:||.:.:|:..| .:||.......|..|     :.:|||.||:||:.|..| .:.:
Frog   664 KSLWYLIKWIRKQICKKKMKRKPESFGAIGRRAADNLRRHNHYQEVMKNLVKRYVAAMIRDAKTE 728

  Fly   756 YGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVA----RTTKGKVMERRI---LK 813
            .|:||::..|::|||||.|||:|.:...|.:::.. .|.:.|:.    ...|.|:.|:|.   .|
Frog   729 EGLTEENFKELKQDISSFRFEVLGLLKGNKFNIQS-SKMNNGIGDIQETEEKSKIKEKRSRTQKK 792

  Fly   814 DFQIGFVENL---KQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASD----PIG 871
            :|.:..:..:   |..:..|:....:.:..|.:......:|        .|||:|.:|    .:.
Frog   793 NFSLFDITTMIHPKSAVIASDVHNSVSNGSALLASELVKEK--------QRKNSFVTDIKSFGLF 849

  Fly   872 SKRSSMQ-----RHSQRSLRRKIIEQANEGLQMNQT--QLIEFNP-----NLGDVTRATRVAYVK 924
            .|||...     ..:..|:..::..|.:..|..|.|  |:.|..|     |:..:|....::...
Frog   850 HKRSKSNFSDPISKTIYSVSEEVANQQDMELGDNTTDLQVKESEPASCELNVNKLTEQYALSPSS 914

  Fly   925 FMRKKMAADEVSLADDEGAPNGEGEK---KPLDASGSKKSIT 963
            ....::.:.:.|.:........|...   |.:|:.|.:.|.|
Frog   915 VNTSEIPSPQPSDSQHSSVALNEHSTDALKHMDSPGDENSTT 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	351/787 (45%)
		ANK	64..>168	CDD:238125	58/108 (54%)
		ANK repeat	69..98	CDD:293786	14/28 (50%)
		ANK repeat	99..135	CDD:293786	18/40 (45%)
		ANK repeat	137..168	CDD:293786	19/30 (63%)
		TRP_2	178..236	CDD:285535	39/57 (68%)
		BASP1	938..1158	CDD:283191	6/29 (21%)
trpc4	XP_002939629.3	trp	17..749	CDD:273311	351/791 (44%)
		ANK repeat	69..133	CDD:293786	34/70 (49%)
		ANK repeat	135..166	CDD:293786	19/30 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	784	1.000	Inparanoid score	I514
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm9358
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070