DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPP1 and Mpp2

DIOPT Version :9

Sequence 1:	NP_002427.1	Gene:	MPP1 / 4354	HGNCID:	7219	Length:	466	Species:	Homo sapiens
Sequence 2:	XP_008766350.1	Gene:	Mpp2 / 85275	RGDID:	620014	Length:	569	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	192/487 - (39%)
Similarity:	288/487 - (59%)	Gaps:	41/487 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     5 ASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEV--R 67
            |.:..:...:...|.:.:.:.||:        :|  ::|....|....|:||.......|.|  .
  Rat    99 AEQSSTAAELARILQEPHFQSLLE--------TH--DSVASKTYETPPPSPGLDPTFSNQPVPPD 153

Human    68 KVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQ 132
            .||::...|...|.:|:|.:: |.....:||||||||:.:||.|||||.|.|:||..| ......
  Rat   154 AVRMVGIRKTAGEHLGVTFRV-EGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRA 216

Human   133 LQKAMKETKGMISLKVIPN-QQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIIN 196
            ||:.::...|.:.||::|: |:..||. |:|::..|||||.:|:|||||||||:|..||::||:|
  Rat   217 LQELLRSASGSVILKILPSYQEPHLPR-QVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVN 280

Human   197 KDDSNWWQG-RVEGSSKESAGLIPSPELQEWRVASMAQS---APSEAPSCSPFGKKKKYKDKYLA 257
            :||:||||. .|||.   |||||||..|:|.|.|.:.:.   .|:....|.....|||.:..||.
  Rat   281 QDDANWWQACHVEGG---SAGLIPSQLLEEKRKAFVKRDLELTPTSGTLCGSLSGKKKKRMMYLT 342

Human   258 KHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPR 322
            ..::.||:.:::.||||.|:|.|:|||||||||.||||..:||.|:..:|:::...||||:|.|:
  Rat   343 TKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPK 407

Human   323 KSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKI 387
            .||.:|:.|.|:|..||..:|.|..:||.|.|:||::||:.:::..:....|:.:||:.||.:|:
  Rat   408 DSEREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKV 472

Human   388 VRTAELSPFIVFI-------------APTDQGTQTEALQQLQ-----KDSEAIRSQYAHYFDLSL 434
            :||||..|::|||             |..:.|..|:.|.:..     ::|..|:..|.|||||||
  Rat   473 LRTAEFVPYVVFIEAPDFETLRAMNRAALESGVSTKQLTEADLRRTVEESSRIQRGYGHYFDLSL 537

Human   435 VNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466
            ||:.::.|.::||.|.::..:.||||||||||
  Rat   538 VNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPP1	NP_002427.1	PDZ	71..149	CDD:366185	30/77 (39%)
		SH3_MPP1	162..223	CDD:213013	38/61 (62%)
		Interaction with PALS1. /evidence=ECO:0000269\|PubMed:17584769	268..466		90/215 (42%)
		Guanylate_kin	281..453	CDD:366206	75/189 (40%)
Mpp2	XP_008766350.1	L27	30..83	CDD:197794
		L27	85..136	CDD:280918	7/46 (15%)
		PDZ_signaling	155..233	CDD:238492	32/79 (41%)
		SH3_MPP2	246..304	CDD:212970	38/60 (63%)
		Guanylate_kin	366..556	CDD:279019	75/189 (40%)
		GuKc	376..557	CDD:214504	66/180 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D364535at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920