DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPP1 and Mpp3

DIOPT Version :9

Sequence 1:	NP_002427.1	Gene:	MPP1 / 4354	HGNCID:	7219	Length:	466	Species:	Homo sapiens
Sequence 2:	NP_446120.1	Gene:	Mpp3 / 114202	RGDID:	620015	Length:	585	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	154/504 - (30%)
Similarity:	252/504 - (50%)	Gaps:	74/504 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    26 LLQKRSRP--EAVSHPLNTVTEDMYTNGSPA-PGSPAQV----KGQEVRKVRLIQFEKVTEEPMG 83
            |||..|.|  .||....:||.:   .|..|. |..|..:    :.:.|:.|||::    .:||:|
  Rat    91 LLQLLSTPHLRAVLMVHDTVAQ---KNFDPVLPPLPDNIDEDFEEESVKIVRLVK----NKEPLG 148

Human    84 ITLKLNEKQ-SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLK 147
            .|::.:|.. :..||||:.||...|.|.:|||||:.|:||..|.:...|::.:.:.:::|.|:||
  Rat   149 ATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGITVLHKRPDEISQILAQSQGSITLK 213

Human   148 VIP--NQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGS 210
            :||  .::.|....::||||.|.|||::|..|||:||||.|....:::::::||..|||.:..|.
  Rat   214 IIPATQEEDRFKESKVFMRALFHYDPREDRAIPCQEAGLPFQQRQVLEVVSQDDPTWWQAKRVGD 278

Human   211 SKESAGLIPSPELQEWRVASMAQSA---------------PSEAPSCSPFGKKKKYKDKYLAKHS 260
            :...||||||.:.||.|::....:.               |.:..:|...|   .:|..|:|...
  Rat   279 TNLRAGLIPSKQFQERRLSYRRTTGTIPSPQNLRKPLYDQPCDKETCDCDG---YFKGHYVAGLR 340

Human   261 SIF--------------------DQLDVVSYEEVVRL---PAFKRKTLVLIGASGVGRSHIKNAL 302
            ..|                    :...:::||||.|.   |..:.:.:||||:.|.....:|..:
  Rat   341 RSFRLGCRERLTGSQEVKVPVGAESQVLLTYEEVARYQHQPGERSRLVVLIGSLGAHLHELKQRV 405

Human   303 LSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVH 367
            ::::|:.|...||:||||.:..|.:|.||||:|.:....:|..|:|||.|.::.|::||..|.:.
  Rat   406 VAEDPQHFGVAVPHTTRPRKSHEREGVEYHFVSKQAFEADIQHNKFLEHGEHKENLYGTSLEAIQ 470

Human   368 QIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPT---------------DQGTQTEALQQLQK 417
            .:..:||:.::|:||:.|:.:||.|..|:::|:.|.               |..|..:..||...
  Rat   471 TVMAKNKVCLVDVEPEALRHLRTPEFKPYVIFVKPAIQEKRKTPPVSPDSEDPATPLDEQQQEMA 535

Human   418 DSEA-IRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWV 465
            .|.| |...|.|..|..||...:.....:|:...:.......|||:|||
  Rat   536 ASAAFIDQHYGHLIDTVLVRQDLQSVCSQLRAVIESLSKDTYWVPISWV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPP1	NP_002427.1	PDZ	71..149	CDD:366185	28/78 (36%)
		SH3_MPP1	162..223	CDD:213013	29/60 (48%)
		Interaction with PALS1. /evidence=ECO:0000269\|PubMed:17584769	268..466		68/217 (31%)
		Guanylate_kin	281..453	CDD:366206	56/187 (30%)
Mpp3	NP_446120.1	L27	12..64	CDD:197794
		L27	71..121	CDD:197794	11/32 (34%)
		PDZ_signaling	135..215	CDD:238492	31/83 (37%)
		SH3_MPP3	230..291	CDD:212972	29/60 (48%)
		GuKc	395..571	CDD:214504	52/175 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..530		2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810