DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31038 and Trank1

DIOPT Version :9

Sequence 1:	NP_733326.1	Gene:	CG31038 / 43535	FlyBaseID:	FBgn0051038	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006512223.1	Gene:	Trank1 / 320429	MGIID:	1341834	Length:	3009	Species:	Mus musculus

Alignment Length:	921	Identity:	186/921 - (20%)
Similarity:	293/921 - (31%)	Gaps:	363/921 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATTAAGSAATTTNTMVVKRPGPPVPPRPKA-AAQLA--------------NGAGAPPIIQKKPT 50
            ||:|.||.........  .|.||  .||.:| .|:|:              .|||...::..|.|
Mouse     1 MASTTAGRRWPPRRRS--SRRGP--TPRSRAPGAKLSAPEAGPPRRGPLPRGGAGRDTLLGAKAT 61

  Fly    51 FVSQLSAVGRTLVYKSPTVNLPKKQAQTQTPTTAVPTP-PVKPLK--LRKAPDVPTAKPRDSMTS 112
            ..|  .|..|.:....|    |:.:..|.:...|:|.| |.:|.:  .|.||    |..|.:..|
Mouse    62 PSS--PAARRYVTALGP----PQPRGSTDSACAALPQPVPHEPREAAFRLAP----ASERGASVS 116

  Fly   113 VVTV-NRHNSISVIGS--TPQTTPRKDTRL---------SLGKVD-------------------F 146
            ...: .|...:..:..  ..:|.||:...|         :|||.:                   :
Mouse   117 PARIPRRRRRVPAMWDPRAARTPPRELAMLLCNKSNAFYNLGKWNEAFLAAKECLQWDPTYVKGY 181

  Fly   147 ERAG------LQP--ASQPLPRPRKIVQVPVATLDVEDIPVVAPSPSSNGLFRRSKTTLDGSQKD 203
            .|||      |||  |::......:::|.....|.|.|..|        |:|    ||:...
Mouse   182 YRAGYSLLHLLQPYEAARMFFEGLRLLQRSPDQLQVPDFLV--------GIF----TTMSSI--- 231

  Fly   204 SASSPHNGGG---------------FLSGRTVEI---------KNNLKNAA--------ERLFSE 236
            ..|.|  |||               |.:|.:.|:         |..|.:.:        :||.|.
Mouse   232 GMSDP--GGGDSIVLQSFLPCFDHIFTTGFSTEVWQYVIQKLAKKGLWHQSFLLLSAKKDRLPSN 294

  Fly   237 IIINQSQKQAATDTTI-ITKHEALKQESDVLA--------IQSSG-----NCMRINVNGGQTSTM 287
            |.:::...|:..:..: |..:|.|:|...::.        |::.|     ..||:.:...::...
Mouse   295 IHVSELSLQSLFEKYVFIGFYEKLEQVPKLVQWLVSIGANIETIGPNPLHALMRLCIQARESQLF 359

  Fly   288 KSSISVGNTPQKKQAFHEMLISELAAMRNKSCSLEQLPTAKSPPPTTSTPKSVASRRRYNSIDDA 352
            :..:.  ..|:.|:..:.        ..:..|::..:..|..|..|        |||:
Mouse   360 RWVMD--QKPEWKEHINH--------RDDAGCTVLHVAAAHFPGYT--------SRRQ------- 399

  Fly   353 DTEDVD------ADNVEDADG------DVDEEDTLTYAVNKSLKENIGKEGSSSR--KRCPSG-- 401
             ||||.      ||... .||      ||.:.:....|::| :..::.|..|||:  ...|:|
Mouse   400 -TEDVQMLLSFGADPTL-LDGHARTVVDVLKRNKNFRAIDK-INSHLEKLASSSKGLSEIPAGLV 461

  Fly   402 ------CSTDSSPYGTERSQRIRTSDWIEV---------GD----NGTAVTLTSCHIS------- 440
                  |:|....:..||.:      |.||         |.    ||   .:..|.:|
Mouse   462 CDVNRDCATTFIKFLLERQK------WPEVLLLLTRKVSGQPQLRNG---VIKDCDLSDLDICTV 517

  Fly   441 -----------------LEDSGMEDEERLDDMSSGVGDSWDS----------------VKEAESE 472
                             |.|||.        :..|:.||.|.                :....::
Mouse   518 IPHLSSWDQRKTQLLSRLIDSGA--------LPEGLQDSQDRPLLMCLRHEDFDLAFLLLTKGAD 574

  Fly   473 KRSRNGKRGNSACELPPLPKSL---------IGFNKL---------------------------- 500
            .||.:...|::     ||..:|         ||||.|
Mouse   575 PRSVSLVEGDT-----PLHAALHIFLDINADIGFNFLSHLLDLFLSNPTEFYYLNPNVQDSNGNT 634

  Fly   501 ---LCSDSGLLS------------DVEGN--NNSSDGSR---KPNDNLAV------------ETQ 533
               |....|:|.            |:..|  |.:..|.|   |.||.|.:            ..|
Mouse   635 LMHLLFQKGMLKRTKKLIDLLVKFDINFNLKNKAGKGVRHRIKKNDALLLAWNKALTESRRKNRQ 699

  Fly   534 DTKEHATDKSLPSSPNGNTSIPPMLVAKSEAKSPSLSAKGNPQAVEAG---STLDAQIATLRKEM 595
            |...|....|..|:| |:||     ..||:....||........:..|   |..|.|::  |:|.
Mouse   700 DPAAHLGRLSRSSAP-GHTS-----QLKSQTSFKSLPCGTADTTLSKGLTESLPDVQVS--RQEP 756

  Fly   596 NGLRQLDLSLLSQLWVLNESIQEFRALIEDQENEDEDDEVEVEVGNELDEEGNSRVSSSIESVRL 660
            ..:|...|.        :..:|:...||:           :||:|..|.|:...|     :|.::
Mouse   757 EAVRTRSLR--------DRLVQDITVLIQ-----------QVELGMPLPEDSPQR-----DSPKV 797

  Fly   661 EGGADGTSKHL 671
            ..|.:|....|
Mouse   798 AAGTEGKKDKL 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31038	NP_733326.1	PTZ00459	<447..>587	CDD:185638	43/227 (19%)
Trank1	XP_006512223.1	PHA03381	<22..>136	CDD:177618	28/123 (23%)
		TPR repeat	144..172	CDD:276809	4/27 (15%)
		TPR repeat	177..207	CDD:276809	7/29 (24%)
		PHA03095	317..>432	CDD:222980	25/141 (18%)
		ANK repeat	379..417	CDD:293786	13/54 (24%)
		ANKYR	498..681	CDD:223738	33/198 (17%)
		ANK repeat	552..579	CDD:293786	2/26 (8%)
		ANK repeat	582..629	CDD:293786	9/51 (18%)
		ANK repeat	631..666	CDD:293786	5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930