DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31038 and Trank1

DIOPT Version :9

Sequence 1:	NP_733326.1	Gene:	CG31038 / 43535	FlyBaseID:	FBgn0051038	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_038937542.1	Gene:	Trank1 / 316022	RGDID:	1563130	Length:	2999	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	157/791 - (19%)
Similarity:	269/791 - (34%)	Gaps:	278/791 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VSQLSAVGRTLVYKSPT--VNLPKKQAQ---TQTPTTAVPTPPVKPLKLRKAPD-VPTAKPRDSM 110
            :|:.||:|.|...||.|  .:||...|.   ::..|..:|...|    .|:.|: :.|...||.:
  Rat   697 LSRSSALGHTSQLKSQTSFKSLPCSTADRTLSKGVTEILPDVQV----TRQEPEAMRTRSLRDRL 757

  Fly   111 TSVVTVNRHNSISVIGSTPQTTPRKDT-RLSLGKVDFERAGLQPASQPLPRPRKIVQVPVATLDV 174
            ...:|| ....|.:..|.||..|::.: :::        ||::.....|.|.:
  Rat   758 VQDITV-LIQQIELDMSLPQDYPQQGSPKMA--------AGMEGKKDKLQRTQ------------ 801

  Fly   175 EDIPVVAPSPSSNGLFRRSKTTLDGSQKDSASSP------------HNGGGFLSGRTV-EIKNNL 226
                    |..|:|..|.:....:.....:.:.|            ...||.....|: ||:..|
  Rat   802 --------SMGSSGSSRDNPVASEAGDGHAQAGPGALQLAPVGNRLRVAGGNQDNWTMQEIQACL 858

  Fly   227 KNAAERLF-----SEIIINQSQKQAATDTTIITKHEALKQESDVLAIQSSGNCMRINVNGGQTST 286
            ::.....:     ||::...|.|       ::||  .:|::. :||||..|       ||..|..
  Rat   859 QDFDNMTWEIECTSEMLKKLSSK-------VMTK--VIKKKI-ILAIQQLG-------NGEWTQG 906

  Fly   287 MKSSI--SVGNTPQKKQAFHEML------ISELAAMRNKSCSLEQLPTAKSPPPTTSTPKSVASR 343
            ::..:  |.||.    |.|...|      :.|||...:..||             .::.|.:.:.
  Rat   907 LQKRLKHSKGNI----QLFEAKLDKGARMLWELAIDFSARCS-------------ENSEKIMGTE 954

  Fly   344 RRYNSIDDAD---TE-----DVDADNVEDAD-----------GDVDEEDTLTYAVNKSLKE-NIG 388
            |...|::.:.   ||     |:..|:.:.:|           |       |:..:.|.||. |.|
  Rat   955 RNTYSMEKSGRVYTEIIRIWDIVLDHCKLSDSIMAICSAYTRG-------LSCVLRKKLKGINKG 1012

  Fly   389 KEGSSSR--KRCPSGCSTDSSPYGTERSQRIRTSDWIEVGDNGTAVTL-----------TSCHIS 440
            :..::.:  ||.|. |..:.    ||..:.|..:| .|.....:||..           ||..::
  Rat  1013 QVSANMKIQKRIPR-CYVED----TEAEKSIEQAD-PEYFPPASAVETEYNIMKFHSFSTSMALN 1071

  Fly   441 LEDSGMEDEERLDDMSSGVGDSWDSVKEAESEKRSRNGKRGNSACELPPLPKSLI------GFNK 499
            :          |:||::.|            |...|.|:...:..:|.|.|...|      |..|
  Rat  1072 I----------LNDMTATV------------EYPFRVGELEYAVIDLNPKPLEPIILIGRSGTGK 1114

  Fly   500 LLC------------------SDSGLLS-------------DVEGNNNSSDGSRKPNDNLAVETQ 533
            ..|                  :.|.|||             ..||.....:.:.:...::.|||.
  Rat  1115 TTCCLYRLWKKFHVYWEKAEQAGSPLLSKQILPKRRLEVEPGKEGPGQEEEENEEEEGSIKVETV 1179

  Fly   534 DTKE-------------------HATDKSLPSSPNGNTSIPPMLVAKS-----EAKSPSLSAKGN 574
            |:.|                   .|.:..:|..|:....:..:.|.|:     |.:...:....:
  Rat  1180 DSTEEEQESEACAGGTVESAGDSQAAEGCVPDHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKS 1244

  Fly   575 PQAVEAGSTLDAQIATLR-------------KEMNGLRQLDLSLLSQLWVLNESIQEFRALI--E 624
            .:|......||..:..|:             |::  |..||.||....::.||.....|.::  .
  Rat  1245 TKATSHYKPLDPNVHKLQDLRDENFPLFVTSKQL--LLLLDASLPKPFFLRNEDGSLKRTIVGWS 1307

  Fly   625 DQEN------EDEDDEVEVEVGNELDEEGNSRVSSSIESVRLEGGADGTSKHLGTIPKVITT--- 680
            .||.      |:::||||.: ||..:||..:...:        |.:|         |:|..|
  Rat  1308 TQEEFSIPSWEEDEDEVEAD-GNYSEEEKTTETQT--------GDSD---------PRVYVTFEV 1354

  Fly   681 -----QPKVLR 686
                 .||:::
  Rat  1355 FTNEIWPKMIK 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31038	NP_733326.1	PTZ00459	<447..>587	CDD:185638	34/200 (17%)
Trank1	XP_038937542.1	PHA03381	<22..219	CDD:177618
		TPR repeat	144..172	CDD:276809
		TPR repeat	177..210	CDD:276809
		PHA03095	310..>451	CDD:222980
		ANK repeat	370..408	CDD:293786
		ANKYR	486..670	CDD:223738
		ANK repeat	541..568	CDD:293786
		ANK repeat	570..618	CDD:293786
		ANK repeat	620..655	CDD:293786
		UvrD	<1507..1760	CDD:223288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930