DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31038 and FAM89B

DIOPT Version :9

Sequence 1:	NP_733326.1	Gene:	CG31038 / 43535	FlyBaseID:	FBgn0051038	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001092255.1	Gene:	FAM89B / 23625	HGNCID:	16708	Length:	189	Species:	Homo sapiens

Alignment Length:	242	Identity:	71/242 - (29%)
Similarity:	95/242 - (39%)	Gaps:	93/242 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 GKRGNSACELPPLPKSLIGFNKLLCSDSGLLSDVEGNNNSSDGSRKPNDNLAVETQDTKEHATDK 542
            |..|.:...|||||:.|          ||||       |:|.||.:..:.  |.:|.::.|....
Human    11 GGAGCALAGLPPLPRGL----------SGLL-------NASGGSWRELER--VYSQRSRIHDELS 56

  Fly   543 SLPSSPNGNTSIPPMLVAKSEAKSPSLSAKGNPQAVEAGSTLDAQIATLRKEMNGLRQLDLSLLS 607
            ....:|:|     |...|.:....|   |.|..:.|    .||:.:|.|||||.||||||:|||.
Human    57 RAARAPDG-----PRHAAGAANAGP---AAGPRRPV----NLDSALAALRKEMVGLRQLDMSLLC 109

  Fly   608 QLWVLNESIQEFRALIED----QENEDEDDEVEVEVGNELDEEGNSRVSSSIESVRLEGGADGTS 668
            |||.|.||||:::.|.:|    |:                       :|||:.|
Human   110 QLWGLYESIQDYKHLCQDLSFCQD-----------------------LSSSLHS----------- 140

  Fly   669 KHLGTIPKVITTQPKVLRDSL----ATASKDQKPVPRMRSAPPPPPP 711
                              ||.    |..|.|::|..  .|.||.|||
Human   141 ------------------DSSYPPDAGLSDDEEPPD--ASLPPDPPP 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31038	NP_733326.1	PTZ00459	<447..>587	CDD:185638	29/108 (27%)
FAM89B	NP_001092255.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..83		7/36 (19%)
		LRR. /evidence=ECO:0000250\|UniProtKB:Q566R4	86..114		20/27 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..175		12/29 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141207
Domainoid	1	1.000	56	1.000	Domainoid score	I11009
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46949
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940