DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zip99C and SLC39A13

DIOPT Version :9

Sequence 1:	NP_001189313.1	Gene:	Zip99C / 43533	FlyBaseID:	FBgn0039714	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_024304530.1	Gene:	SLC39A13 / 91252	HGNCID:	20859	Length:	414	Species:	Homo sapiens

Alignment Length:	383	Identity:	159/383 - (41%)
Similarity:	205/383 - (53%)	Gaps:	100/383 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 WVFSLLGSVVIGLSGIFPLIIIPTEEKMAKEGYKDPADSKLLRVLLSFAVGGLLGDVFLHLLPEA 100
            |:.|||||:::||||:|||::||.|....   .:..|.:..|:.|||||:|||||:|||||||||
Human    68 WICSLLGSLMVGLSGVFPLLVIPLEMGTM---LRSEAGAWRLKQLLSFALGGLLGNVFLHLLPEA 129

  Fly   101 WE--------GDNQDPSSHPSLRSGLWVLSGILIFTIVEKIF-----SGYASADEENPQPKCVEI 152
            |.        |:.|.......|  ||||::|||.|..:||:|     .|.:.|..::|......:
Human   130 WAYTCSASPGGEGQSLQQQQQL--GLWVIAGILTFLALEKMFLDSKEEGTSQAPNKDPTAAAAAL 192

  Fly   153 --ANCLLRRHGGQLPEGETSESCGGACDIEDVGKVCFLREQEQKSKERKEQPKKVAGYLNLLANS 215
              .:||.:      |..|..           :|.|.              :..||:||||||||:
Human   193 NGGHCLAQ------PAAEPG-----------LGAVV--------------RSIKVSGYLNLLANT 226

  Fly   216 IDNFTHGLAVAGSFLVSFRHGILATFAILLHEIPHEVGDFAILLRSGFSRWDAARAQLLTAGAGL 280
            |||||||||||.|||||.:.|:|.|.|||||||||||||||||||:||.||.||:.||.||..||
Human   227 IDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDRWSAAKLQLSTALGGL 291

  Fly   281 LGALVAI----------------------------------------GGS---------GVTSAM 296
            |||..||                                        ||.         |.:.|.
Human   292 LGAGFAICTQSPKGVGTGVAGGCGGWHQQRGTSQRVWLPHCWSPGPGGGEHTQCLGYPVGCSPAA 356

  Fly   297 EARTSWIMPFTAGGFLHIALVTVLPDLLKEEERKESIKQLLALVFGIALMAVMTMLFE 354
            |...:|::|||:||||:||||.||||||:||:...|::|||.|..||.:|.:.::..:
Human   357 EETAAWVLPFTSGGFLYIALVNVLPDLLEEEDPWRSLQQLLLLCAGIVVMVLFSLFVD 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip99C	NP_001189313.1	Zip	34..350	CDD:280666	159/377 (42%)
SLC39A13	XP_024304530.1	Zip	65..408	CDD:308248	159/375 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62681
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3166
Isobase	1	0.950	-	0	Normalized mean entropy	S2015
OMA	1	1.010	-	-		QHG46433
OrthoDB	1	1.010	-	-		D548499at33208
OrthoFinder	1	1.000	-	-		FOG0001345
OrthoInspector	1	1.000	-	-		oto91400
orthoMCL	1	0.900	-	-		OOG6_108341
Panther	1	1.100	-	-	LDO	PTHR16950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1954
SonicParanoid	1	1.000	-	-		X5547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750