DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zip99C and Slc39a7

DIOPT Version :9

Sequence 1:	NP_001189313.1	Gene:	Zip99C / 43533	FlyBaseID:	FBgn0039714	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001071177.1	Gene:	Slc39a7 / 14977	MGIID:	95909	Length:	476	Species:	Mus musculus

Alignment Length:	359	Identity:	134/359 - (37%)
Similarity:	186/359 - (51%)	Gaps:	64/359 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TPWVFSLLGSVVIGLSGIFPLIIIPTEEKMAKEGYKDPADSKLLRVLLSFAVGGLLGDVFLHLLP 98
            |.|.::|..:|:|..:..|.|.:||.|.       ..|....||::|||||.||||||.||||:|
Mouse   141 TLWAYALGATVLISAAPFFVLFLIPVES-------NSPRHRSLLQILLSFASGGLLGDAFLHLIP 198

  Fly    99 EAWEGDNQDPSSH----------------PSLRSGLWVLSGILIFTIVEK----IFSGYASADEE 143
            .|.|     |.||                |.|..||||||||:.|.:|||    :..|:..:...
Mouse   199 HALE-----PHSHHAPEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGH 258

  Fly   144 NPQPKCVEIANCLLRRHGGQLPEGETSE-SCGGACDIEDVGKVCFLREQ--------------EQ 193
            ..:           ..||.....|:..| |.......|:..:|..||::              :.
Mouse   259 GDR-----------HAHGDSHTHGDRHECSSKEKPSTEEEKEVGGLRKRRGGNTGPRDGPVKPQS 312

  Fly   194 KSKERKEQPKKVAGYLNLLANSIDNFTHGLAVAGSFLVSFRHGILATFAILLHEIPHEVGDFAIL 258
            ..:|:.....:|:|||||.|:...|||.|||:..||......|||.|..:||||:||||||||||
Mouse   313 PEEEKAGSDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAIL 377

  Fly   259 LRSGFSRWDAARAQLLTAGAGLLG---ALVAIGGSGVTS--AMEARTSWIMPFTAGGFLHIALVT 318
            ::||.|:..|.|.||:||...|.|   ||:..||: |.|  |..|...|::|||||||:::|.|:
Mouse   378 VQSGCSKKQAMRLQLVTAIGALAGTACALLTEGGA-VDSDVAGGAGPGWVLPFTAGGFIYVATVS 441

  Fly   319 VLPDLLKEEERKESIKQLLALVFGIALMAVMTML 352
            |||:||:|....:|:.::|.|:.|:|:|.::..|
Mouse   442 VLPELLREASPLQSLLEVLGLLGGVAMMVLIAHL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip99C	NP_001189313.1	Zip	34..350	CDD:280666	133/355 (37%)
Slc39a7	NP_001071177.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..131
		Zip	140..453	CDD:280666	127/335 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..320		11/81 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D548499at33208
OrthoFinder	1	1.000	-	-		FOG0001345
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1954
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850