Protein Alignment MPO and CG42331

DIOPT Version :10

• Sequence 1: NP_000241.1
• Gene: MPO / 4353
• HGNCID: 7218
• Length: 745
• Species: Homo sapiens
• Sequence 2: NP_651282.2
• Gene: CG42331 / 42948
• FlyBaseID: FBgn0259233
• Length: 1615
• Species: Drosophila melanogaster
• Alignment Length: 795
• Identity: 247/795 - (31%)
• Similarity: 366/795 - (46%)
• Gaps: 145/795 - (18%)

Human    29 LLLALAGLLAIL----ATPQPSEGAAPAV-LGEVDTSLVLSSMEEAK--------------QLVD 74
            ||:||..||..|    ..|...|...|.: |.:.|....|....|||              .|:|
  Fly     6 LLVALLLLLVHLENASGKPPTKELPRPLIPLHDQDQEEELQPELEAKATFQSTRNGRSRRPTLMD 70

Human    75 KAYKERRESIKQ---------------RLRSGSA----SPMELLSYFKQPVAATRTAVRAADYLH 120
            .|.   ::|::|               .||:|..    .|..:||.|..|...:.....|| |..
  Fly    71 VAL---QQSVRQGLDAMTELYGRIQPEMLRNGQTLQDNHPAAMLSRFNAPTTDSERREMAA-YAT 131

Human   121 VALDLLERKLRSLWRRPFNVTDVLT------PAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGM 179
            :|       ....:|:.|...|.|.      ...|...:....|..:|.....|..::|||..|.
  Fly   132 IA-------AAKAFRKNFQHIDELARQSHTQRISLRRTALEGLCPPRDPPPCMPASERYRTHDGT 189

Human   180 CNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTP 244
            |||:|.|..||:...|.|:||.||.||..     |.....:|..::.:|.|| .:|....:...|
  Fly   190 CNNKRRPRWGAAQMPFNRFLPPEYGDGVD-----TVRSSADGSTLSSSRFVS-LLVHGAREGEAP 248

Human   245 DQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQ----QPPCFPLKIPPNDPRIKN 305
               .:||..||||:||||:..|.:|.:....:      .||..    .|.|||:|:|.:||.:..
  Fly   249 ---LTLMIAQWGQMLDHDMTSTAQPRSINGSI------PSCCGGKDFHPACFPIKVPLDDPWLAP 304

Human   306 -QADCIPFFRSCPA----CPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAV 365
             :..|:.|.||.||    |.   ::.|.|.|.:||::|||.:|.:....:.|.|...:  |||..
  Fly   305 LKVRCLEFLRSAPAQRRDCV---LSWREQTNQVTSYIDASPIYSNSAKSSDNARVFRH--GLLVY 364

Human   366 NQRFQDNGRALLPFDNLHDDPCLLTNRSA-RIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATE 429
                   ||.     :..:|.|   .|.| ...|..:||.||.|.|.|.:||.:.:.||||:|.|
  Fly   365 -------GRG-----DPAEDVC---QRGAIATKCIRSGDGRSGEQPGLLAMHHVWVGEHNRIAME 414

Human   430 LKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKY----LPT--YRSYNDSVDP 488
            |..|||.|..|::|||.|:|||||.|.||:|::||::||...::.:    :|:  |..|:..|:|
  Fly   415 LSELNPHWSDEKVYQETRRIVGAMFQHITFREFLPVILGREVVKLFDLELMPSGYYERYSSKVNP 479

Human   489 RIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMA 552
            .:||.| ..|||:||:|:|....|.|..:..:  |..|.|... |....:...|.:..:||||.:
  Fly   480 TVANAFAAAAFRFGHSLVQNSYTRCDRHHNVI--NNNVSLHEE-FQRGDIGSAGSLHRLLRGLAS 541

Human   553 TPAKLNRQNQIAVDEIRERLFEQV-MRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQ------ 610
            ..|.  ::::....|:...||:.. ...||||.|:|:||.||||:..|:|||..|||..
  Fly   542 QRAL--KRDEFITPELTNHLFQTPGFPFGLDLAAINIQRGRDHGIAPYSAWRVPCGLSPILSWDD 604

Human   611 ------PETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQF 669
                  ||:..::|...|::             ::||:::||::|.....|.|||..||||..||
  Fly   605 FANVVGPESAKRIGHAYRSV-------------HDIDLFVGGIAERPVVGGLVGPTFACIIAQQF 656

Human   670 RKLRDGDRFWWEN---EGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSY---PRDFV 728
            ...|.|||||:||   |..|:..|..:|.::||.:::|...|..|: :.:||:...:   .|...
  Fly   657 SNSRRGDRFWYENGGFESSFTPAQLHSLRRVSLAQVLCRTVGGGTL-QPHIFIPAEFEDNERQTC 720

Human   729 NCSTLPALNLASWRE 743
            ...:|..::|:.|.|
  Fly   721 GVGSLSPIDLSPWLE 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	150/442 (34%)
CG42331	NP_651282.2	An_peroxidase	183..707	CDD:460804	199/577 (34%)
		LHP1	731..>871	CDD:227520	2/5 (40%)