DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPO and cd

DIOPT Version :9

Sequence 1:	NP_000241.1	Gene:	MPO / 4353	HGNCID:	7218	Length:	745	Species:	Homo sapiens
Sequence 2:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	253/799 - (31%)
Similarity:	372/799 - (46%)	Gaps:	115/799 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGVPF----FSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILA--TPQPSEGAA-----PAVL 54
            ||:.|    |::| |:..:.....||..........:.|..:.||  .|.|.|.||     .|.|
  Fly    51 MGITFIAIVFTAL-CLALVFSDSLGGADGGPSFFFVVNGSDSELAPNRPLPDEPAAEWALQQAAL 114

Human    55 GEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSY--FKQPVAATRTAVRAAD 117
            |..|.:..:|:  ..|.|.|      ||.:::.|:....:......|  ......|.:.|.|...
  Fly   115 GHHDGAQAVSA--GIKALGD------REILEEGLQPNEVNTPSFRHYRSLSTNPEARKLARRGYV 171

Human   118 YLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDV-------GVTCPEQDKYRT 175
            .....:|:.:|         ||.|.  .|.:.|:     |...:.|       .:.|....:||.
  Fly   172 ENQATIDIAKR---------FNYTK--QPGRSNI-----GWGPKIVLPDPTVLRLECDFNARYRR 220

Human   176 ITGMCNNRRSP-TLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPT 239
            .||:|||::.| |.|||...:.|.:..:|.||.:     .|.|..:| .:..||.||.:|.|
  Fly   221 STGVCNNKQHPRTYGASMVPYRRMVSPDYADGIA-----APRVSHHG-RLPPARQVSLKIHR--- 276

Human   240 DQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCV-----QQPPCFPLKIPPN 299
            .....|...::|...:||.:|||:..|....::..  ..::|   ||     |.|.|:|:.|.|:
  Fly   277 SSYETDSNFTVMLAVFGQFMDHDITATSLTTSQEG--ESIDC---CVAATREQHPECYPVDILPD 336

Human   300 DPRIKN-QADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLL 363
            ||..|. ...|:.|.||.|| |......|.|:|..|:|:|||:|||:.|.....||:..|.
  Fly   337 DPYYKQYNISCMNFVRSAPA-PTGRFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFING---- 396

Human   364 AVNQRFQDNGRALLPFDNLHDDPCLLTNR--SARIP--CFLAGDTRSSEMPELTSMHTLLLREHN 424
            ::.....|:||.|||..:...|.|   ||  ..|:.  ||.:||.|::|...|||||.|..|.||
  Fly   397 SLRMFVTDDGRQLLPISSNPADGC---NRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHN 458

Human   425 RLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGP--TAMRKYLPTYR------S 481
            .||.:|:..||.|:.||||||||||:||.:..|||.::||::||.  :..:..||...      :
  Fly   459 YLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDT 523

Human   482 YNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDP 545
            |:..|||.|||.| ..|||:.|||: |.:|.:.......|   .:.|.::.|..:.:..|.|||.
  Fly   524 YDPEVDPSIANCFAAAAFRFAHTLL-PGLFNISRDNSTPE---AIELHKMLFNPFSLWAEHGIDH 584

Human   546 ILRGLMATPAKLNRQNQIAVD-----EIRERLFE-----QVMRIGLDLPALNMQRSRDHGLPGYN 600
            .|.....||.       :.||     |:.::|||     :|...||||.:||:||.||||:|.|.
  Fly   585 ALMTAANTPV-------MQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYP 642

Human   601 AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACII 665
            .:||.|.||..:|..::...:.|..| ..:.:.|.:|.::|::.|.:|||.......||||:|::
  Fly   643 VFRRHCRLPTVDTWEEMSQAIDNATL-DSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMV 706

Human   666 GTQFRKLRDGDRFWWENE---GVFSMQQRQALAQISLPRIICDNT-GITTVSKNNIFMSNSYPRD 726
            ..||.:|:.||..|:|.:   ..|:..|...:.:.||..|||.|: |||.|.::.:.........
  Fly   707 SDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNP 771

Human   727 FVNCSTLPA--LNLASWRE 743
            .|:|..|..  .|...|.|
  Fly   772 HVDCQDLEGFHFNFEPWSE 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	157/438 (36%)
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	203/570 (36%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	149/404 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820