Protein Alignment MPO and CG4009

DIOPT Version :10

• Sequence 1: NP_000241.1
• Gene: MPO / 4353
• HGNCID: 7218
• Length: 745
• Species: Homo sapiens
• Sequence 2: NP_650588.2
• Gene: CG4009 / 42054
• FlyBaseID: FBgn0038469
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 621
• Identity: 185/621 - (29%)
• Similarity: 279/621 - (44%)
• Gaps: 123/621 - (19%)

Human   173 YRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRF 237
            |||:.|.|||...|..|.:...:.|.||                      |..:.:|.:..::..
  Fly    95 YRTLDGSCNNLLYPEFGIAVSRYRRLLP----------------------PRQVEQAPNARLISL 137

Human   238 PT--DQLTPDQERSLMFMQWGQLLDHDL----------DFTPEPAARASFVTGVNCETSCVQQPP 290
            ..  :|...|:.|::..|||||.:.||:          |...||                 :.|.
  Fly   138 SLYGEQTRNDRFRTMAAMQWGQFVAHDISQLSTQGAPQDCCAEP-----------------RHPR 185

Human   291 CFPLKIPPNDP-RIKNQADCIPFFRSC----PACPGSNITIRNQINALTSFVDASMVYGSEEPLA 350
            |.|:.:|...| .......|:.|.||.    ..||........::...|:::|.|.:||:.....
  Fly   186 CLPINLPRGGPIAYHTGKTCLHFARSVSDADAICPKVEEPQPEKLTVATAYLDLSSIYGNNPSQN 250

Human   351 RNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSM 415
            |.:|....  |||..:   ..||:..||.....:..|     .|:..|::..|.|:...|.:..:
  Fly   251 RKVRLFKG--GLLKTS---YTNGQHWLPVSQNENGEC-----GAKSECYIVPDIRNRFSPTIALL 305

Human   416 HTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYL---- 476
            .|||:|||||||..|..:||....||::||||||..|..|.|||.|:|||.:|.|  ..||
  Fly   306 QTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLFVGRT--YTYLNGLI 368

Human   477 ----PT--YRSYNDSVDP-RIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPR----VPLSRV 530
                ||  ...|:::|:| ..|.....||||.||.| |..|.|      :.||.|    :.||..
  Fly   369 YPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHTQI-PGWFSL------VAPNRRSNRTMRLSDF 426

Human   531 FFASWRVVL---EGGIDPILRGLMATPAKLNRQNQIAVD-EIR----ERLFEQVMRIGLDLPALN 587
            ...:..:.|   ....|.:|||| ||  :|::::...:| ||:    .:.||:   .|.||.:::
  Fly   427 LDRTETIRLLDTSDNFDALLRGL-AT--QLHKRSDGNIDREIKHYFNRKEFEE---YGSDLKSID 485

Human   588 MQRSRDHGLPGYNAWRRFCGLPQP--------ETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWM 644
            :||:||.||..||..|.||||.:.        |..|:..::||.|         |.||:::::.:
  Fly   486 IQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKISLLRRL---------YATPDDVELGV 541

Human   645 GGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWW--ENEGVFSMQQRQALAQISLPRIICDNT 707
            ||..|........||.|.|:||.||...|.||||::  ||||.||..|...:.::||..:.|.|.
  Fly   542 GGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEIRKVSLSSLFCSNA 606

Human   708 GITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743
            ....:.:.|:|:..:.....:||:.:|.::|:.|::
  Fly   607 NYLHLIQPNVFVFPNSHNLLLNCNFIPQIDLSKWQD 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	144/448 (32%)
CG4009	NP_650588.2	An_peroxidase	95..617	CDD:460804	179/594 (30%)