Protein Alignment MPO and Irc

DIOPT Version :10

• Sequence 1: NP_000241.1
• Gene: MPO / 4353
• HGNCID: 7218
• Length: 745
• Species: Homo sapiens
• Sequence 2: NP_650584.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Alignment Length: 799
• Identity: 194/799 - (24%)
• Similarity: 302/799 - (37%)
• Gaps: 210/799 - (26%)

Human    29 LLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRL----- 88
            ||..:.|...:......|.....|.|..:..|..|..:|.|...|:     |::.::..|
  Fly     9 LLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVN-----RQKRLEDNLLGSDI 68

Human    89 --RSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNV 151
              ::||.|..:||...  |..|::...:      :||.:|:..|
  Fly    69 TVKNGSLSHAQLLDTL--PSLASKKDNK------LALKILKSSL--------------------- 104

Human   152 LSKSSGCAYQDV-GVTC---------PEQDKYRTITGMCNNRRSPTLGASNR----AFVRWL-PA 201
            |..:|.|...:: |..|         ||....||   .|.|...     .||    ||.|.| .:
  Fly   105 LVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRT---ECENSLK-----GNREGHYAFRRLLGSS 161

Human   202 EYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFP-----TDQLTPDQERSLMFMQWGQLLDH 261
            .|.:||   |...|...|.. .|..|.::|.|:.. |     :.|.|.:...:|...||.|.::|
  Fly   162 HYRNGF---YQMFPNSGRRE-TVPAAWSISKELYE-PDHIQISKQQTFESNSNLALPQWAQFVEH 221

Human   262 DLDFTPEPAARASFVTGVNCETSCVQQ---------PPCFPLKIPPNDPRIKNQADCIPFFRSCP 317
            ||.   :|.:: |...|...|.....|         |.|.|:...|...  .:...|:.:.||..
  Fly   222 DLS---KPVSQ-SMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGGK--YDVPSCLNYVRSAL 280

Human   318 ACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQ-DNGRALLPFDN 381
            |....|.....|:|..|..:|.|.:||......|.||.:..  |||....|.: ||  ||||...
  Fly   281 AVADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEG--GLLRSTPRGEFDN--ALLPIAT 341

Human   382 LHDDPCLLTNRSARI---PCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLY 443
            ..:.|.....  |.|   .||.|||:|.:..|....::|:.:|.||::|.|||..||||..|:|:
  Fly   342 DTEGPSFCAR--ATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLF 404

Human   444 QEARKIVGAMVQIITYRDYLPLVLG---PTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTL 504
            |.|:.:...:.:.:...::||.|||   .:.:|:..|     |.:::  ::|.| ..|.|:..::
  Fly   405 QAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQP-----NRALE--VSNEFAVAAIRFYFSM 462

Human   505 IQPFMFRL--DNRYQPMEPN-------PRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQ 560
            :...:..|  ||.....|.|       ..:|...:|.....:...        .|..|..|||
  Fly   463 LPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKP--------KLQYTSQKLN-- 517

Human   561 NQIAVDEIRERLFEQ-VMRIG-----------------LDLPALNMQRSRDHGLPGYNAWRRFCG 607
                  .|.|.|..| .|::.                 .|:.|.::||.|||||..|..:...|.
  Fly   518 ------NILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCV 576

Human   608 LPQP-------------ETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSE-PLKRKGRVG 658
            |.:|             :.:.:|.|:             |.:..::|:.:||:|| |:  .|.:|
  Fly   577 LSRPVESWKDFEHFIPSDVLDKLKTI-------------YASWADVDLIVGGISENPV--HGSIG 626

Human   659 PLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALA------------QISLPRIICDNTGITT 711
            |..:|||..||               |..::|.|..|            ..:..:::|.|:|::.
  Fly   627 PTFSCIISEQF---------------VHVLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSA 676

Human   712 VSKNNIFMSNSYPRDFVNC 730
            |.: |||...|.....|:|
  Fly   677 VPQ-NIFQLPSARNQMVSC 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	119/472 (25%)
Irc	NP_650584.1	An_peroxidase	151..682	CDD:460804	152/601 (25%)