Protein Alignment MPO and Pxn

DIOPT Version :10

• Sequence 1: NP_000241.1
• Gene: MPO / 4353
• HGNCID: 7218
• Length: 745
• Species: Homo sapiens
• Sequence 2: NP_523891.2
• Gene: Pxn / 38326
• FlyBaseID: FBgn0011828
• Length: 1527
• Species: Drosophila melanogaster
• Alignment Length: 728
• Identity: 280/728 - (38%)
• Similarity: 413/728 - (56%)
• Gaps: 45/728 - (6%)

Human    46 SEGAAPAVLGEVDTS----LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPM--ELLSYFKQ 104
            |..|...:...||.:    .|..:..||.:.:|.|.....:.:... ||..|.|.  |||..|:.
  Fly   637 SASALVTIRNNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSN-RSDKAPPNYGELLRVFRF 700

Human   105 PVAATRTAVRAADYLHVALDLLERKLR-----SLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVG 164
            |....|...|||:.....|..:.:.::     ::....:...|:|:...|:::::.|||......
  Fly   701 PTGEARQLARAAEIYERTLVNIRKHVQEGDNLTMKSEEYEFRDLLSREHLHLVAELSGCMEHREM 765

Human   165 VTCPE---QDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVAL 226
            ..|.:   ..:||:|.|.|||.:.||.|||..||.|..|..||:|||:|.|||.|:..:|.....
  Fly   766 PNCTDMCFHSRYRSIDGTCNNLQHPTWGASLTAFRRLAPPIYENGFSMPVGWTKGMLYSGHAKPS 830

Human   227 ARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPC 291
            ||.||..:|  .|.::|||...:.|.|||||.||||||.. .|:..:....|::|:.||...|||
  Fly   831 ARLVSTSLV--ATKEITPDARITHMVMQWGQFLDHDLDHA-IPSVSSESWDGIDCKKSCEMAPPC 892

Human   292 FPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITI--------RNQINALTSFVDASMVYGSEEP 348
            :|:::||||||::|:. ||...||...| ||.:|.        |.|||.|||::|||.|||....
  Fly   893 YPIEVPPNDPRVRNRR-CIDVVRSSAIC-GSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTA 955

Human   349 LARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDD-PCLLTNRSARIPCFLAGDTRSSEMPEL 412
            .|:.|||:::|.|||.|...| ...:.:|||....|. .|........:.||::||.|.:|...|
  Fly   956 FAQELRNLTSQEGLLRVGVHF-PRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGL 1019

Human   413 TSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLP 477
            .:|||:.:|||||:|::||.:|..|||:.|||||||||||.:|.||::.:|||::|.:.| :.:.
  Fly  1020 LAMHTIWMREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGM-EMMG 1083

Human   478 TYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEG 541
            .|:.||..::|.|||.| |.|.|:|||:|.|.:.||:..:||: |...:.|.:.|||.||:..||
  Fly  1084 EYQGYNPQLNPSIANEFATAALRFGHTIINPILHRLNETFQPI-PQGHLLLHKAFFAPWRLAYEG 1147

Human   542 GIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFC 606
            |:||::||.:|.||||...:|....|:.|:||:....:.|||.|:|:||.||||:||||.:|:.|
  Fly  1148 GVDPLMRGFLAVPAKLKTPDQNLNTELTEKLFQTAHAVALDLAAINIQRGRDHGMPGYNVYRKLC 1212

Human   607 GLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRK 671
            .|...:....|...:.:.::.:|:.|.||.|:|:|:|:||:.|.....|:||||..|::..|||:
  Fly  1213 NLTVAQDFEDLAGEISSAEIRQKMKELYGHPDNVDVWLGGILEDQVEGGKVGPLFQCLLVEQFRR 1277

Human   672 LRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKN------NIFMSNSYPRDFVNC 730
            ||||||.::||.||||.:|...:.|.:..|::||      |..|      |:|:...:...:..|
  Fly  1278 LRDGDRLYYENPGVFSPEQLTQIKQANFGRVLCD------VGDNFDQVTENVFILAKHQGGYKKC 1336

Human   731 STLPALNLASWRE 743
            ..:..:||..|:|
  Fly  1337 EDIIGINLYLWQE 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	177/427 (41%)
Pxn	NP_523891.2	leucine-rich repeat	54..77	CDD:275380
		LRR	<55..>184	CDD:443914
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..173	CDD:275380
		Ig_3	235..311	CDD:464046
		Ig	366..450	CDD:472250
		Ig strand B	384..388	CDD:409544
		Ig strand C	397..401	CDD:409544
		Ig strand E	420..424	CDD:409544
		Ig strand F	434..439	CDD:409544
		Ig strand G	447..450	CDD:409544
		Ig_3	458..533	CDD:464046
		Ig	553..644	CDD:472250	2/6 (33%)
		Ig strand B	570..574	CDD:409353
		Ig strand C	584..588	CDD:409353
		Ig strand E	610..614	CDD:409353
		Ig strand F	624..629	CDD:409353
		Ig strand G	638..641	CDD:409353	0/2 (0%)
		peroxidasin_like	898..1338	CDD:188658	189/450 (42%)
		VWC	1465..1523	CDD:278520