Protein Alignment MPO and CG10211

DIOPT Version :10

• Sequence 1: NP_000241.1
• Gene: MPO / 4353
• HGNCID: 7218
• Length: 745
• Species: Homo sapiens
• Sequence 2: NP_609883.1
• Gene: CG10211 / 35106
• FlyBaseID: FBgn0032685
• Length: 1394
• Species: Drosophila melanogaster
• Alignment Length: 755
• Identity: 254/755 - (33%)
• Similarity: 379/755 - (50%)
• Gaps: 106/755 - (14%)

Human    47 EGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRE------SIKQRLRSGSASPMELLSYFKQP 105
            |.|....:.|:...|:.:::|.|||.:::..:...|      .|..|...|:|:     |:.|..
  Fly   577 EPATKEAIAELSPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSPDGTAA-----SFSKAN 636

Human   106 VAATRTAVRA------ADYLHVALDLLERKLRSLW---RRPFNVTDVLTPAQLNVLSKSSGCAYQ 161
            :||...|..:      ::.:...|:.:.|:.|.::   :..||..::....|...:|...|.|.:
  Fly   637 LAALNLANSSLIFELTSNEIVKTLNHITRRKRQIFNPNQNAFNRNELTDTLQTVDISGLLGGAQK 701

Human   162 DVGVTCPEQDK-------YRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKR 219
            .:. ||||..:       :||::|.|||.|:|..|.|...|.|.|||:||||.|.|.  ..||..
  Fly   702 QLD-TCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPR--LTGVTG 763

Human   220 NGFP------VALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTP--------EPA 270
            ...|      ..:...:||...|:           |||.||:.|.:||||..||        .|:
  Fly   764 TALPNPRTISTTIHPDISNLHTRY-----------SLMVMQFAQFVDHDLTLTPIHKGFHESIPS 817

Human   271 ARASFVTGVNCETSCVQQPPCFPLKIPPND---PRI---KNQADCIPFFRSCPACPGSNITIRNQ 329
            .|.       |.:.....|.|.|..:|..|   |.:   ..:..|.|..||.|.  ..::..|:|
  Fly   818 CRP-------CNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSLPG--QQSLGPRDQ 873

Human   330 INALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSA 394
            ||..|.|:|.|||||....|:..||..|.::....|      .|:.|||. ..|.: |    :|.
  Fly   874 INQNTHFLDGSMVYGETTCLSNKLRGFSGRMNSTQV------RGKELLPL-GPHPE-C----KSR 926

Human   395 RIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITY 459
            ...|||.||.|:||.|.||::||..||||||:...|:.:||.|:||:|:..|||||.|.||.|.:
  Fly   927 NGLCFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVF 991

Human   460 RDYLPLVLGPTAMRKY----LPT--YRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQ 517
            .::||.:|...|:..|    ||.  |:.||.|..|.:.|.| ..|||.||:|::|.:.||..::|
  Fly   992 NEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSVQHQ 1056

Human   518 PMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFE--QVMRIG 580
            |:|| |.: |...||....::..|.||.|||||:|||  :...:|....|:...|||  ::...|
  Fly  1057 PVEP-PLL-LRDGFFRMDALLQPGIIDEILRGLVATP--METLDQFITGEVTNHLFEDRKIPFSG 1117

Human   581 LDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMG 645
            :||.|||:||:||||:|.||.:|..|.|.:......|...:.. ::..:..:.|.:.::||::.|
  Fly  1118 IDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPT-EVINRFQKIYASVDDIDLFPG 1181

Human   646 GVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN---EGVFSMQQRQALAQISLPRIICDNT 707
            .::|...:.|.|||.||||||.|||:||..||||:||   |..|:..|...:.:::|.:|:|:|.
  Fly  1182 AMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVCENL 1246

Human   708 GITTVSKNNIFMSNSYPRDFVN----CSTLPALNLASWRE 743
            .||...:...|   ..|.:|:|    |:::|.::|.:|||
  Fly  1247 EITGDMQRAAF---DLPSNFLNPRVPCASMPQIDLNAWRE 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	163/423 (39%)
CG10211	NP_609883.1	An_peroxidase	69..537	CDD:460804
		An_peroxidase	719..1257	CDD:460804	213/576 (37%)