Protein Alignment MPO and Duox

DIOPT Version :10

• Sequence 1: NP_000241.1
• Gene: MPO / 4353
• HGNCID: 7218
• Length: 745
• Species: Homo sapiens
• Sequence 2: NP_608715.2
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Alignment Length: 593
• Identity: 164/593 - (27%)
• Similarity: 268/593 - (45%)
• Gaps: 110/593 - (18%)

Human   169 EQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDG-FSLPYGWTPGVKRNGFPVALARAVSN 232
            |:.:|   .|..||...|..|:.:...||..|..|.|| :::.....|..:|          :|.
  Fly    68 EKQRY---DGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGANRPSTRR----------LSR 119

Human   233 EIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIP 297
            ..:| ..|.|.....|:.:...:|||:.:::....|        :|...|...::...|..:
  Fly   120 LFMR-GKDGLGSKFNRTALLAFFGQLVANEIVMASE--------SGCPIEMHRIEIEKCDEM--- 172

Human   298 PNDPRIKNQADC-----IPFFRSC--------PACPGSNITIRNQINALTSFVDASMVYGSEEPL 349
                   ...:|     |||.|:.        |..|      |.|||.:|:::|.|.:|.:.|..
  Fly   173 -------YDRECRGDKYIPFHRAAYDRDTGQSPNAP------REQINQMTAWIDGSFIYSTSEAW 224

Human   350 ARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIP----------------- 397
            ...:|:..|  |.|..    :.:|:  ||..|           :.|:|
  Fly   225 LNAMRSFHN--GTLLT----EKDGK--LPVRN-----------TMRVPLFNNPVPSVMKMLSPER 270

Human   398 CFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDY 462
            .||.||.|:::.|.:.|...|.||.||.||..:|.::|.|..|.:||.||..|.|.:|.:...:|
  Fly   271 LFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEY 335

Human   463 LPLVLGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDN----RYQPMEPN 522
            ||..||.:     ||.|..|...:.|.|.::| ..|||:|||:|.|.::|.|.    :..|| ..
  Fly   336 LPAFLGTS-----LPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFKETPM-GY 394

Human   523 PRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALN 587
            |.|.|...::.|.....:..::.:|.||.:..::  |::.:...::|::||..:.....||.|||
  Fly   395 PAVRLCSTWWDSSGFFADTSVEEVLMGLASQISE--REDPVLCSDVRDKLFGPMEFTRRDLGALN 457

Human   588 MQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVL--RNLKLARKLMEQYGTP-NNIDIWMGGVSE 649
            :.|.||:|||.||..|...||.:.:|...:...|  ...:|...|.|.|... :::|:::||:
  Fly   458 IMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYVGGM-- 520

Human   650 PLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENE--GVFSMQQRQALAQISLPRIICDNTGITTV 712
             |:..|:.|.....:|..||::|||.||||:|||  |:|:.::...|.:|:|..||.::|.:...
  Fly   521 -LESYGQPGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTDVKEE 584

Human   713 S-KNNIFM 719
            . :.::||
  Fly   585 EIQKDVFM 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	132/440 (30%)
Duox	NP_608715.2	dual_peroxidase_like	72..625	CDD:188652	163/589 (28%)
		PTZ00184	807..965	CDD:185504
		EFh	860..921	CDD:238008
		PLN02844	<1081..>1393	CDD:215453
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783