DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt1 and ino80db

DIOPT Version :9

Sequence 1:	NP_001287595.1	Gene:	dgt1 / 43529	FlyBaseID:	FBgn0039710	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_009300512.1	Gene:	ino80db / 563304	ZFINID:	ZDB-GENE-070112-2072	Length:	847	Species:	Danio rerio

Alignment Length:	726	Identity:	144/726 - (19%)
Similarity:	245/726 - (33%)	Gaps:	252/726 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EQIH-SELVKIKYCANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKY 92
            :.|| ||:.....|:.....|...|:.||.:||||:|.|..:.||||.:|.. |.::|.|.:.|.
Zfish     5 KHIHYSEVDHKPLCSYSPKLCKQRRLNGYAFCIRHVLEDRTAPFRQCEYVAKYNSQRCTNPIPKA 69

  Fly    93 DNKKELILTTLCFEHNRQTQLQKTHMNVGRIRSRVETNETLLHSLSSHINVEDIKPEVKKIERDD 157
            ..:|      .|..|     ||.  |.|...:.|.:..:| :.||:.:|.|..:      ..:..
Zfish    70 HERK------YCNSH-----LQV--MGVLPKKERKKKQDT-IESLALNITVPSL------ALKTH 114

  Fly   158 DEIDVVSPHVTPFVT-------------------------------------QDHRNSIGHVVES 185
            :.::::.|...|.:.                                     |||.....|:..|
Zfish   115 NGLEILPPSPPPALVCLLPSDPFAFYKEEKMFKSSGAFLKKPQETLNHKQKQQDHSVDANHLRTS 179

  Fly   186 SRKRR------------RILDYASDSSSNDADPPCLRN-----TAQDI-EFYESDHESIDSEDDD 232
            |....            |......:.||..|..|.:|:     |:..: :.::...:|.|::...
Zfish   180 SLPSTLSHSCLPPLLTGRATQTPINPSSPRAATPTVRSGSLFKTSSSLQDTHQGSKDSTDNKIKL 244

  Fly   233 PLKHAGVFTR---------AEAVKIAETKLIKLQGLYREQ----ISYLQNVLRQRRRKYLHDIR- 283
            .|.||  |.:         |......:::|||...:..:|    :..|..::.|.:.:: .|:.
Zfish   245 DLNHA--FDKKVVPAASGMAPCCDDTQSRLIKKCTVAMQQQAPCLKKLHRLMDQHKGRF-QDLNS 306

  Fly   284 -------------RERE-------LYCSIHDQLKDTPHERKLYEQLKALNSYHRRQGVEAVLYKK 328
                         .|.|       .|.....|.|.:...|...|:|....||.|::.:.....::
Zfish   307 HLACVPGLDWSEDSEEEDGDWKLVSYQCQRLQEKRSEESRSRAERLAGFCSYLRQKHMHLCREQR 371

  Fly   329 --LKEKRARDALYAA--------------------KSSSNPK-------------CVFTEGGVKC 358
              .:|:|::.||..|                    :.:|.|.             |.....|..|
Zfish   372 GFRRERRSQHALRKALVQAAREEPHQTAQLIQEQHQVTSAPSSTAVSLAGDDSGLCQAVVKGENC 436

  Fly   359 GERTLPCCKHCRKHILEDKRQVLFRACGVE-RSGVVCQEPVASILEDSS-CVLHLTVAPAKR--- 418
            ....||..:||.:|||:::.|.||.:|... ..|..|..||..|...:. |..|     ||:
Zfish   437 RNSALPFTRHCFQHILQNRSQQLFSSCTARFADGAQCSIPVFDITHQTPLCDEH-----AKKMDN 496

  Fly   419 --------------QYIQKFYEV-PSTPPVESIFAAGRGLDNFVGEDPRNEPQ-------PEGDD 461
                          |.||:...: .:.||..|.....:|     ....:..||       |:|:
Zfish   497 FLRGDISRRTYHHHQQIQRHRPLKKAKPPALSKKHKKKG-----KRGTQRRPQKPIPPALPQGN- 555

  Fly   462 LLDFANGIFDFDLDGVDDLANSLDDDYSMFLDMDSDLGLAIEDDGVESDPV--DLGLEEEGDGGS 524
                                          |.:.|.|.|..:..|:.| |:  ||..:|..|..:
Zfish   556 ------------------------------LALPSILCLPSQPSGIRS-PLTPDLSADEFPDDIT 589

  Fly   525 NDSVGPAESQAQDNLIAD---NFELEE-------PSVQDNNELNFDIDESESN--------VNEV 571
            ||             |:|   :.||.:       |.:.|:.: :||:.|.:::        ..|:
Zfish   590 ND-------------ISDIPHDLELNQEDFSDVLPRLPDDLQ-DFDLFEGKNSELLPTSEEAEEL 640

  Fly   572 LRLLEGIEHMP 582
            :|:|:.:...|
Zfish   641 VRVLQAMGSYP 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	22/65 (34%)
dgt1	NP_001287595.1	zf-C3Hc3H	349..411	CDD:290602	20/63 (32%)
ino80db	XP_009300512.1	zf-C3Hc3H	18..79	CDD:290602	23/71 (32%)
ino80db	XP_009300512.1	zf-C3Hc3H	432..491	CDD:290602	20/63 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11822
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5078
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.060