Protein Alignment dgt1 and KANSL2

DIOPT Version :9

• Sequence 1: NP_001287595.1
• Gene: dgt1 / 43529
• FlyBaseID: FBgn0039710
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_060292.3
• Gene: KANSL2 / 54934
• HGNCID: 26024
• Length: 492
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 180/546 - (32%)
• Similarity: 263/546 - (48%)
• Gaps: 118/546 - (21%)

  Fly    42 CANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKYDNKKELILTTLCF 105
            ||.....||..|:||.|:||:|||.|..:.|:|||::.: ||::|.||..|.:.|..:   :.|.
Human    28 CAFTHRPCSHPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPNAAPKPEKKDGV---SFCA 89

  Fly   106 EHNRQ------TQLQKTHMNVGRIRSRVETNETLLHSLSSHINVEDIKPEVKKIERDDDEIDVVS 164
            ||.|:      .|::||  |.|.:      .||||..|||:...|
Human    90 EHVRRNALALHAQMKKT--NPGPV------GETLLCQLSSYAKTE-------------------- 126

  Fly   165 PHVTPFVTQDHRNSIG-HVVESSR-KRRRILDYASDS-SSNDADPPCLRNTAQDIEFYESDHESI 226
                          :| ...|||| :..||||  .|| |..:.:|..:..|.:...  :|:.:||
Human   127 --------------LGSQTPESSRSEASRILD--EDSWSDGEQEPITVDQTWRGDP--DSEADSI 173

  Fly   227 DSEDDDPLKHAGVFTRAEAVKIAETKLIKLQGLYREQISYLQNVLRQRRRKYLHDIRRERELYCS 291
            ||:.:||||||||:|..|...|...|||:||.||.:|...||::|::::|:|||:.:.|.|   :
Human   174 DSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHE---A 235

  Fly   292 IHDQLKDTPH-----ERKLYEQLKALNSYHRRQGVEAVLYKKLKEKR--ARD--ALYAAKSSSNP 347
            :...|...|.     ||:..::||.|..|.:|.||||:|:::|||:|  |.|  |..|..:.|:.
Human   236 LGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQ 300

  Fly   348 KCVFTEGGVKCGERTLPCCKHCRKHILEDKRQVLFRAC-GVERSGVVCQEPV-ASILEDSSCVLH 410
            :|:.....|:|..::||..:||..||.:|..||||:.| |.|.  |.|.:|| .|:.||..|.||
Human   301 RCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEE--VPCNKPVPVSLSEDPCCPLH 363

  Fly   411 LTVAPAKRQYIQKFYEVPSTP------PVESIFAAGRGLDNFVGEDPRNEPQPEGDDLLDFANGI 469
            ..:.|    .:.|..:|.|.|      |::...:|.             |.||.....|:|::
Human   364 FQLPP----QMYKPEQVLSVPDDLEAGPMDLYLSAA-------------ELQPTESLPLEFSD-- 409

  Fly   470 FDFDLDGVDDLANSLDDDYSMFLDMDSDLGLAIEDDGVE---SDPVD-LG-LEEEGDG----GSN 525
               |||.|.|   .:....|..|   .|..|.:||..|:   .|||| || ::..|||    ||.
Human   410 ---DLDVVGD---GMQCPPSPLL---FDPSLTLEDHLVKEIAEDPVDILGQMQMAGDGCRSQGSR 465

  Fly   526 DSVGPAESQAQDNLIADNFELEEPSV 551
            :|...:...:|..|...|.:.|..|:
Human   466 NSEKASAPLSQSGLATANGKPEPTSI 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	26/65 (40%)
		zf-C3Hc3H	349..411	CDD:290602	26/63 (41%)
KANSL2	NP_060292.3	zf-C3Hc3H	28..91	CDD:372789	26/65 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..182		22/93 (24%)
		zf-C3Hc3H	307..364	CDD:372789	25/58 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..492		11/37 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157110
Domainoid	1	1.000	98	1.000	Domainoid score	I7225
eggNOG	1	0.900	-	-		E1_2CC1T
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32367
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3947
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	1	1.000	-	-		FOG0009923
OrthoInspector	1	1.000	-	-		oto89665
orthoMCL	1	0.900	-	-		OOG6_108516
Panther	1	1.100	-	-	LDO	PTHR13453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5324
SonicParanoid	1	1.000	-	-		X7615
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790