DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt1 and kansl2

DIOPT Version :9

Sequence 1:	NP_001287595.1	Gene:	dgt1 / 43529	FlyBaseID:	FBgn0039710	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_005162220.1	Gene:	kansl2 / 449817	ZFINID:	ZDB-GENE-041010-67	Length:	506	Species:	Danio rerio

Alignment Length:	559	Identity:	169/559 - (30%)
Similarity:	259/559 - (46%)	Gaps:	125/559 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKYDNKKELILTTLCF 105
            |:.....||..|:||.|:||:|:|.|..:.:||||::.: ||::|.||..|.:.|:.:   :.|.
Zfish    28 CSYTQRPCSQPRLEGLEFCIKHVLEDKNAPYRQCSYMSNKNGKRCPNAAPKPEKKESV---SFCA 89

  Fly   106 EHNRQTQL-QKTHMNVGRIRSRVETNETLLHSLSSHINVEDIKPEVKKIERDDDEIDVVSPHVTP 169
            ||.|:..| |:..|.  :..:...:.|.||..||.:     .:||..
Zfish    90 EHARRNALVQQAQMR--KASASGPSPEVLLSQLSGY-----SRPEPG------------------ 129

  Fly   170 FVTQDHRNSIGHVVESSRKRRRILDYASDSSSNDADPPCLRNTAQDIEFYESDHESIDSEDDDPL 234
                      .|..|...:..||||..| .|..:.||..|..|.:...  :|:.||:||:.:|||
Zfish   130 ----------AHSQEGHSEASRILDDES-WSEEEQDPVVLDQTWRGDP--DSEAESLDSDHEDPL 181

  Fly   235 KHAGVFTRAEAVKIAETKLIKLQGLYREQISYLQNVLRQRRRKYLHDIRRERELYCSIHDQLKDT 299
            |||||:|..|...|...|||:||.||.:|...||::|::::|:|||..:.|.|   :|...|...
Zfish   182 KHAGVYTAEEVALITREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHSRKIEHE---TIGSSLLTG 243

  Fly   300 PH-----ERKLYEQLKALNSYHRRQGVEAVLYKKLKEKRARDALYAAKSSSNP--------KCVF 351
            |.     ||:..::||||..|.||.||||:|:::|:|:|      .|.:...|        :|:.
Zfish   244 PEGLSMKERENLKKLKALRRYRRRYGVEALLHRQLRERR------QAITEGGPTQAMRLGQRCIS 302

  Fly   352 TEGGVKCGERTLPCCKHCRKHILEDKRQVLFRAC-GVERSGVVCQEPV-ASILEDSSCVLHLTVA 414
            ...|.:|..:.||..:||..||.:|..||||:.| |::  .|.|..|| ....|:..|.|||::.
Zfish   303 FVEGTRCSNQCLPMTRHCVSHIYQDSSQVLFKLCPGLK--DVPCDRPVHMGQSEEPRCPLHLSLP 365

  Fly   415 PAKRQYIQKFY--EVPSTPPVESIFAAGRGLDNFVGEDPRNEPQPEGDDLLDFANGIFDFDLDGV 477
            |...|..|:..  |..::.|.:...:|.             |.||..:..|:|::     ||| |
Zfish   366 PPMYQPEQESLAPEQLASAPTDMYLSAA-------------ELQPTENLPLEFSD-----DLD-V 411

  Fly   478 DDLANSLDDDYSMFLDMDSDLGLAIEDDGVE---SDPVDL--GLEEEGDGGSNDSVGPAESQAQD 537
            :|..........:|     |..||:||..:.   ..|:|:  |.|:          |..::.|||
Zfish   412 EDEGLQCPPSPLLF-----DTALALEDQTIREIAEAPMDILTGAEQ----------GDLDASAQD 461

  Fly   538 NLIADNFELEEPSVQDNNELNFDIDESESNVNEVLRLLE 576
               |:..|.:|.||:|:      :|      .|:|..:|
Zfish   462 ---AELSERDEVSVEDS------VD------TEILEAVE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	24/65 (37%)
dgt1	NP_001287595.1	zf-C3Hc3H	349..411	CDD:290602	23/63 (37%)
kansl2	XP_005162220.1	zf-C3Hc3H	28..92	CDD:290602	25/66 (38%)
kansl2	XP_005162220.1	zf-C3Hc3H	305..362	CDD:290602	22/58 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592812
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CC1T
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32367
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5324
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.830