DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt1 and Ino80d

DIOPT Version :9

Sequence 1:	NP_001287595.1	Gene:	dgt1 / 43529	FlyBaseID:	FBgn0039710	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001178738.1	Gene:	Ino80d / 316440	RGDID:	1304808	Length:	1021	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	153/749 - (20%)
Similarity:	250/749 - (33%)	Gaps:	255/749 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EQIH-SELVKIKYCANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKY 92
            :.|| ||:.....|:.....|...|:.||.:||||:|.|..:.|:||.:|.. |.::|.|.:.|.
  Rat     5 KHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKS 69

  Fly    93 DNKK--ELILTTLCFEHNRQTQLQKTHMNVGRIRSRVE------TNETLLHSLSSHINVEDIKPE 149
            ::::  ...|..|.|...::.:.:...::..::|.:::      |..||...:.:.::...:.|.
  Rat    70 EDRRYCNSHLQVLGFIPKKERKKKNDPVDEVKVRHQMDAMAFSLTVPTLALKMPNGLDSMSLSPP 134

  Fly   150 VKKI----------------ERDDD-----------------------EIDVVS----------- 164
            ..::                |.|||                       |.:::.
  Rat   135 GARVPLHYLETELEDPFAFNEEDDDLKKGVTVRKKLQSKLAQNRQRQRETEILKVRQEHFSTPPT 199

  Fly   165 -----PHVTPFVT----------------QDHRNSI--------GHVVESSRK--RRRILDYASD 198
                 .|::|..|                |....|:        .|.:..:|:  .:|.|.....
  Rat   200 PPQQHAHLSPLPTSLKPPAPPQGSVCKSPQPQSTSLPMQGVAPTTHSIAQTRQASHKRPLPLLPS 264

  Fly   199 SSSNDADPP-----------------CLRNTAQDIEFYESDHESIDSEDDDPLKHAGVFTRAEAV 246
            |.:..:|.|                 |:....:.::.....|:.    |.|...|.|:....|:.
  Rat   265 SRAPVSDTPRTDRILMKATAFSPHFSCISRLQRLVKLCTQKHQL----DADLFPHLGLDWSEESG 325

  Fly   247 KIAETKLIKLQGLYREQISYLQ------NVLRQRRRKYLHDIRRERE----LYCSIHDQLKDTPH 301
            :..|..         :|.|..|      ..|||.|.....|....|.    ..|:...|  ...|
  Rat   326 EELEDS---------DQASPYQVAWSVRETLRQERHTSDDDDAESRSSRVTQLCTYFQQ--KYKH 379

  Fly   302 ----ERKLYEQLKALNSYHRRQGVEAVLYKKLKE-----------KRA---RDALYAAK-SSSNP 347
                ||....|.|..:::.:     |:|....||           :||   ||:|...| ....|
  Rat   380 LCRLERAESRQKKCRHTFRK-----ALLQAASKEPECTGQLIQELRRAACSRDSLSQTKLKEVEP 439

  Fly   348 -KCVFTEGGVKCGERTLPCCKHCRKHILEDKRQVLFRACGVE-RSGVVCQEPVASIL-------- 402
             .|..|..|.:|..:.||..:||.:|||.::.|.||.:|..: ..|..|..||..|.
  Rat   440 AACSGTVKGEQCTNQALPFTRHCFQHILLNRSQQLFSSCTAKFADGQQCSVPVFDITHQTPLCEE 504

  Fly   403 -----------EDSSCVLH--------LTVAPA-KRQYIQKFYEVPSTP--PVESIFAAGR-GLD 444
                       ::|..|.|        .|..|| .:::.:|....|..|  |:......|. .:.
  Rat   505 HAKKMDNFLRGDNSRKVQHQQQRKPRKKTKPPALTKKHKKKRRRGPRRPQKPIPPAVPQGNLSMP 569

  Fly   445 NFVG--------EDPRNEPQPEGDDLL-DFANGIFDF--DLD-GVDDLANSL----DD--DYSMF 491
            ..|.        ..| :.|:...|:|. |.||.|.|.  ||: ..:|.|:.|    ||  |:..|
  Rat   570 TSVSLPVQASQIRSP-STPELSADELPDDIANEITDIPHDLELNQEDFADVLPRLPDDLQDFDFF 633

  Fly   492 --------------------------LDMDSDLGLAIEDDGVESDPVDLGLEEEGDG---GSNDS 527
                                      |:..|.:|:..:.|||   ||. ||.:.|.|   ...|:
  Rat   634 EGKNGDLLPTTEEAEELERALQAVTSLECLSTIGVLSQSDGV---PVQ-GLSDRGMGVFSTGTDA 694

  Fly   528 VGPAESQAQDN----------LIADNF---ELEE 548
            .|......:.|          ::.|:|   ||:|
  Rat   695 SGIQSLSREVNTDLGELLNGRIVHDSFSSLELDE 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	22/67 (33%)
dgt1	NP_001287595.1	zf-C3Hc3H	349..411	CDD:290602	23/89 (26%)
Ino80d	NP_001178738.1	zf-C3Hc3H	18..79	CDD:404731	19/60 (32%)
		PRK14971	<170..>285	CDD:237874	13/114 (11%)
		zf-C3Hc3H	442..506	CDD:404731	20/63 (32%)
		Herpes_BLLF1	<908..>1021	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11071
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010