DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dgt1 and Kansl2

DIOPT Version :9

Sequence 1:	NP_001287595.1	Gene:	dgt1 / 43529	FlyBaseID:	FBgn0039710	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001004244.2	Gene:	Kansl2 / 300206	RGDID:	1303127	Length:	488	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	164/515 - (31%)
Similarity:	242/515 - (46%)	Gaps:	108/515 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKYDNKKELILTTLCF 105
            |:.....||..|:||.|:|::|||.|..:.|:|||::.: ||::|.:|..|.:.|..:   :.|.
  Rat    28 CSFTHRPCSQPRLEGQEFCLKHILEDKNAPFKQCSYISTKNGKRCPSAAPKPEKKDGV---SFCA 89

  Fly   106 EHNRQTQL----QKTHMNVGRIRSRVETNETLLHSLSSHINVEDIKPEVKKIERDDDEIDVVSPH 166
            ||.|:..|    |....|.|.:      .||||..|||:...|
  Rat    90 EHARRNALALHAQMKKSNPGPM------GETLLCQLSSYAKTE---------------------- 126

  Fly   167 VTPFVTQDHRNSIG-HVVESSR-KRRRILDYASDS-SSNDADPPCLRNTAQDIEFYESDHESIDS 228
                        :| ...|||| :..||||  .|| |..|.:|..:..|.:...  :|:.:||||
  Rat   127 ------------LGSQTPESSRSEASRILD--EDSWSDGDQEPITVDQTWRGDP--DSEADSIDS 175

  Fly   229 EDDDPLKHAGVFTRAEAVKIAETKLIKLQGLYREQISYLQNVLRQRRRKYLHDIRRERELYCSIH 293
            :.:||||||||:|..|...|...|||:||.||.:|...||::|::::|:|||:.:.|.|   ::.
  Rat   176 DQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHE---ALG 237

  Fly   294 DQLKDTPH-----ERKLYEQLKALNSYHRRQGVEAVLYKKLKEKRARDALYAAKSS----SNPKC 349
            ..|...|.     ||:..::||.|..|.:|.||||:|:::|||:|......||:.:    |:.:|
  Rat   238 SSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATEGAAQQAHTTRSSQRC 302

  Fly   350 VFTEGGVKCGERTLPCCKHCRKHILEDKRQVLFRAC-GVERSGVVCQEPV-ASILEDSSCVLHLT 412
            :.....|:|..::||..:||..||.:|..||||:.| |.|.  |.|.:|| .|:.||..|.||..
  Rat   303 LAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEE--VPCNKPVPVSLSEDPCCPLHFQ 365

  Fly   413 VAPAKRQYIQKFYEVPSTP------PVESIFAAGRGLDNFVGEDPRNEPQPEGDDLLDFANGIFD 471
            :.|    .:.|..:|.|.|      |::...:|.             |.||.....|:.::
  Rat   366 LPP----QMYKPEQVLSVPDGLEAGPMDLYLSAA-------------ELQPTESLPLELSD---- 409

  Fly   472 FDLDGVDDLANSLDDDYSMFLDMDSDLGLAIEDDGVESDPVDLG-LEEEGDGGSNDSVGP 530
             |||.|.|   .:....|..|   .|..|.:||..|.......| ::..|||..  |.||
  Rat   410 -DLDVVGD---GMPCPPSPLL---FDPSLTLEDHSVTEIAGGPGQIQVAGDGCR--SQGP 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	23/65 (35%)
dgt1	NP_001287595.1	zf-C3Hc3H	349..411	CDD:290602	26/63 (41%)
Kansl2	NP_001004244.2	zf-C3Hc3H	28..92	CDD:404731	24/66 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..182		22/58 (38%)
		zf-C3Hc3H	307..364	CDD:404731	25/58 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351070
Domainoid	1	1.000	99	1.000	Domainoid score	I6947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32367
Inparanoid	1	1.050	180	1.000	Inparanoid score	I3904
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	1	1.000	-	-		FOG0009923
OrthoInspector	1	1.000	-	-		oto96780
orthoMCL	1	0.900	-	-		OOG6_108516
Panther	1	1.100	-	-	LDO	PTHR13453
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7615
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900