DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt1 and ino80d

DIOPT Version :9

Sequence 1:	NP_001287595.1	Gene:	dgt1 / 43529	FlyBaseID:	FBgn0039710	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_002936433.3	Gene:	ino80d / 100493655	XenbaseID:	XB-GENE-6041462	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	703	Identity:	137/703 - (19%)
Similarity:	228/703 - (32%)	Gaps:	251/703 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EQIH-SELVKIKYCANPTYECSLMRIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKY 92
            :.|| ||:.....|:.....|...|:.||.:||||:|.|..:.|:||.:|.. |.::|.|.:.|.
Frog     5 KHIHFSEVDNKPLCSYSPKLCKQRRLNGYAFCIRHVLEDKTAPFKQCEYVAKYNSQRCTNPIPKS 69

  Fly    93 DN--------------------KKELILTTLCFEHNRQTQ--------LQKTH----MNVGRIRS 125
            ::                    ||...|..:...|..:|.        |:..:    ||:....:
Frog    70 EDRRYCNSHLQVLGFIPKKERKKKNDALEDVKARHQMETMAFSLTVPPLKMPNGLDGMNLSPPGA 134

  Fly   126 RVETN--ETLLHSLSSHINVEDIKPEVKKIE-----------------RDDDEIDV----VSPHV 167
            |:..|  ||   .|....:.|:.|.|:||..                 |:.:.::|    .|||.
Frog   135 RLPINYLET---DLEDPFSFEEEKQELKKGTSVKKKLQSKLAQNRQRLRETEIVNVHQEHFSPHP 196

  Fly   168 ------TPFVTQDH---------------------------------------RNSIGHVVESSR 187
                  :|.:.:.|                                       .|::......|.
Frog   197 APSPLHSPSLQEQHALVQPISTLSKPTGIPQNLVCKSPQPPNTSQPVQGVSPVTNTVAQTRHQSS 261

  Fly   188 KRR-RILDYASDSSSND-------ADPP--------------CLRNTAQDIEFY---------ES 221
            ||. .:|...::....|       |.|.              |.|....|.:.:         :|
Frog   262 KRPFSVLPPVTELPRTDRIQLAATALPAYSYYVSRLQRLVKLCTRKQQLDTDLFPHFGLDWSEDS 326

  Fly   222 DHESIDSEDDDPLKHAGVFTRA-----EAVKIAE-----TKLIKLQGLYREQISYLQNVLRQR-- 274
            ..|..||:...|.:.|..|..:     :.:.|.|     :::.:|...::::..:|..:.|..
Frog   327 GEEQEDSDQTSPYRTAWSFRESFQYDCKKLDIEEAHGRSSRIAQLCTYFQQKYKHLCRLERAESC 391

  Fly   275 RRKYLHDIRRERELYCSIHDQLKDTPHERKLYEQLKALNSYHRRQGVEAVLYKKLKEKRARDALY 339
            ::||.|..||..:     ...|::.....:|.::|:.......|.     :..:|:|...
Frog   392 QKKYRHTFRRALQ-----QAALREPETTGQLLQELRRTTCIRTRP-----IQPELRETEV----- 441

  Fly   340 AAKSSSNPKCVFTEGGVKCGERTLPCCKHCRKHILEDKRQVLFRACGVE-RSGVVCQEPVASILE 403
                   ..|..|.....|..|.||..::|.:|||.:..|.||.:|..: ..|..|..||..|
Frog   442 -------TLCSATISNRTCKNRALPYSRNCFQHILSNSSQQLFSSCTAKFADGQQCSVPVFDI-- 497

  Fly   404 DSSCVLHLTVAPAKRQYIQKFYEVPSTPPVESIFAAGRGLDNFVGED------------PRNE-- 454
                 :|.|  |...::.:|                   :|||:..|            ||.:
Frog   498 -----IHQT--PLCEEHAKK-------------------MDNFLRGDNSRKVQHQQQRKPRKKTK 536

  Fly   455 ------------------PQ-------PEGD----DLLDFANGIFDFDLDGVDDLA-NSLDDDY- 488
                              ||       |:|:    ..|.....:.........||: ..|.||.
Frog   537 PPALTKKNKKKRRRGPRRPQKPIPPAVPQGNLCMPSSLSLPMEVSSLRSPSTPDLSTEELPDDIT 601

  Fly   489 SMFLDMDSDLGLAIED--DGVESDPVDLGLEEEGD--GGSNDSVGPAESQAQD 537
            |...|:..||.|..||  |.:...|.||   ::.|  .|.|..:.|...:|::
Frog   602 SEITDIPHDLELNQEDFSDVLPRLPDDL---QDFDFFEGKNGELLPTTEEAEE 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	22/85 (26%)
dgt1	NP_001287595.1	zf-C3Hc3H	349..411	CDD:290602	19/62 (31%)
ino80d	XP_002936433.3	zf-C3Hc3H	18..79	CDD:404731	19/60 (32%)
ino80d	XP_002936433.3	zf-C3Hc3H	444..508	CDD:404731	22/72 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10603
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920