DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dgt1 and kansl2

DIOPT Version :9

Sequence 1:	NP_001287595.1	Gene:	dgt1 / 43529	FlyBaseID:	FBgn0039710	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_001096493.1	Gene:	kansl2 / 100125116	XenbaseID:	XB-GENE-972363	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	172/563 - (30%)
Similarity:	258/563 - (45%)	Gaps:	141/563 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ANPTYECSLM-------RIEGYEYCIRHILRDPRSNFRQCSHVYS-NGRKCINAVAKYDNKKELI 99
            ||.|..||..       ||||:::||:|||.|..:.::|||::.: |||:|.||..|.|.|..:
Frog    22 ANETLSCSFTHRPCSQPRIEGHDFCIKHILEDRNAPYKQCSYISTKNGRRCSNAAPKPDKKDGV- 85

  Fly   100 LTTLCFEHNR------QTQLQKTHMNVGRIRSRVETNETLLHSLSSHINVEDIKPEVKKIERDDD 158
              :.|.||.|      |.|::|:  |.|      .|:|:||:.|:::.
Frog    86 --SFCAEHARRNALALQAQIKKS--NPG------PTSESLLYQLNTYA----------------- 123

  Fly   159 EIDVVSPHVTPFVTQDHRNSIG-HVVESSRKRR-RILDYASDS-SSNDADPPCLRNTAQ-DIEFY 219
                             |:.:| .:.||||... ||||  .|| |.:|.|...:..|.: |:
Frog   124 -----------------RSELGSQIQESSRSEACRILD--EDSLSESDQDTVTVDQTWRGDL--- 166

  Fly   220 ESDHESIDSEDDDPLKHAGVFTRAEAVKIAETKLIKLQGLYREQISYLQNVLRQRRRKYLHDIRR 284
            :|:.:|:||:.:||||||||:|..|...|...|||:||.||.:|...||::|::::|.|||.::.
Frog   167 DSEADSLDSDQEDPLKHAGVYTAEEVTLIMREKLIRLQSLYIDQFKRLQHLLKEKKRNYLHTLKT 231

  Fly   285 ERELYCSIHDQLKD-----TPHERKLYEQLKALNSYHRRQGVEAVLYKKLKEKR------ARDAL 338
            |.|   ::...|..     |..||:...:||||..|.:|.||||:|:::|||:|      |....
Frog   232 EHE---TVGSSLLTGSEGLTFKERECLRRLKALRRYRKRYGVEALLHRQLKERRMLASEGASQQA 293

  Fly   339 YAAKSSSNPKCVFTEGGVKCGERTLPCCKHCRKHILEDKRQVLFRAC-GVERSGVVCQEPV-ASI 401
            :..:||.  :|:.....|:|....||..:||..||.:|..||||:.| |.|  .|.|.:|| .|:
Frog   294 HTTRSSQ--RCMAFIDDVRCSNSCLPMTRHCVSHICQDSSQVLFKLCSGSE--DVACNKPVPLSL 354

  Fly   402 LEDSSCVLHLTVAPAKRQYIQKFYEVP---STPPVESIFAAGRGLDNFVGEDPRNEPQPEGDDLL 463
            .|:..|:||..: |:.....:....||   ...|||...:..             |.||..:..|
Frog   355 SEEPCCLLHYRL-PSPMYKAEPVLPVPEPMDVTPVELYLSTA-------------ELQPTENLPL 405

  Fly   464 DFANGIFDFDL--DGVD------------DLANSLD-DDYSMFLDMDSDLGLAIEDDGVESDPVD 513
            :|::   |.|:  ||:.            |::..|| .:|.....|.|.| |...|..|
Frog   406 EFSD---DLDVVGDGMQFPPSPLLFDPSADISRPLDSQEYEKHRTMASHL-LLTADSLV------ 460

  Fly   514 LGLEEEGDGGSNDSVGPAESQAQDNL-IADNFELEEPSVQDNN 555
                  |..|.    |..::.|..:| :.||......|..:.|
Frog   461 ------GSAGQ----GQVQTAAASSLHLTDNATESSLSTPNGN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dgt1	NP_001287595.1	zf-C3Hc3H	42..107	CDD:290602	28/71 (39%)
dgt1	NP_001287595.1	zf-C3Hc3H	349..411	CDD:290602	25/63 (40%)
kansl2	NP_001096493.1	zf-C3Hc3H	28..92	CDD:372789	26/66 (39%)
kansl2	NP_001096493.1	zf-C3Hc3H	307..363	CDD:372789	23/57 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6735
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32367
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172254at2759
OrthoFinder	1	1.000	-	-		FOG0009923
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13453
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7615
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.110