DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad99C and DCHS1

DIOPT Version :10

Sequence 1:NP_733314.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster
Sequence 2:NP_003728.1 Gene:DCHS1 / 8642 HGNCID:13681 Length:3298 Species:Homo sapiens


Alignment Length:1459 Identity:385/1459 - (26%)
Similarity:590/1459 - (40%) Gaps:272/1459 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 QPTTPPELPIFG-DPDTEIALNLVF---PKGQPIFQLNGK--KLQLLQPLDRDEENLSHIVFQVS 114
            ||..|..|.:.. |||...|..:.:   ..|...|:|:..  .|.:::|||| |:...|::..|:
Human  1558 QPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDR-EQRAEHVLTVVA 1621

  Fly   115 CTTRSTGKKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVE 179
            ....|..:..|..:.|.|:|:||.||.|....|.|.:.|:.|.||::. .::|.|.|.|.||.|.
Human  1622 SDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLL-TLRATDPDVGANGQVT 1685

  Fly   180 YFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRL 244
            |    |..:|   |.:|.|         |..|.:|..:.||.|:.:...||:.|.|  |.:..:|
Human  1686 Y----GGVSS---ESFSLD---------PDTGVLTTLRALDREEQEEINLTVYAQD--RGSPPQL 1732

  Fly   245 SSTTTLTVNIADSNDLDPSFIYSGCVSLDGACINPEYSASVPAGSLLGVLTVLPERIQAVDLDT- 308
            :. .|:.|.:.|.||..|:|   |...|         |..||.|.....||:|    :|.|.|. 
Human  1733 TH-VTVRVAVEDENDHAPTF---GSAHL---------SLEVPEGQDPQTLTML----RASDPDVG 1780

  Fly   309 INSPIRYSFASGMPGNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAKL 373
            .|..::|....|.|   :..|.:|.::|.....:.:|......:.:.::|.:   |.|...:|.|
Human  1781 ANGQLQYRILDGDP---SGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARD---GGQPALSATL 1839

  Fly   374 EIFVKPVDANP-----PVISSSQAEGYVDENSPIGTRV--LDAHGNPISFMTTDADLSDSDPKPD 431
            .:.|..:|||.     ||.:.|..   |.|:.|.||.:  |.||         |.|...:.....
Human  1840 LLTVTVLDANDHAPAFPVPAYSVE---VPEDVPAGTLLLQLQAH---------DPDAGANGHVTY 1892

  Fly   432 YIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPL----SLTVHLRD 492
            |:...|..:|.:......:.....|||: ..|. :.|.|.|.:   .||:.||    |:|:.:||
Human  1893 YLGAGTAGAFLLEPSSGELRTAAALDRE-QCPS-YTFSVSAVD---GAAAGPLSTTVSVTITVRD 1952

  Fly   493 VNDNAPKLAMVAPISITAGDQSES------RLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFT 551
            |||:||... .:|:.:.......|      .|.| :.|.|.|.|.||.:.|.:......|.   |
Human  1953 VNDHAPTFP-TSPLRLRLPRPGPSFSTPTLALAT-LRAEDRDAGANASILYRLAGTPPPGT---T 2012

  Fly   552 INATTGEIRTQGR--LLAGEQYSITVQATDIG--GLSSQAIVEVSVTPGPNTKPPRFQKPIYEVQ 612
            :::.|||||....  .|......:.:.|||:|  ..|:..::.|.: .|...:.|||.:...|..
Human  2013 VDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGL-QGEAERGPRFPRASSEAT 2076

  Fly   613 VSEGAEINSTVT---VVHAEDPENDAVVYSIISGNDLRQFAVGQESGVIIV--IRKLDRESLTRY 672
            :.|.|...:.:.   .||| ...|..:.|||:|||:...|::...:|.|.|  ...||.|...|.
Human  2077 IRENAPPGTPIVSPRAVHA-GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRL 2140

  Fly   673 QLILKAEDTGGLSSSATVNIKVTDINDKNPEFEASTLPY--VFQVEEGKAQASVGVVHATDADEG 735
            :|:|:|| :||..:...:.:.:.|.||..|.|   ..|:  .|..|....:..:..|.|.|.|:|
Human  2141 RLVLQAE-SGGAFAFTVLTLTLQDANDNAPRF---LRPHYVAFLPESRPLEGPLLQVEADDLDQG 2201

  Fly   736 INAEITYSIPTDIP----FTINATSGEILTAKELDYEQLNEYKFVVTAKDGAPDARLGTASVTVM 796
            ...:|:||:....|    |.::.|:|.|.|...||.|...|.:.|:.|.|....|.:|:|::|||
Human  2202 SGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVM 2266

  Fly   797 VLDLPDE---VPKFSDARIDVHIPENEENFL---VATVQAFDPDSMPEITYVLR-KGNAELFKVS 854
            |:|..|.   :|:..:.|:      :|:..|   :|.|...|.||.|.:.|||. .|..:.|.|.
Human  2267 VIDTNDNRPTIPQPWELRV------SEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVG 2325

  Fly   855 EKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTILLVVDVEDRNDLPPRFITVPDPVTVND 919
            ...|.|.....||:|...::||.:  :.:||...|...|.|: |||.||..|.|......|.:.:
Human  2326 RYGGRVSLTGPLDFEQCDRYQLQL--LAHDGPHEGRANLTVL-VEDVNDNAPAFSQSLYQVMLLE 2387

  Fly   920 DQGIGTIIATLPAIDGDGTSPGNVVRYEIVGRGKAPKYFQVDPDTGAV-RIRDELRKEEDTEYQV 983
            ....|:.|.::.|.|.|..:.|: :.|.:......   |.|||:.|.: .|...:....|....|
Human  2388 HTPPGSAILSVSATDRDSGANGH-ISYHLASPADG---FSVDPNNGTLFTIVGTVALGHDGSGAV 2448

  Fly   984 DI--RAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTSV 1046
            |:  .|.|.|.|..::    |..||..|...|:...                  :|:...|..:|
Human  2449 DVVLEARDHGAPGRAA----RATVHVQLQDQNDHAP------------------SFTLSHYRVAV 2491

  Fly  1047 PESMEANSTLKLIQIVNSKTSGDGP---PAFRCEFVSGNGGGIFNL--------SSADH-----G 1095
            .|.:...|||..::    .|..||.   .|.....:|||.|.:|.|        .||..     |
Human  2492 TEDLPPGSTLLTLE----ATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALG 2552

  Fly  1096 CNLLLIQPLDFENKSSYSLQLRLTSHRYFVNPLKDTTSVEIIVQDENDNAPEFEFNRLRGQQDTF 1160
            | |:|::|||||:.:.|:|.:.......  .|......|.:.|.|.|||.|.|       .:.::
Human  2553 C-LVLLEPLDFESLTQYNLTVAAADRGQ--PPQSSVVPVTVTVLDVNDNPPVF-------TRASY 2607

  Fly  1161 YTVVTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFK 1225
            ...|.|:..|...:|.|.|:|.|.|..|.||:|:...|      |:..|.:.|.:|.||.|....
Human  2608 RVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGD------PSGLFELDESSGTLRLAHALD 2666

  Fly  1226 NENDFPLTFLVEARDSDGQEQGSHRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLD 1290
            .|.......:|:|.|    ..|:|...|.:.: ::.|:|....:||                   
Human  2667 CETQARHQLVVQAAD----PAGAHFALAPVTI-EVQDVNDHGPAFP------------------- 2707

  Fly  1291 KKTGLVSGIERMSSQKYLAKNGSVIEN--PAATDIWFYLIDPKTEQLVSRKDSIVETTLLEPAAR 1353
                    :..:|:        ||.||  |.......:.||.........:.|::|.   .|...
Human  2708 --------LNLLST--------SVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEA---GPGPE 2753

  Fly  1354 SELNIALPRATAE---NISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYIC 1415
            .....||..:|.|   .:.|..|..|....:..|....|       ::.|:.:.:|         
Human  2754 GREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN-------LSASVTVSVL--------- 2802

  Fly  1416 ISWSKYKNFKQRMRQYSSTNPPRYDPVIV 1444
                             .|....||||.:
Human  2803 -----------------VTGEDEYDPVFL 2814

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad99CNP_733314.1 CA_like 68..140 CDD:481204 22/76 (29%)
Cadherin_repeat 146..259 CDD:206637 34/112 (30%)
Cadherin_repeat 280..383 CDD:206637 25/103 (24%)
Cadherin_repeat 393..496 CDD:206637 30/108 (28%)
Cadherin_repeat 518..594 CDD:206637 23/79 (29%)
Cadherin_repeat 608..699 CDD:206637 28/95 (29%)
Cadherin_repeat 710..802 CDD:206637 32/97 (33%)
Cadherin_repeat 814..903 CDD:206637 29/92 (32%)
Cadherin_repeat 915..1005 CDD:206637 22/92 (24%)
Cadherin_repeat 1041..1144 CDD:206637 34/118 (29%)
Cadherin_repeat 1159..1264 CDD:206637 29/104 (28%)
DCHS1NP_003728.1 Cadherin_repeat 49..139 CDD:206637
Cadherin_repeat 150..251 CDD:206637
Cadherin_repeat 260..358 CDD:206637
Cadherin_repeat 374..468 CDD:206637
Cadherin_repeat 482..574 CDD:206637
Cadherin_repeat 583..681 CDD:206637
Cadherin_repeat 689..781 CDD:206637
Cadherin_repeat 794..890 CDD:206637
Cadherin_repeat 900..991 CDD:206637
Cadherin_repeat 1004..1101 CDD:206637
Cadherin_repeat 1114..1207 CDD:206637
Cadherin_repeat 1224..1312 CDD:206637
Cadherin_repeat 1336..1432 CDD:206637
Cadherin_repeat 1445..1542 CDD:206637
Cadherin_repeat 1551..1644 CDD:206637 24/86 (28%)
Cadherin_repeat 1653..1747 CDD:206637 35/113 (31%)
Cadherin_repeat 1757..1851 CDD:206637 27/103 (26%)
Cadherin_repeat 1860..1956 CDD:206637 31/112 (28%)
Cadherin_repeat 1983..2056 CDD:206637 22/76 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2065..2094 6/28 (21%)
Cadherin_repeat 2074..2167 CDD:206637 29/94 (31%)
Cadherin_repeat 2175..2273 CDD:206637 31/97 (32%)
Cadherin_repeat 2282..2372 CDD:206637 31/98 (32%)
Cadherin_repeat 2381..2478 CDD:206637 26/104 (25%)
Cadherin_repeat 2486..2598 CDD:206637 34/118 (29%)
Cadherin_repeat 2606..2702 CDD:206637 30/106 (28%)
Cadherin_repeat 2712..2808 CDD:206637 23/139 (17%)
Cadherin_repeat 2818..2923 CDD:206637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2986..3040
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3062..3082
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3233..3298
Blue background indicates that the domain is not in the aligned region.

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