Protein Alignment Cad99C and PCDH11Y

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: NP_116755.1
• Gene: PCDH11Y / 83259
• HGNCID: 15813
• Length: 1340
• Species: Homo sapiens
• Alignment Length: 1201
• Identity: 291/1201 - (24%)
• Similarity: 475/1201 - (39%)
• Gaps: 281/1201 - (23%)

  Fly    71 TEIALNLVFPKGQ-PIFQL---------NGKKL---QLLQPLDRDEENLSHIVFQVSCTTRSTGK 122
            |.:...||:..|. |:.::         .|.::   :|...:.|||    |..::|.........
Human    91 TTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAGIPRDE----HCFYEVEVAILPDEI 151

  Fly   123 KRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSP 187
            .|.:.|...:.|||||||.|..|...:::||::.:.:. :....|:|.|.|:||:..|.:.:
Human   152 FRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK-YTLPAAVDPDVGINGVQNYELIK--- 212

  Fly   188 NSTNVEKYSADGYGTFAISFPH---QGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTT 249
             |.|:       :|...|..|.   ..|:.|.|.||.|:..||.:.:...|   ....:.|||..
Human   213 -SQNI-------FGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVED---GGFPQRSSTAI 266

  Fly   250 LTVNIADSNDLDPSFIYSGCVSLDGACINPEYSASVPAGSLLGVLTVLPERIQAVDLDT-INSPI 313
            |.|::.|:||..|.|            ...|...|:|..:.:|....   ::.|.|.|. .|:.|
Human   267 LQVSVTDTNDNHPVF------------KETEIEVSIPENAPVGTSVT---QLHATDADIGENAKI 316

  Fly   314 RYSFASGMPGNYA-DYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFV 377
            .:|| |.:..|.| ..|.::.:||::...:.:|......:.::|.|.:....|.|   |.:.:.|
Human   317 HFSF-SNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR---AMVLVNV 377

  Fly   378 KPVDANPP------VISSSQAEGYVDENSPIGTRV---------LDAHGNPISFMTTDADLSDSD 427
            ..|:.|.|      :::.......:.||.|:.|::         .|.:|....|  ||.::.
Human   378 TDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCF--TDHEIP--- 437

  Fly   428 PKPDYIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLS----LTV 488
                  :.| .|.|:   :..|:.|...||.:  :...:..:::|    .:|...||:    |.:
Human   438 ------FRL-RPVFS---NQFLLENAAYLDYE--STKEYAIKLLA----ADAGKPPLNQSAMLFI 486

  Fly   489 HLRDVNDNAPKLAM-VAPISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTI 552
            .::|.|||||.... ...:||...:....:|: :|:|||.|.||||.:.|.:   ..:...:|::
Human   487 KVKDENDNAPVFTQSFVTVSIPENNSPGIQLM-KVSATDADSGPNAEINYLL---GPDAPPEFSL 547

  Fly   553 NATTGEIRTQGRL--LAGEQYSITVQATDIG--GLSSQAIVEVSVTPGPNTKPPRFQKPIYEVQV 613
            :..||.:....:|  ...::|..|:.|.|.|  .|:|...|.||:. ..|...|.|....|:..|
Human   548 DRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSII-DQNDNSPVFTHNEYKFYV 611

  Fly   614 SEGAEINSTVTVVHAEDP---ENDAVVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLI 675
            .|....:.||.::...||   :|.||..||:..||  .|.:..::|||......|||....|...
Human   612 PENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTIDSQTGVIRPNISFDREKQESYTFY 674

  Fly   676 LKAEDTGGL--SSSATVNIKVTDINDKNPEFEASTLPYVFQVEEGKAQASVGV----VHATDADE 734
            :||||.|.:  ||||.|.|.|.|:||..|.|...  ||.:..|......:.|.    |.|.|.|.
Human   675 VKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVP--PYNYSYELVLPSTNPGTVVFQVIAVDNDT 737

  Fly   735 GINAEITYSI----PTDIPFTINATSGEILTAKELDYEQLNEYKFVVTAKD-GAPDARLGTASVT 794
            |:|||:.|||    ..|: |.|:..:|.|...::.|...|..::.:|.|.| |.||:......|.
Human   738 GMNAEVRYSIVGGNTRDL-FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVIVN 801

  Fly   795 VMVLD-------LPDEVPKFSDARI-------DVHIPENE-ENFLVATVQA--------FDPDSM 836
            :.|.:       :.:.|.|..:|.:       ||..|.:: ...|||.|..        |
Human   802 LFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVKILVAAVAGTITVVVVIF----- 861

  Fly   837 PEITYVLRKGNAELFKVSEKSGE----------------VRTIKGLDYESQKQHQLTIGTIEN-- 883
              ||.|:|...|...|.::|:.:                ::..|.....|.|...|.:.|||.
Human   862 --ITAVVRCRQAPHLKAAQKNMQNSEWATPNPENRQMIMMKKKKKKKKHSPKNLLLNVVTIEETK 924

  Fly   884 ----DGNGPGDTILLVVDVEDRNDLPPRFITVPDPVTVNDDQGIGTIIATLPAIDGDGTSPGNVV 944
                |.:|...|:.|.:|:|::.  ..::..|..|.|...|                  ||....
Human   925 ADDVDSDGNRVTLDLPIDLEEQT--MGKYNWVTTPTTFKPD------------------SPDLAR 969

  Fly   945 RYEIVGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDVHHLL 1009
            .|:......|   ||:.|:|                                   ||.:. ||::
Human   970 HYKSASPQPA---FQIQPET-----------------------------------PLNLK-HHII 995

  Fly  1010 SSGNNEIKLDNKLESGTGM----SSESIGLAFSDDSY---TTSVPESMEANSTLKLIQI----VN 1063
                .|:.|||...:...:    ||.|...:.||..|   |..||.|:....:.:.:..    .:
Human   996 ----QELPLDNTFVACDSISNCSSSSSDPYSVSDCGYPVTTFEVPVSVHTRPSQRRVTFHLPEGS 1056

  Fly  1064 SKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLIQPLDFENKSSYSLQLRLT-SHR----- 1122
            .::|.||.       :..:..|  :|:|..||.      ||.:..:..:.   |.| |:|
Human  1057 QESSSDGG-------LGDHDAG--SLTSTSHGL------PLGYPQEEYFD---RATPSNRTEGDG 1103

  Fly  1123 ------YFVNPLKDTTSVEIIVQDENDNAPE 1147
                  .|:..||...:|:..|::.:||..:
Human  1104 NSDPESTFIPGLKKEITVQPTVEEASDNCTQ 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	19/81 (23%)
		Cadherin_repeat	146..259	CDD:206637	29/115 (25%)
		Cadherin_repeat	280..383	CDD:206637	25/104 (24%)
		Cadherin_repeat	393..496	CDD:206637	23/115 (20%)
		Cadherin_repeat	518..594	CDD:206637	25/79 (32%)
		Cadherin_repeat	608..699	CDD:206637	35/95 (37%)
		Cadherin_repeat	710..802	CDD:206637	30/107 (28%)
		Cadherin_repeat	814..903	CDD:206637	27/119 (23%)
		Cadherin_repeat	915..1005	CDD:206637	12/89 (13%)
		Cadherin_repeat	1041..1144	CDD:206637	24/121 (20%)
		Cadherin_repeat	1159..1264	CDD:206637
PCDH11Y	NP_116755.1	Cadherin_2	60..134	CDD:462413	7/42 (17%)
		Cadherin_repeat	175..277	CDD:206637	30/116 (26%)
		Cadherin_repeat	285..383	CDD:206637	25/104 (24%)
		CA	416..496	CDD:214520	21/100 (21%)
		Cadherin_repeat	504..598	CDD:206637	28/98 (29%)
		Cadherin_repeat	606..701	CDD:206637	36/96 (38%)
		Cadherin_repeat	713..804	CDD:206637	27/91 (30%)
		Protocadherin	807..1008	CDD:462451	51/270 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1052..1112		14/77 (18%)
		FAM47	<1180..1247	CDD:405345
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1321..1340