Protein Alignment Cad99C and Cdhr5

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: NP_001107794.1
• Gene: Cdhr5 / 72040
• MGIID: 1919290
• Length: 831
• Species: Mus musculus
• Alignment Length: 613
• Identity: 160/613 - (26%)
• Similarity: 239/613 - (38%)
• Gaps: 131/613 - (21%)

  Fly     1 MAARNSLTPQQGLGFFGLLILLCSAVLGKSQMCEVETGQTNIILDIEESRESFIGQPTTPPELPI 65
            |.|...|.|...|.:..:|.......|.::|:|.|  .||  |..:||:      ...:.|.:.|
Mouse     1 MGAPALLWPSLLLPWLTVLFGQPPGTLAQTQVCSV--NQT--IFRVEEN------TTVSEPLVNI 55

  Fly    66 FGDPDTEIALNLVFPKGQP-IFQLNGKKLQLLQPLDRDEENLSHIVFQVSCTTRSTGKKRTIPII 129
            |......:.|.   |...| .|::.||.|.|....|.:|.:|  :...|.|       ||...::
Mouse    56 FVPDGLHVTLG---PLSTPYAFRIEGKDLFLNVTPDYEENSL--LQADVEC-------KRGDAVV 108

  Fly   130 VR------VSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPN 188
            ||      |.|||||||:|........|.|.|.|.||:....|....||.:|.::.|.:.|.:||
Mouse   109 VRLEVFVAVLDINDNAPKFSFEIKTFNVSEDTKVNTTVIPETQLKATDADINDILVYTLQEVTPN 173

  Fly   189 STNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDR-ARNTADRLSSTTTLTV 252
            ::..  :|.:|     :::|   .:.:.:|||:.|.|.....::|.|. ..|.....::|.||.:
Mouse   174 ASKF--FSLEG-----VNYP---ALKLDQTLDYFKNQNMTFMLLARDTWEENVEPSHTATATLVL 228

  Fly   253 NIADSNDLDPSFIYSGCVSLDG-ACINPEYSASVPAG-SLLGVLTVLPERIQAVDLD-TINSPIR 314
            |...::...|.|:  .|...|| .||:.:|||.||.| .|...|.:.|..|.|||.| .||..|.
Mouse   229 NTLPADLRTPWFL--PCSFTDGYVCIHAQYSAVVPTGHKLPSPLIMSPGPIYAVDGDQAINQSII 291

  Fly   315 YSFASGMPGNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKP 379
            ||.   :.||....|.|:...|.|..||::  .:..|:.::::|::........|.|.:|  .:.
Mouse   292 YSI---IAGNTDGTFIINAHDGNLTMTKSI--PSPMKFTLLIRADQEDMAQYSVTQAIVE--ARS 349

  Fly   380 VDANPPVISSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDSDPKPDYIYELTTPSFNVT 444
            |..||...|.|...|.|...|..||.|.|.                           |.||
Mouse   350 VTGNPLQFSQSLYYGTVVLGSEAGTAVKDK---------------------------TFPS---- 383

  Fly   445 GDGILVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLAMVAPISIT 509
                     |.|......||         .|..|:|     :|..:    .|:.:..|...|.:|
Mouse   384 ---------EILRIQAQYPG---------FPDLNSA-----VTYRV----TNSSEFMMNKDIMLT 421

  Fly   510 AGDQSESRLV-TQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTGEIRTQGRLLAGEQYSI 573
            |....|:|.: .:|.|                   :|.:.|.|..|.. ||:...|.|...::..
Mouse   422 AVPMEEARTIRVEVEA-------------------SNTVTKDTATAVV-EIQVSERELPSTEFPT 466

  Fly   574 TVQATDIGGLSSQAIVEVSVTPGPNTKP 601
            ..:|....|.||...:|..:|.|.:.:|
Mouse   467 PPEAGGTTGPSSNTTMEAPLTSGTSQRP 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	23/78 (29%)
		Cadherin_repeat	146..259	CDD:206637	29/113 (26%)
		Cadherin_repeat	280..383	CDD:206637	33/104 (32%)
		Cadherin_repeat	393..496	CDD:206637	18/102 (18%)
		Cadherin_repeat	518..594	CDD:206637	15/76 (20%)
		Cadherin_repeat	608..699	CDD:206637
		Cadherin_repeat	710..802	CDD:206637
		Cadherin_repeat	814..903	CDD:206637
		Cadherin_repeat	915..1005	CDD:206637
		Cadherin_repeat	1041..1144	CDD:206637
		Cadherin_repeat	1159..1264	CDD:206637
Cdhr5	NP_001107794.1	Cadherin_repeat	40..123	CDD:206637	26/100 (26%)
		Cadherin_repeat	133..229	CDD:206637	28/105 (27%)
		Cadherin_repeat	255..346	CDD:206637	31/95 (33%)
		Herpes_BLLF1	<437..>619	CDD:282904	17/78 (22%)
		3 X 31 AA approximate tandem repeats	545..618
		Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9HBB8	663..831
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..774
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	793..831