DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad99C and Pcdh15

DIOPT Version :9

Sequence 1:	NP_001189311.1	Gene:	Cad99C / 43528	FlyBaseID:	FBgn0039709	Length:	1706	Species:	Drosophila melanogaster
Sequence 2:	XP_038955032.1	Gene:	Pcdh15 / 690865	RGDID:	1590969	Length:	1940	Species:	Rattus norvegicus

Alignment Length:	1653	Identity:	472/1653 - (28%)
Similarity:	734/1653 - (44%)	Gaps:	279/1653 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CEVETG---QTNIILDIEESRESFI-----------GQPTTPPELPIFGDPDTEIALN------- 76
            |::..|   .|.:.:| ||||...|           |.|          ||..|::|.
  Rat    37 CKLARGGPPATIVAID-EESRNGTILVDNMLIKGTAGGP----------DPTIELSLKDNVDYWV 90

  Fly    77 LVFPKGQPIFQLNGKKLQLLQPLDRDEE-NLSHIVFQVSCTTRSTGK--KRTIPIIVRVSDINDN 138
            |:.|..|.:| ||...    :.||||.. |:..||.||.|..:..|.  ...:.|:||  |.|||
  Rat    91 LLDPVKQMLF-LNSTG----RVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVR--DRNDN 148

  Fly   139 APRFMNTPYEVTVPESTPVGTTIFRNIQ----ALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADG 199
            :|.|.:..|..||.|.||||||||....    |.|.|.|.||.:||.|.....:.|:.:
  Rat   149 SPTFKHESYYATVNELTPVGTTIFTGFAGDNGATDIDDGPNGQIEYVIQYNPEDPTSND------ 207

  Fly   200 YGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSF 264
              ||.|.....|.|.:.|.|::|....||:.|.|:|||:|..:|.::||||||::.|.:||.|.|
  Rat   208 --TFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF 270

  Fly   265 IYSGCVSLDGA--CINPEYSASVP---AGSLLGVLTVLPERIQAVDLD-TINSP-----IRYSFA 318
            :  .||.:...  |....|.|::|   ....|..:.|.|. |||:|.| .|..|     |.||..
  Rat   271 L--PCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPP-IQAIDQDRNIQPPSDRPGILYSIL 332

  Fly   319 SGMPGNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGP-QRFTTAKLEIFVKPVDA 382
            .|.|.:|..:..:...|..|...:.|:....:|:|:::|||:.:..| ..|.:..:||    :|.
  Rat   333 VGTPEDYPRFLHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEI----LDE 393

  Fly   383 N--PPVISSSQAEGYVDENSPIGTRVLDAHG--NPISFMTTDADLSDS-DPKPDYIYELTTPSFN 442
            |  .|..:....:||:.|::|:|..:.::..  .|:..:..|.|:.|: ||:........|..|.
  Rat   394 NNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 458

  Fly   443 VTGDGI--LVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLAMVAP 505
            ||..||  .:...:.:||:...  .:.|.:.|.:....  |.|:.:.:.:.|.|||.|....::.
  Rat   459 VTPTGITRYLTLLQPVDREEQQ--TYTFLITAFDGVQE--SEPVVVNIRVMDANDNTPTFPEISY 519

  Fly   506 ISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTG--EIRTQGRLLAG 568
            ......|.|....|.|:||.|.|||.|..::|.|. |.:.|  .|.||.|||  .|.....|:.|
  Rat   520 NVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEIL-VGSKG--DFVINRTTGLVSIAPGVELVVG 581

  Fly   569 EQYSITVQATDIGGLS----SQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAE 629
            :.|::||||:|....:    |...|.:.|.|..|..||||.:.:|.::|||...|.:.:..:.|.
  Rat   582 QTYALTVQASDNAPPAERRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAVLLNLQAT 646

  Fly   630 DPENDAVVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLILKAED--TGGLSSSATVNI 692
            |.|.|.:.|:|.:|:..|.|.:.:.:|::.:.:.|||||..||.||:.|.|  ..| :|:|||||
  Rat   647 DREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDG-TSTATVNI 710

  Fly   693 KVTDINDKNPEFEASTLPYVFQVEEGKAQASVGVVHATDADEGINAEITYSIPTDIPFTINATSG 757
            .|||:||..|.|: ..||....|.|.:|.|.||.|.|||.|.|||.::.||:..........::|
  Rat   711 VVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNG 774

  Fly   758 EILTAKELDYEQLNEYKFVVTAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENEEN 822
            .|.||.:|:.|..:.|:.||.|.|||...|..|.::.:.|||:.|..|.|:::...|.:   |||
  Rat   775 SIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVV---EEN 836

  Fly   823 FLVAT----VQAFDPDSMPEITYVLRKGNAE-LFKVSEKSGEVRTIKGLDYESQKQHQLTI---- 878
            ....|    ::|.|.|....::|.:|....: ||.:...:||:..::.||||:....:.:|
  Rat   837 LPAGTAFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLV 901

  Fly   879 ------GTIENDGNGPGDTILLVVDVEDRNDLPPRF-------ITVPDPVTVNDDQGIGTIIATL 930
                  ||:.     ||...:.|: |:|.||.||.|       :..||.|.       ||.|.|:
  Rat   902 EAFDIYGTMP-----PGIATVTVI-VKDMNDYPPVFSKRIYKGMVAPDAVK-------GTPITTV 953

  Fly   931 PAIDGDGTS-PGNVVRYEI--VGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGE 992
            .|.|.|... |.:.|||.:  |........|.|:.|:|.|..|..|.:|..|.:::.:.|:|.||
  Rat   954 YAEDADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE 1018

  Fly   993 PQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTLK 1057
            |.:||.|.:|:.|.|     ..||.                  .|:.:.|.......:.|..|:.
  Rat  1019 PVMSSSATVRILVLH-----PGEIP------------------RFTQEEYRPPPVSELAARGTVV 1060

  Fly  1058 LI--------QIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLIQPLDFENKSSYSL 1114
            .:        .||.|..:|:....|          ||.|::..     :.:..|||:|.::||.|
  Rat  1061 GVISAAAINQSIVYSIVAGNEDDKF----------GINNVTGV-----IYVNSPLDYETRTSYVL 1110

  Fly  1115 QLRLTSHRYFVNPLK-----DTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYT-VVTEEMDVDTT 1173
            :::..|....:..|:     :|..|.|.:|||||:.|.|        |..||. .|:|:..:.|:
  Rat  1111 RVQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVF--------QKKFYIGGVSEDARMFTS 1167

  Fly  1174 ILQVRATDRDSGKFGTVRYTLYDDDENRVNMP-----TSFFMMSEDTGVLRTAKHFKNENDFPLT 1233
            :|:|:|||||:|.:..:.|        |:.:|     ...|::...||:::||..|.|.......
  Rat  1168 VLRVKATDRDTGNYSAMAY--------RLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1224

  Fly  1234 FLVEARDSDGQEQGSHRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKT----- 1293
            |.|.|.|..|:...........|||:|    .|.:...|..|:.:.....:|.|:||:..
  Rat  1225 FQVIATDDYGKGLSGKADVLVSVVNQL----DMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1285

  Fly  1294 GLVSGIERMSSQKYLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKD--SIVETTLLE-----PA 1351
            |....:|.:.::::  .:...:|:.:..|:..|.|||:|.:.:.|.:  ..::..||:     ..
  Rat  1286 GAKVVVESIGARRH--GDAFSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQP 1348

  Fly  1352 ARSELNIALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYICI 1416
            ...|....|...|.|.::...:|.|.:...:.|           |:|::.:|::.....|:.:.:
  Rat  1349 YYGEGGRILEIRTPEAVTSIKKRGESLGYTEGA-----------LLALAFIIILCCIPAILVVLV 1402

  Fly  1417 SWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASETIANMKEYETQMLAMAVPPDVDDD---- 1477
            |   |:.||  :||...|...|.      |.|..|::..|.:.         |.||.....
  Rat  1403 S---YRQFK--VRQAECTKTARI------QSAMPAAKPAAPVP---------AAPPPPPPPPPPG 1447

  Fly  1478 ----LQLDFSAKNHAFSLDNVSYITHKENTNGGG---QSSPSHSDATTATIATLRRHKNLNNASM 1535
                .:|..||.::.|.|      .|.|.:.|..   :...||.|....:.:|...|:..:....
  Rat  1448 AHLYEELGESAMHNLFLL------YHFEQSRGNNPVPEDRSSHRDGMAFSSSTTESHEPAHVEGP 1506

  Fly  1536 NNNLAINNRQNTFNRTLEMNTRNNANPL 1563
            .:|.|  |...||:...:.:..:..|||
  Rat  1507 LDNQA--NPARTFSFLPDEDDLSTHNPL 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_001189311.1	Cadherin_repeat	<68..138	CDD:206637	26/79 (33%)
		Cadherin_repeat	146..259	CDD:206637	46/116 (40%)
		Cadherin_repeat	280..383	CDD:206637	32/112 (29%)
		Cadherin_repeat	393..496	CDD:206637	25/107 (23%)
		Cadherin_repeat	518..594	CDD:206637	30/81 (37%)
		Cadherin_repeat	608..699	CDD:206637	36/92 (39%)
		Cadherin_repeat	710..802	CDD:206637	35/91 (38%)
		Cadherin_repeat	814..903	CDD:206637	26/103 (25%)
		Cadherin_repeat	915..1005	CDD:206637	31/92 (34%)
		Cadherin_repeat	1041..1144	CDD:206637	27/115 (23%)
		Cadherin_repeat	1159..1264	CDD:206637	32/110 (29%)
Pcdh15	XP_038955032.1	ECD	36..145	CDD:408229	35/125 (28%)
		Cadherin_repeat	156..245	CDD:206637	37/96 (39%)
		CA	310..398	CDD:214520	26/91 (29%)
		Cadherin_repeat	404..510	CDD:206637	25/109 (23%)
		Cadherin_repeat	518..614	CDD:206637	34/98 (35%)
		Cadherin_repeat	626..718	CDD:206637	37/92 (40%)
		Cadherin_repeat	727..820	CDD:206637	35/92 (38%)
		Cadherin_repeat	828..926	CDD:206637	26/106 (25%)
		Cadherin_repeat	935..1032	CDD:206637	33/103 (32%)
		Cadherin_repeat	1050..1145	CDD:206637	26/109 (24%)
		Cadherin_repeat	1154..1248	CDD:206637	27/101 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10435
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23401
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2029
OMA	1	1.010	-	-		QHG47650
OrthoDB	1	1.010	-	-		D15091at33208
OrthoFinder	1	1.000	-	-		FOG0005384
OrthoInspector	1	1.000	-	-		oto97318
orthoMCL	1	0.900	-	-		OOG6_109439
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880