DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad99C and PCDH15

DIOPT Version :9

Sequence 1:	NP_001189311.1	Gene:	Cad99C / 43528	FlyBaseID:	FBgn0039709	Length:	1706	Species:	Drosophila melanogaster
Sequence 2:	NP_001136235.1	Gene:	PCDH15 / 65217	HGNCID:	14674	Length:	1962	Species:	Homo sapiens

Alignment Length:	1820	Identity:	489/1820 - (26%)
Similarity:	776/1820 - (42%)	Gaps:	326/1820 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GLLILLCSAVLG------KSQMCEVETG---QTNIILDIEESRESFI-----------GQPTTPP 61
            |.|..:|   ||      :.:.|::..|   .|.:.:| ||||...|           |.|
Human    18 GSLFEIC---LGQYDDDWQYEDCKLARGGPPATIVAID-EESRNGTILVDNMLIKGTAGGP---- 74

  Fly    62 ELPIFGDPDTEIALN-------LVFPKGQPIFQLNGKKLQLLQPLDRDEE-NLSHIVFQVSCTTR 118
                  ||..|::|.       |:.|..|.:| ||...    :.||||.. |:..||.||.|..:
Human    75 ------DPTIELSLKDNVDYWVLMDPVKQMLF-LNSTG----RVLDRDPPMNIHSIVVQVQCINK 128

  Fly   119 STGK--KRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQ----ALDKDAGVNGL 177
            ..|.  ...:.|:||  |.|||:|.|.:..|..||.|.||||||||....    |.|.|.|.||.
Human   129 KVGTIIYHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 191

  Fly   178 VEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTAD 242
            :||.|.....:.|:.:        ||.|.....|.:.:.|.|::|....|::.|.|:|||:|..:
Human   192 IEYVIQYNPDDPTSND--------TFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 248

  Fly   243 RLSSTTTLTVNIADSNDLDPSFIYSGCVSLDGA--CINPEYSASVP---AGSLLGVLTVLPERIQ 302
            |.::||||||::.|.:||.|.|:  .||.:...  |....|.|::|   ....|..:.|.|. ||
Human   249 RRTTTTTLTVDVLDGDDLGPMFL--PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP-IQ 310

  Fly   303 AVDLD-TINSP-----IRYSFASGMPGNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEV 361
            |:|.| .|..|     |.||...|.|.:|..:|.:...|..|...:.|:....:|:|:::|||:.
Human   311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 375

  Fly   362 SPGP-QRFTTAKLEIFVKPVDAN--PPVISSSQAEGYVDENSPIGTRVLDAHG--NPISFMTTDA 421
            :..| ..|....:||    :|.|  .|..:....:||:.|::|:|..:.|:..  :|:..:..|.
Human   376 NGHPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 436

  Fly   422 DLSDS-DPKPDYIYELTTPSFNVTGDGI--LVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAP 483
            |:.|: ||:........|..|.||..||  .:...:.:||:...  .:.|.:.|.:....  |.|
Human   437 DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ--TYTFSITAFDGVQE--SEP 497

  Fly   484 LSLTVHLRDVNDNAPKLAMVAPISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQ 548
            :.:.:.:.|.|||.|....::.......|......|.|:||.|.|||.|..:||.|. |...|
Human   498 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQG-- 559

  Fly   549 KFTINATTG--EIRTQGRLLAGEQYSITVQATD----IGGLSSQAIVEVSVTPGPNTKPPRFQKP 607
            .|.||.|||  .|.....::.|..|::||||.|    ....:|...|.:.|.|..|..||||.:.
Human   560 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 624

  Fly   608 IYEVQVSEGAEINSTVTVVHAEDPENDAVVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRY 672
            :|.:::||...:.:.:..:.|.|.|.|::.|:|.:|:..|.|.:.:.:|::.:.:.|||||..||
Human   625 MYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 689

  Fly   673 QLILKAED--TGGLSSSATVNIKVTDINDKNPEFEASTLPYVFQVEEGKAQASVGVVHATDADEG 735
            .||:.|.|  ..| :|:|||||.|||:||..|.|: ..||....|.|.:|.|.||.|.|||.|.|
Human   690 ILIITASDGRPDG-TSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKATDPDAG 752

  Fly   736 INAEITYSIPTDIPFTINATSGEILTAKELDYEQLNEYKFVVTAKDGAPDARLGTASVTVMVLDL 800
            ||.::.||:..........::|.|.||.:|:.|..:.|:.||.|.|||...|..|.::.:.|||:
Human   753 INGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 817

  Fly   801 PDEVPKFSDARIDVHIPEN-EENFLVATVQAFDPDSMPEITYVLRKGNAE-LFKVSEKSGEVRTI 863
            .|..|.|:::...|.:.|| .....:..::|.|.|....::|.:|....: .|.:...:||:..:
Human   818 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLL 882

  Fly   864 KGLDYESQKQHQLTI----------GTIENDGNGPGDTILLVVDVEDRNDLPPRF-------ITV 911
            :.||||:....:.:|          ||:.     ||...:.|: |:|.||.||.|       :..
Human   883 RSLDYEAFPDQEASITFLVEAFDIYGTMP-----PGIATVTVI-VKDMNDYPPVFSKRIYKGMVA 941

  Fly   912 PDPVTVNDDQGIGTIIATLPAIDGDGTS-PGNVVRYEI--VGRGKAPKYFQVDPDTGAVRIRDEL 973
            ||.|.       ||.|.|:.|.|.|... |.:.|||.:  |........|:|:.|:|.|..|..|
Human   942 PDAVK-------GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 999

  Fly   974 RKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFS 1038
            .:|..|.:::.:.|:|.|||.:||.|.:::.|.|     ..||.                  .|:
Human  1000 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-----PGEIP------------------RFT 1041

  Fly  1039 DDSYTTSVPESMEANSTLKLI--------QIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHG 1095
            .:.|.......:....|:..:        .||.|..||:....|          ||.|::..
Human  1042 QEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF----------GINNITGV--- 1093

  Fly  1096 CNLLLIQPLDFENKSSYSLQLRLTSHRYFVNPLK-----DTTSVEIIVQDENDNAPEFEFNRLRG 1155
              :.:..|||:|.::||.|:::..|....:..|:     :|..|.|.:||||::.|.|
Human  1094 --IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF------- 1149

  Fly  1156 QQDTFYT-VVTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDDENRVNMP-----TSFFMMSED 1214
             |..||. .|:|:..:.|::|:|:|||:|:|.:..:.|        |:.:|     ...|::...
Human  1150 -QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY--------RLIIPPIKEGKEGFVVETY 1205

  Fly  1215 TGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSHRTRARIVVNKLADINRMALSFPNAAPSDLR 1279
            ||:::||..|.|.......|.|.|.|..|:...........|||:|    .|.:...|..|:.:.
Human  1206 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL----DMQVIVSNVPPTLVE 1266

  Fly  1280 NYYTELEELLDKKT-----GLVSGIERMSSQKYLAKNGSVIENPAATDIWFYLIDPKTEQLVSRK 1339
            ....:|.|:||:..     |....:|.:.::::  .:...:|:....|:..|.|||:|.:.:.|.
Human  1267 KKIEDLTEILDRYVQEQIPGAKVVVESIGARRH--GDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1329

  Fly  1340 D--SIVETTLLE-----PAARSELNIALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLI 1397
            :  ..::..||:     .....|....|...|.|.::...:|.|.:...:.|           |:
Human  1330 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGA-----------LL 1383

  Fly  1398 AISLVILILGTIGIIYICISWSKYKNFKQRMRQYSSTNPPRYDPVI-VNQQASSASETIANMKEY 1461
            |::.:|::.....|:.:.:|   |:.||  :||...|...|....: ..:.|..|...:|
Human  1384 ALAFIIILCCIPAILVVLVS---YRQFK--VRQAECTKTARIQAALPAAKPAVPAPAPVA----- 1438

  Fly  1462 ETQMLAMAVPP------------DVDDDLQLDFSAKNHAFSLDNVSYITHKENTNGGGQSSPSHS 1514
                   |.||            ::.|.            |:.|:..:.|.:.:.|....|....
Human  1439 -------APPPPPPPPPGAHLYEELGDS------------SMHNLFLLYHFQQSRGNNSVSEDRK 1484

  Fly  1515 DATTA---TIATLRRHKNLN-NASMNNNLAINNRQNTFNRTLEMNTRNNANPLASPPNGALSGTL 1575
            .....   :..|:..||:.: :.|:.:|...:.|:.||  ..:.:..:..|||.......:|
Human  1485 HQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTF--LSDEDDLSAHNPLYKENISQVS--- 1544

  Fly  1576 TLGRIKHQNSNHYQNGAYNIDPTGPNNMAHAKNNAYSTMGRRGNTFGDVGLLNGNGELMNATLGR 1640
                   .||:..|...: :||..|...|.:|:                  |.|..|.:.....:
Human  1545 -------TNSDISQRTDF-VDPFSPKIQAKSKS------------------LRGPREKIQRLWSQ 1583

  Fly  1641 NGQLNNRLYGGEVPITNPLFQRSNSDHNHLSSTNENVSFGKRDYGQIGFSYLNDLDRSEVETTTE 1705
            :..|..||. .:||....:............:.|||........|.     .|.|..:|....||
Human  1584 SVSLPRRLM-RKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGS-----SNPLLTTEEANLTE 1642

Fly 1706 1705
Human 1643 1642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_001189311.1	Cadherin_repeat	<68..138	CDD:206637	26/79 (33%)
		Cadherin_repeat	146..259	CDD:206637	44/116 (38%)
		Cadherin_repeat	280..383	CDD:206637	33/112 (29%)
		Cadherin_repeat	393..496	CDD:206637	26/107 (24%)
		Cadherin_repeat	518..594	CDD:206637	30/81 (37%)
		Cadherin_repeat	608..699	CDD:206637	34/92 (37%)
		Cadherin_repeat	710..802	CDD:206637	35/91 (38%)
		Cadherin_repeat	814..903	CDD:206637	23/100 (23%)
		Cadherin_repeat	915..1005	CDD:206637	30/92 (33%)
		Cadherin_repeat	1041..1144	CDD:206637	27/115 (23%)
		Cadherin_repeat	1159..1264	CDD:206637	31/110 (28%)
PCDH15	NP_001136235.1	Cadherin_repeat	156..245	CDD:206637	35/96 (36%)
		Cadherin_repeat	286..394	CDD:206637	33/112 (29%)
		Cadherin_repeat	404..510	CDD:206637	26/109 (24%)
		Cadherin_repeat	518..614	CDD:206637	33/98 (34%)
		Cadherin_repeat	626..718	CDD:206637	35/92 (38%)
		Cadherin_repeat	727..820	CDD:206637	35/92 (38%)
		Cadherin_repeat	828..926	CDD:206637	23/103 (22%)
		Cadherin_repeat	935..1032	CDD:206637	32/103 (31%)
		Cadherin_repeat	1050..1145	CDD:206637	26/109 (24%)
		Cadherin_repeat	1154..1248	CDD:206637	26/101 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1431..1451		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1608..1630		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1752..1773
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1935..1962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9669
eggNOG	1	0.900	-	-		E33208_3BBMH
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23401
Inparanoid	1	1.050	442	1.000	Inparanoid score	I1661
Isobase	1	0.950	-	0	Normalized mean entropy	S7525
OMA	1	1.010	-	-		QHG47650
OrthoDB	1	1.010	-	-		D15091at33208
OrthoFinder	1	1.000	-	-		FOG0005384
OrthoInspector	1	1.000	-	-		oto90199
orthoMCL	1	0.900	-	-		OOG6_109439
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5325
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.720