DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad99C and CDH23

DIOPT Version :10

Sequence 1:NP_733314.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster
Sequence 2:NP_071407.4 Gene:CDH23 / 64072 HGNCID:13733 Length:3354 Species:Homo sapiens


Alignment Length:1995 Identity:486/1995 - (24%)
Similarity:750/1995 - (37%) Gaps:535/1995 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 LPIFGDP--DTEIALNLVFPKGQPIFQLNGKKLQ---------------------------LLQP 98
            ||.|.:.  ||.:.::...|.|..:.||..:.:.                           |.||
Human    28 LPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQP 92

  Fly    99 LDRDEENLSHIVFQVS----CTTRSTGKKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGT 159
            |||:.::...:.|.||    ..||.        :.::|.|:|||||.|.|.||.|.:||:|||||
Human    93 LDRETKSEFTVEFSVSDHQGVITRK--------VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149

  Fly   160 TIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKI 224
            .|| .:.|.|.|.|..|.|.|.....|.              .|||. ..:|.|||.:.||:|..
Human   150 PIF-IVNATDPDLGAGGSVLYSFQPPSQ--------------FFAID-SARGIVTVIRELDYETT 198

  Fly   225 QTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFIYSGCVSLDGACINPEYSASV---- 285
            |.|.||:.|:|:.:...  ||:...|.:.|.|..|:||.|            ||..||.::    
Human   199 QAYQLTVNATDQDKTRP--LSTLANLAIIITDVQDMDPIF------------INLPYSTNIYEHS 249

  Fly   286 PAGSLLGVLTVLPERIQAVDLDTINSP--IRYSFASGMPGNYADYFQIDESTGVLKQTKAVDTST 348
            |.|:.:.::|       |:|.|. ..|  |.|:..|   ||....|.:|..:|||.....:|...
Human   250 PPGTTVRIIT-------AIDQDK-GRPRGIGYTIVS---GNTNSIFALDYISGVLTLNGLLDREN 303

  Fly   349 ---AKKYDIIVKAEEV----SPGPQRFTTAKLEIFVKPVDANPPVISSSQAEGYVDENSPIG--- 403
               :..:.:.||..|:    :|.....||. ..|.|..::.|.|..:||:....:.|.:.:|   
Human   304 PLYSHGFILTVKGTELNDDRTPSDATVTTT-FNILVIDINDNAPEFNSSEYSVAITELAQVGFAL 367

  Fly   404 ---TRVLDAHGN--------------------------------------PISFMTTDA---DLS 424
               .:|:|...|                                      |:.:.|.|.   ||.
Human   368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432

  Fly   425 DSDPKPDYI-YE---------------LTTPSFNVT-------GDGILVV--------------- 451
            .::..||:: |.               .:.|.:|::       |..:|.|               
Human   433 ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY 497

  Fly   452 ------NEENLDRDPPAPG--------------RFKFQVVAREPRTNAASAPLSLTVHLRDVNDN 496
                  :..:||:|   .|              ||...::||:......:.  .:.:::.|||||
Human   498 FFSDDPDRFSLDKD---TGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDN 557

  Fly   497 APKLAMVAPI-SITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTG-EI 559
            .|.....|.: ::...:.|.::|| ::.|||.|..||..:||||...|..| ..|.|:...| .:
Human   558 VPTFQKDAYVGALRENEPSVTQLV-RLRATDEDSPPNNQITYSIVSASAFG-SYFDISLYEGYGV 620

  Fly   560 RTQGRLLAGEQYS-----ITVQATDIGG--LSSQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGA 617
            .:..|.|..||.|     :||.|.|.|.  |:|...|.:.|. ..|..||.|.||.|.|.|.|..
Human   621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVF-DENDNPPTFSKPAYFVSVVENI 684

  Fly   618 EINSTVTVVHAEDPE------NDAVVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLIL 676
            ...:||..::|.|.:      .::::||:....   ||.:...||.|.....||||:.:.|.||:
Human   685 MAGATVLFLNATDLDRSREYGQESIIYSLEGST---QFRINARSGEITTTSLLDRETKSEYILIV 746

  Fly   677 KAEDTGGLSSS-----ATVNIKVTDINDKNPEFEASTLPYVFQVEEGKAQASVGVVHATDADEGI 736
            :|.| ||:..:     |||||.:.||||.:|.::.:.. |:..||.....:.|..|.|.|.|.|.
Human   747 RAVD-GGVGHNQKTGIATVNITLLDINDNHPTWKDAPY-YINLVEMTPPDSDVTTVVAVDPDLGE 809

  Fly   737 NAEITYSI-PTDIPFTINATSGEILTAKE-LDYEQLNEY------KFVVTAKD-GAPDARLGTAS 792
            |..:.||| |.:..:::|:|:|:|.|... ||.|..:.:      |.||:..| |.|..: .|:|
Human   810 NGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLK-ATSS 873

  Fly   793 VTVMV--LDLPDEVPKFSD----ARIDVHIPENEENFLVATVQAFDPDSMPEITYVLRKGNAEL- 850
            .||.|  |||.|..|.|.:    |.:...||.....:.|..:. .|......::|.:..|...: 
Human   874 ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAID-LDEGLNGLVSYRMPVGMPRMD 937

  Fly   851 FKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGP--GDTILLVVDVEDRNDLPPRFITVPD 913
            |.::..||.|.|...||.|...::||.:  :.:|...|  ..|..|.:.|.|.||..|.|.....
Human   938 FLINSSSGVVVTTTELDRERIAEYQLRV--VASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVY 1000

  Fly   914 PVTVNDDQGIGTIIATLPAIDGDGTSPGNVVRYEIVGRGKAPKYFQVDPDTGAVRIRDELRKEED 978
            .|:|::|......:..|...|.| ......:.|.|.| |.....|.|......||....|.:|..
Human  1001 NVSVSEDVPREFRVVWLNCTDND-VGLNAELSYFITG-GNVDGKFSVGYRDAVVRTVVGLDRETT 1063

  Fly   979 TEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYT 1043
            ..|.:.:.|.|.|...........|.|..|..:.|..|                    |...||.
Human  1064 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPI--------------------FLQSSYE 1108

  Fly  1044 TSVPESM-EANSTLKLIQIVNSKTSGD----GPPAFRCEFVSGNGGGIFNLSSADHGCNLLLI-- 1101
            .||||.: |.:|.|:|     ..|..|    |...:|  .:.||.|..|.:    |..|.||:  
Human  1109 ASVPEDIPEGHSILQL-----KATDADEGEFGRVWYR--ILHGNHGNNFRI----HVSNGLLMRG 1162

  Fly  1102 -QPLDFENKSSYSLQLRLTSHRYFVNPLKDTTSVEIIVQDENDNAPEF---EFNRLRGQQDTFYT 1162
             :|||.|..||:.|.:...:|.  :.|::.:..|.:.|:|.||.||.|   :::|| |.::|   
Human  1163 PRPLDRERNSSHVLIVEAYNHD--LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRL-GLRET--- 1221

  Fly  1163 VVTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFKNE 1227
                 ..:.|:::.|:|||||||..|.|.|.:....|.:       |.:.|.||::.|..:...|
Human  1222 -----AGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-------FEIDESTGLIITVNYLDYE 1274

  Fly  1228 NDFPLTFLVEARDS-------------------DGQEQGSHRTRARIVVNKLA---DINRM-ALS 1269
            ........|.|.|.                   |...|.|:.:....::..||   :|.|: |.|
Human  1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYS 1339

  Fly  1270 FPNAAPSDLR-NYYTELEE----LLDKKTGL--VSGI---------------------------- 1299
            ..|......| |.||..:.    .:|..||:  |.|:                            
Human  1340 IDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKV 1404

  Fly  1300 ------ERMSSQKYLAKNGSVIENP---------AATDIWFYLIDPKTE---------------- 1333
                  |..:|.::...:.|.:..|         |....|    ||...                
Human  1405 YITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAW----DPDAGSNGQVVFSLASGNIAG 1465

  Fly  1334 --QLVSRKDSIVETTLLEPAARSELNIALPRATAENISFPLERKEHVHKVKAAVAIDNEVF---P 1393
              ::|:..|||.|..:..|..|.||:..:.:..|.:...|..:|:|:.:|......||...   |
Human  1466 AFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESP 1530

  Fly  1394 FTL-IAI-------SLVILILGT---IGIIYICISWSKY-----KNFKQRMRQYSSTNPPRYDPV 1442
            |.. :::       :.|:.:..|   |||..:.   |.|     |:...||.:.|.....|  |.
Human  1531 FGYNVSVNENVGGGTAVVQVRATDRDIGINSVL---SYYITEGNKDMAFRMDRISGEIATR--PA 1590

  Fly  1443 IVNQQASSASETIANMKEYETQMLAMAVP-----PDVDDDLQLDFSAKNHAFSLD------NVSY 1496
            ..:::..|....:|.:::..|..|:....     .|.:|:..: |...::...||      |.|.
Human  1591 PPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM-FQQPHYEVLLDEGPDTLNTSL 1654

  Fly  1497 ITHK-----ENTNGGGQSSPSHSDATTATIA-----TLR--RHKNLNNASMNNNLAINNRQNTFN 1549
            ||.:     |..||         ..|.|.:|     |.|  ||..:..|:...:..|::.:.|. 
Human  1655 ITIQALDLDEGPNG---------TVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTL- 1709

  Fly  1550 RTLEMNTRNNANPLASPPNGALSGTLTLGRIKHQNSN------HYQNGAYNIDPTGPNN-----M 1603
                :.|..:..|:.|  :...|.|..|..:...|.|      .|: |.:.:....|..     :
Human  1710 ----IVTATDQCPILS--HRLTSTTTVLVNVNDINDNVPTFPRDYE-GPFEVTEGQPGPRVWTFL 1767

  Fly  1604 AHAKNNAYSTMGRRGNTFGDVGLLNGNGELMNATLGRNGQLNNRLYGGE-------VPITNPLFQ 1661
            ||.:::                             |.|||:...:..|:       .|:...|..
Human  1768 AHDRDS-----------------------------GPNGQVEYSIMDGDPLGEFVISPVEGVLRV 1803

  Fly  1662 RSNSDHNHLSSTNENVSFGKRDYGQ--------IGFSYL--NDLD 1696
            |.:.:.:..:....|::...||.|.        :|...|  ||.|
Human  1804 RKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad99CNP_733314.1 CA_like 68..140 CDD:481204 22/104 (21%)
Cadherin_repeat 146..259 CDD:206637 41/112 (37%)
Cadherin_repeat 280..383 CDD:206637 28/115 (24%)
Cadherin_repeat 393..496 CDD:206637 29/207 (14%)
Cadherin_repeat 518..594 CDD:206637 30/83 (36%)
Cadherin_repeat 608..699 CDD:206637 33/101 (33%)
Cadherin_repeat 710..802 CDD:206637 36/102 (35%)
Cadherin_repeat 814..903 CDD:206637 22/91 (24%)
Cadherin_repeat 915..1005 CDD:206637 21/89 (24%)
Cadherin_repeat 1041..1144 CDD:206637 35/110 (32%)
Cadherin_repeat 1159..1264 CDD:206637 28/126 (22%)
CDH23NP_071407.4 Cadherin_repeat 42..128 CDD:206637 18/93 (19%)
Cadherin_repeat 136..231 CDD:206637 41/112 (37%)
Cadherin_repeat 240..344 CDD:206637 28/115 (24%)
Cadherin_repeat 352..456 CDD:206637 13/103 (13%)
Cadherin_repeat 465..557 CDD:206637 15/96 (16%)
Cadherin_repeat 566..667 CDD:206637 33/103 (32%)
Cadherin_repeat 676..774 CDD:206637 34/101 (34%)
Cadherin_repeat 782..886 CDD:206637 36/105 (34%)
Cadherin_repeat 894..990 CDD:206637 23/98 (23%)
Cadherin_repeat 999..1098 CDD:206637 23/100 (23%)
Cadherin_repeat 1106..1203 CDD:206637 34/109 (31%)
Cadherin_repeat 1218..1308 CDD:206637 23/104 (22%)
Cadherin_repeat 1317..1414 CDD:206637 17/96 (18%)
Cadherin_repeat 1426..1523 CDD:206637 19/100 (19%)
Cadherin_repeat 1533..1630 CDD:206637 18/101 (18%)
Cadherin_repeat 1638..1740 CDD:206637 26/117 (22%)
Cadherin_repeat 1752..1847 CDD:206637 18/123 (15%)
Cadherin_repeat 1855..1955 CDD:206637
Cadherin_repeat 1963..2065 CDD:206637
Cadherin_repeat 2075..2169 CDD:206637
Cadherin_repeat 2180..2289 CDD:206637
Cadherin_repeat 2301..2398 CDD:206637
Cadherin_repeat 2406..2504 CDD:206637
Cadherin_repeat 2513..2607 CDD:206637
Cadherin_repeat 2620..2718 CDD:206637
Cadherin_repeat 2735..2841 CDD:206637
Cadherin_repeat 2850..2951 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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