Protein Alignment Cad99C and dchs1b

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_021335025.3
• Gene: dchs1b / 553300
• ZFINID: ZDB-GENE-050208-41
• Length: 3298
• Species: Danio rerio
• Alignment Length: 1807
• Identity: 439/1807 - (24%)
• Similarity: 720/1807 - (39%)
• Gaps: 402/1807 - (22%)

  Fly    69 PDTEIALNLV--FPKGQPIFQLNGKK--LQLLQPLDRDEENLSHIVFQVSCTTRSTGKK--RTIP 127
            |::||..::.  :|....:|.|:...  |:|.:.||.:|.:...:|.|...:.....::  .::.
Zfish  1465 PNSEIRYSVQQRWPDNPDLFNLDPVTGVLKLGRELDHEETSSLFLVVQAMDSALDPNQRLWGSVT 1529

  Fly   128 IIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNV 192
            ..|.|:|.|||||.| ::|..|:|.|..|||..:. .:.|.|.|.|.||.|.|.|..|:.
Zfish  1530 ARVFVTDENDNAPIF-SSPTAVSVMEDQPVGFVLL-YVMAWDADQGENGRVSYRIQSGNT----- 1587

  Fly   193 EKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADS 257
                   .|.|.:| .:.|.:::.|.||.|:.::|.|||||.|..   ..:.|:|..|::.:.|.
Zfish  1588 -------AGRFVLS-SNSGSLSILKPLDREEQESYNLTIVAEDHG---IPQHSTTQVLSIQVIDV 1641

  Fly   258 NDLDPSF----------------------------------IYSGCVSLDGACINPE-------- 280
            ||..|.|                                  :..|.|:.||..||.|
Zfish  1642 NDEAPWFELNEFEAQIRENQPAGTSIIQVTASDRDHGTNGLVTYGGVTEDGFTINAETGVISATR 1706

  Fly   281 ---------YSASV---------------------------PAGSLLGVLTVLPERIQAVDLDTI 309
                     |:.:|                           ||..|......:||.:|.|:|.|:
Zfish  1707 VLDRELQDHYTITVYAKDGGIPPNFAKAKVHITVLDENDNAPAFGLQQYSLEVPENLQPVELFTL 1771

  Fly   310 NSP---------IRYSFASGMP-GNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPG 364
            .:.         :.|...:|.| |:    |::|.|:|.|..::.:|......|.:.|..:: ...
Zfish  1772 KATDRDIGESGRLEYKIKAGDPDGD----FRLDGSSGALSTSRPLDRERKSSYSLQVVVQD-HGS 1831

  Fly   365 PQRFTTAKLEIFVKPVDANPPVISSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDSDPK 429
            |...:||.:||.|..|:.|.|..|||.....|.|::.:|..||||       ..||.|...:...
Zfish  1832 PSLSSTASVEISVLDVNDNSPKFSSSSYTVDVSEDAAVGLVVLDA-------TATDVDEGQNGQI 1889

  Fly   430 PDYIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQVVARE-----PRTNAASAPLSLTVH 489
            ..::.:....:|.|..:...:.....|||:..|  .:.|||.|.:     ||.:.|    .:||.
Zfish  1890 LYFLSQEAKGAFTVDPNTGRITTAALLDREKRA--SYFFQVYAVDLSPAAPRNSTA----QVTVT 1948

  Fly   490 LRDVNDNAPKLAMVAP--ISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTI 552
            :.||||||| ..:..|  |::::|.....::|..:.|.|.|.|.|.    |:::.....::.|.|
Zfish  1949 ILDVNDNAP-FFIQDPLIINVSSGSVFTHQVVATMRAEDKDFGANG----SVFYRFAMPVRGFAI 2008

  Fly   553 NATTGEIRTQGRL--LAGEQYSITVQATDIGG--LSSQAIVEVSVTPGPNTKPPRFQKPIYEVQV 613
            |:.||.|:|...|  |...|.::.|:|.|.|.  .||..:|.:.|.. .:.|..||.:...:|.:
Zfish  2009 NSLTGAIQTTENLQTLTQTQRTLIVEAMDQGSPPQSSLGVVIIYVKE-QDYKGIRFSRTARDVSL 2072

  Fly   614 SEGAEINSTVTVVHAEDPE--NDAVVYSIISGNDLRQFAVGQESGVIIV--IRKLDRESLTRYQL 674
            .|.|:..:.|....|:.|:  .|.:.|||.|||....|::...:|.|.|  ...||.|...|.:|
Zfish  2073 QENADKGTVVAQAQAQHPDGTRDGINYSIFSGNKYHSFSISSNTGEIWVQSSNGLDFEDTPRLRL 2137

  Fly   675 ILKAEDTGGLSSSATVNIKVTDINDKNPEFEASTLPYVFQVEEGKA-QASVGVVHATDADEGINA 738
            ::|||.|.. ||...||:.:.|:||..|.|:...  ||..:.|.:. ...:..|.|.|.|:|.|.
Zfish  2138 VVKAETTSS-SSFMAVNLILQDVNDNRPRFQLQN--YVTYMHEAQGYDFPIIQVVAEDVDQGQNG 2199

  Fly   739 EITYSIPTDIP---FTINATSGEILTAKELDYEQLNEYKFVVTAKDGAPDARLGTASVTVMVLDL 800
            ::||:|.:...   |.|:..:|.|.|...:|.|...:.|.|:.|.|......:|||::||:::||
Zfish  2200 QVTYTIESSNQSGLFKIDPQTGIITTTAIMDREIWTQAKLVIKATDRGSPKLVGTATITVIIVDL 2264

  Fly   801 PDEVPKFSDARIDVHIPENEENFLVAT----VQAFDPDSMPEITYVLR-----KGNAELFKVSEK 856
            .|..|.....| :|.:|||.   |:.|    |...|.||.|.::|.|:     :|.   |.:...
Zfish  2265 NDNSPTIPVPR-EVRVPENS---LIGTEITLVTGNDVDSGPVLSYSLQLDASTQGK---FDIDRY 2322

  Fly   857 SGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTILLVVDVEDRNDLPPRFITVPDPVTVNDDQ 921
            :|.|.....||||.:..::|||..  :|.....:..|.|| |||.||..|.|......||:.:..
Zfish  2323 NGRVSLTAPLDYEERTWYKLTIRA--SDSKHQSEANLTVV-VEDVNDNVPTFTQDLYQVTLPEHS 2384

  Fly   922 GIGTIIATLPAIDGDGTSPGNVVRYEIVGRGKAPKYFQVDPDTGAVRIRDELRKE-EDTEYQVDI 985
            ..|:.:.|:.|.|.|....|. |.|.::...:  ..|.|||..|.|.||.:.:.: |:....:.|
Zfish  2385 PPGSPVITVTATDRDSGENGK-VSYRVLSSTR--DGFYVDPKNGTVFIRQKAKFDPEEPSVSIVI 2446

  Fly   986 RAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTSVPESM 1050
            .|.|.|.|.|||.|.::|.    |...|:...:.::||                  |..:|.|..
Zfish  2447 EARDGGSPPLSSSATVQVQ----LMDVNDNAPIFHQLE------------------YKATVSEDQ 2489

  Fly  1051 EANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSA-----DHGC----NLLLIQPLDF 1106
            ...:|:..::.|:...|.:. ..|.....|||.|..|.:.|:     .||.    .|:|.:.|||
Zfish  2490 LPGATILTLEAVDGDLSQEN-SGFDFAIASGNVGNAFQIESSVRFIEGHGFQTVGTLILAERLDF 2553

  Fly  1107 ENKSSYSLQLRLTSHRYFVNPLKDTTSVEII-VQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDV 1170
            |..|.|:|.:.::....   |.:.::...|| |.|.|||.|.|      |:.: :...::|....
Zfish  2554 EALSHYNLTVSVSDRGV---PQRSSSVPAIITVTDVNDNPPVF------GRAE-YIVALSEGAAA 2608

  Fly  1171 DTTILQVRATDRDSGKFGTVRYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFL 1235
            ...||:|.|||.||..:..|:|::...|:.::      |.:.:.||.::..:....|:......:
Zfish  2609 GAEILRVTATDPDSAPYAEVQYSISSGDDMKL------FSVDQWTGAMKLQRPLDRESQNSHVVI 2667

  Fly  1236 VEARDSDGQEQGSHRTRARIVVNKLADINRMALSFP--------------NAAPSDLR------N 1280
            |:|.|..|      |.....:..::.|||.....||              |:|.:.|.      .
Zfish  2668 VQASDGHG------RFALAPISVEVKDINDNRPYFPIATLTASIRENQPLNSAVTVLHAIDYDTG 2726

  Fly  1281 YYTELEELL-------------DKKTGLVS-----GIERMSSQKYLAKNGSVIENPAATDIWFYL 1327
            .|.:|:..|             |:.:|.|.     ..|:::|..::|.......|.|...:..::
Zfish  2727 VYGQLKYYLMDHSSPGKDLFFVDQNSGEVRTKQIFDFEKVNSFNFIALAVDAGNNSATVTVQVFI 2791

  Fly  1328 I-DPKTEQLVSRKDSIVETTLLEPAARSELNIALPRATAEN--------ISFP------------ 1371
            . :.:.:.:.:..|...|   :...|:...:|.|.:|..|:        .|||
Zfish  2792 TGEDEYDPVFTTSDLSFE---VPEGAKKGQSIGLVQAKDEDGGVDGIVLYSFPNSSPYFDVNKTT 2853

  Fly  1372 ---------------------------LERKEH-------VHKVKAAVAIDNEVF----PFTLIA 1398
                                       ::...|       |...:..:.:.|..|    .|.::.
Zfish  2854 GVIYLKMDNSGSSSGGSRSKRETRLMTMDVSAHSPLDTSRVASAQVIIDVTNTSFGLATDFNILL 2918

  Fly  1399 ISLVILILGTIGIIYICISWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASETIANMKEYET 1463
            :|::...||.| ::.:.|:.:.|....:|.::.....         |..|||.:         ..
Zfish  2919 VSIIAASLGVI-VLLVIIAVALYLVRSKRKKKGQDAG---------NSTASSGT---------AL 2964

  Fly  1464 QMLAMAVPPDVDDDLQLDFSAKNHAFSLDNVSYITHKENTNG-----GGQSSPSHSDAT-TATIA 1522
            |.|..:.|           |..:..:......|...:|.|..     ||...||||... :|..|
Zfish  2965 QKLDESKP-----------SGSDRIYHQALPGYAGDEEGTGAGSYTRGGSLDPSHSSGRGSAEAA 3018

  Fly  1523 TLRRHKNLNNASMNNNLAINNRQNTFNRTLEMNTRNNANPLAS---PP----------------- 1567
            .....:.:|......::..:.:::...|..:...:.:|:.|:.   .|
Zfish  3019 EDDEIRMINEYPRVASITSSMQEHISARGPDSGIQQDADQLSDISCEPGPLDASQWFKSKKLGSI 3083

  Fly  1568 NGALSGTLTLGRIKHQNSNHYQNGAYNIDPTGPN---NMAHAKNNAYSTMGR 1616
            :|:|||||..|::.....   :.|.|    .|..   |::|.|:.|:...|:
Zfish  3084 SGSLSGTLLSGQLPVYRD---EGGGY----LGVGRGLNISHPKDYAFPEDGK 3128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	19/76 (25%)
		Cadherin_repeat	146..259	CDD:206637	36/112 (32%)
		Cadherin_repeat	280..383	CDD:206637	31/156 (20%)
		Cadherin_repeat	393..496	CDD:206637	28/107 (26%)
		Cadherin_repeat	518..594	CDD:206637	24/79 (30%)
		Cadherin_repeat	608..699	CDD:206637	31/94 (33%)
		Cadherin_repeat	710..802	CDD:206637	30/95 (32%)
		Cadherin_repeat	814..903	CDD:206637	31/97 (32%)
		Cadherin_repeat	915..1005	CDD:206637	29/90 (32%)
		Cadherin_repeat	1041..1144	CDD:206637	30/112 (27%)
		Cadherin_repeat	1159..1264	CDD:206637	22/104 (21%)
dchs1b	XP_021335025.3	None