DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad99C and pcdh15b

DIOPT Version :9

Sequence 1:NP_001189311.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster
Sequence 2:XP_009304712.1 Gene:pcdh15b / 503521 ZFINID:ZDB-GENE-050214-1 Length:1964 Species:Danio rerio


Alignment Length:1891 Identity:513/1891 - (27%)
Similarity:810/1891 - (42%) Gaps:407/1891 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAARNSLTPQQGLGFFGLLILLCSAVLGKSQMCEVE------TGQTNIILDIEESRESFIGQPTT 59
            |..|:.|....|:| .|:|:|..::....|:..:.|      ||....|:.|:|.         :
Zfish     3 MRQRSWLYKWLGIG-IGVLLLTAASYSQDSEDWQYEECKLSRTGPPATIVAIDEQ---------S 57

  Fly    60 P------PELPIFG---DPDTEIALNL---------VFPKGQPIFQLNGKKLQLLQPLDRDEEN- 105
            |      ..:.|.|   |||..|:|:|         :.|..|.:: ||...    :.||||..: 
Zfish    58 PNGTLLVENMQINGRAEDPDRTISLSLRDNNDYWVILDPVKQRLY-LNSTG----RVLDRDPPSY 117

  Fly   106 LSHIVFQVSCTTRSTGKKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFR----NIQ 166
            :..||.||.||....|......:.:.|.|.|||||||....|.|.|.|.||||||||.    |..
Zfish   118 IQSIVVQVQCTNELVGTVILHEVRIVVRDRNDNAPRFQQPRYYVAVNELTPVGTTIFSGFTGNNG 182

  Fly   167 ALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTI 231
            |:|.|.|.||.:||.| :.:|......:       ||.|.....|.|.:.:.|::|:|..|.:.|
Zfish   183 AVDIDDGPNGQIEYTI-QYNPRDPTTNR-------TFDIPLTLSGSVVLRERLNYEEITRYLVII 239

  Fly   232 VASDRARNTADRLSSTTTLTVNIADSNDLDPSFIYSGCVSLDGACINPEYSASV-----PAGSLL 291
            .|:|||.|..|||::||||||::.|.:||.|.|:....|.....|....|.||:     |  |.:
Zfish   240 QANDRAPNPKDRLTATTTLTVDVLDGDDLGPMFLPCSLVDNTRDCKPLTYRASILELTDP--SRV 302

  Fly   292 GVLTVLPERIQAVDLD-TINSP-----IRYSFASGMPGNYADYFQIDESTGVLKQTKAVDTSTAK 350
            ..:.|.|. |||||.| .|..|     |.||...|.|..|.::|.::.||..|:..||:.....:
Zfish   303 NPVNVTPP-IQAVDQDRNIQPPSDRPGILYSILIGKPETYGEFFWMNRSTAELQLLKAISREKYQ 366

  Fly   351 KYDIIVKAEEVSPGP-QRFTTAKLEIFVKPVDAN--PPVISSSQAEGYVDENSPIGTRVLDAH-- 410
            .:|:::|||:.:..| ..|....:|:    :|.|  .|....:...|::.|::|:||.:..:.  
Zfish   367 HFDLVIKAEQDNGHPLPAFANLHIEV----LDENNQAPYFQVATYHGFISESAPLGTTISSSANL 427

  Fly   411 GNPISFMTTDADLSDS-DPKPDYIYELTTPSFNVTGDGIL--------VVNEENLDRDPPAPGRF 466
            ..|::.:..|.|:.:: ||......:.....|.||..||:        |.:||.     |.   :
Zfish   428 STPLAIIVLDNDIEETKDPMVRISLDNYNGIFAVTAGGIVRYLTLLRPVDHEEQ-----PT---Y 484

  Fly   467 KFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLAMVA-PISITAGDQSESRLVTQVTATDNDEG 530
            .|.::|.:....  |||:::.:.:.|.|||.|....|: .:|:.. |......|.|:||.|.|:|
Zfish   485 AFTMIASDGVQE--SAPVTINITVIDANDNTPTFPNVSYGVSVYT-DMQPGDPVLQLTALDADDG 546

  Fly   531 PNAVVTYSIYHVSNNGIQKFTINATTGEIRT--QGRLLAGEQYSITVQATDIGGL----SSQAIV 589
            ||.:|:|.|. ..:.|  .||||..||.|..  ...|..|..|::||:|||.|..    ||...|
Zfish   547 PNGLVSYKIL-AGDQG--HFTINDCTGVITVLPSVNLTVGRSYALTVRATDNGPTAQRRSSITTV 608

  Fly   590 EVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPENDAVVYSIISGNDLRQFAVGQE 654
            .:.|.|..|..||||.:.:|.:::||.....:|:..:.|.|.|.|.:.|||..|:....|.|.|.
Zfish   609 YIEVLPPNNQSPPRFHQLVYSLEISEAMRTGATLLNIQATDREKDPITYSIQKGDPNNVFEVSQT 673

  Fly   655 SGVIIVIRKLDRESLTRYQLILKAED--TGGLSSSATVNIKVTDINDKNPEFEASTLPYVFQVEE 717
            ||::::.:.||||....|.|.:.|.|  ..| :|:.||||.|||:||.:|||: ..||....|:|
Zfish   674 SGLLLLAKTLDREITDHYTLTVTASDGKPDG-TSTTTVNIAVTDVNDNDPEFD-PLLPLNLTVQE 736

  Fly   718 GKAQASVGVVHATDADEGINAEITYSIPT--DIPFTINATSGEILTAKELDYEQLNEYKFVVTAK 780
            .:|.|.||.|.|||.|.|||.::.|.:.:  |: |.| :.:|.|.||..||.|:..:|..:|.|.
Zfish   737 EEANAFVGQVKATDLDLGINGQVRYRLVSYPDL-FRI-SPNGSIFTAMPLDREERAQYDLIVQAS 799

  Fly   781 DGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENEE-NFLVATVQAFDPDSMPEITYVLR 844
            |||.|.|..|.::::.|||:.|..|.||.......:|||.. ..::..:.|.|||....:||.:|
Zfish   800 DGAKDPRRTTITLSITVLDVDDNSPVFSPPAYHATLPENSPVGTVILNISALDPDLDANVTYRIR 864

  Fly   845 KGNA-ELFKVSEKSGEVRTIKGLDYESQKQHQLT----IGTIE-NDGNGPGDTILLVVDVEDRND 903
            ...| |||.|:..:||::.::.||:|....:..|    :..:: ..|..|.....:.|.|.|.||
Zfish   865 TKEARELFAVNSLTGELKVLRSLDFEKLLPNATTQTFVVEALDGGSGKMPPGLASVTVTVLDMND 929

  Fly   904 LPPRF-------ITVPDPVTVNDDQGIGTIIATLPA--IDGDGTSPGNV-VRYEIVGRGKAPKYF 958
            .||.|       :..|:.|.       |||:..:.|  :|..||:...| .:.::.....:...|
Zfish   930 FPPVFSQTLYRGMVAPNAVK-------GTIVTAVHAEDLDPPGTAASRVHYKADLEQFPYSTSIF 987

  Fly   959 QVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLE 1023
            .|:.::|.:..|..|.:|.:|::.:.:.|||.|||...:.:.:.:.|..|               
Zfish   988 DVEENSGNIFTRVNLNEEPNTKFSLAVIAYDDGEPMKFNKSLVEITVLQL--------------- 1037

  Fly  1024 SGTGMSSESIGLAFSDDSYTTSVPESMEA--------------NSTLKLIQIVNSKTSGDGPPAF 1074
                    ||...|:.:.|..: |.|..|              |.|: :..|:.....|      
Zfish  1038 --------SIIPVFTQEEYRFA-PVSENAPVGTVAGVILAAAINQTI-VYSIIEGNEGG------ 1086

  Fly  1075 RCEFVSGNGGGIFNLSSADHGCNLLLIQPLDFENKSSYSLQLRLTSHRYFVNPLK-----DTTSV 1134
              |||..|..|:  :|:|         :|||:|:.|||.|::...|.|...:.|:     :|..|
Zfish  1087 --EFVVNNNTGV--ISTA---------KPLDYESNSSYVLRVEADSMRVVSSNLRAPAKSNTAKV 1138

  Fly  1135 EIIVQDENDNAPEFEFNRLRGQQDTFYT-VVTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDD 1198
            .|.||||||:.|.|        ...||. .|.|:....|::|||:|.|:|:|.:..:.|.|    
Zfish  1139 FIDVQDENDHPPVF--------TKPFYLGGVAEDAKTFTSVLQVQALDKDTGNYSAMLYRL---- 1191

  Fly  1199 ENRVNMPTS----FFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSHRTRARIVVNK 1259
               :..||:    .|::...|||::||..::|.......|.|.|.|:.|:...|   .|::||:.
Zfish  1192 ---IIPPTTDGKDGFVIEPFTGVIKTAIMYRNMRRSYFKFDVVATDNYGEGLSS---SAQVVVSV 1250

  Fly  1260 LADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVSG------------IERMSSQKYLAKNG 1312
            :..:: |.:...|..|       |.:|:..|:..|::..            :|.:.::::  .:|
Zfish  1251 VNQLD-MQVVVSNVPP-------TVVEQNKDRLIGILERYVQDQIPGAKVVMESIGARRF--GDG 1305

  Fly  1313 SVIENPAATDIWFYLIDPKTEQLVSRKD--SIVETTLLEPAARSE---------LNIALPRATAE 1366
            ...|:...:|:..|.|||.|.:.:||::  ..::..||:.....:         |.|..| ...|
Zfish  1306 YEQEDYTKSDLMVYAIDPLTNRALSRQELFKFLDGKLLDINKEFQPYLGRGGRILEIRTP-DVVE 1369

  Fly  1367 NISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYICISWSKYKNFKQRMRQY 1431
            :::      ..||.|.....        .|:|::::|::.....|:.:.|:   |:.||:|    
Zfish  1370 SVT------RAVHSVGYTEG--------ALLALAVIIILCCIPAILIVIIT---YRQFKER---- 1413

  Fly  1432 SSTNPPRYDPVIVNQQASSASETIANMKEYETQMLAMAVPPDVDDDLQLDFSAKNHAFSLDNVSY 1496
                           ||..|          :|..:.||:|           :.|:...:.:|:..
Zfish  1414 ---------------QAECA----------KTARIQMALP-----------TGKSGGAATNNLYE 1442

  Fly  1497 ITHKENTNGGGQSSPSHSDATTATIATLRRHKNLNNASMNNNLAINNRQN-------TFNRTLEM 1554
            ........|.|     |.:.......:|.|.:.|:..|     .|:..|:       .:....::
Zfish  1443 ELGDSTMRGYG-----HQEQQQLLRPSLLRPEELSMES-----GIDPGQDYYTQDYYNYEHGYDL 1497

  Fly  1555 NTRNNANPLASPPNGALSGTL-TLGRIKHQNSNHYQNGAYNIDPTGPNNMAHAKNNAYSTMGRR- 1617
            ....:...|.||     ||.. ..|.:..::     :|:|...|       |......:..||| 
Zfish  1498 PQYGSRRKLISP-----SGMYDEYGEVIMED-----DGSYYYSP-------HESEGEVARQGRRL 1545

  Fly  1618 ----GN---------TFGDV--------GLLNGNGELMNATLG-----RNGQL-------NNRLY 1649
                |.         .|||:        |:.:......:..||     |:...       |||::
Zfish  1546 AQHPGKAPPPNLPKLAFGDLPPRLGAADGITHPYSSKASTKLGQMFDRRSAPAPFHLPWKNNRIF 1610

  Fly  1650 GGEVPITNP-------------LFQRSNSDHNHL------SSTNENVSFGKRDYGQIGFSYLNDL 1695
                ||..|             ..|.|||..|.:      ..|.|.::..|...|:: .|.:|.|
Zfish  1611 ----PIVGPEQKEGSTDDFKPTRMQHSNSVDNGVFIDGSYFQTKEALTSAKTRLGKV-LSQMNIL 1670

  Fly  1696 DRSEVE 1701
            ...:.:
Zfish  1671 KTMQTQ 1676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad99CNP_001189311.1 Cadherin_repeat <68..138 CDD:206637 24/79 (30%)
Cadherin_repeat 146..259 CDD:206637 48/116 (41%)
Cadherin_repeat 280..383 CDD:206637 35/114 (31%)
Cadherin_repeat 393..496 CDD:206637 26/113 (23%)
Cadherin_repeat 518..594 CDD:206637 32/81 (40%)
Cadherin_repeat 608..699 CDD:206637 34/92 (37%)
Cadherin_repeat 710..802 CDD:206637 38/93 (41%)
Cadherin_repeat 814..903 CDD:206637 26/95 (27%)
Cadherin_repeat 915..1005 CDD:206637 22/92 (24%)
Cadherin_repeat 1041..1144 CDD:206637 34/121 (28%)
Cadherin_repeat 1159..1264 CDD:206637 32/109 (29%)
pcdh15bXP_009304712.1 Cadherin_repeat 159..267 CDD:206637 48/115 (42%)
Cadherin_repeat 288..396 CDD:206637 35/114 (31%)
Cadherin_repeat 406..512 CDD:206637 26/115 (23%)
Cadherin_repeat 520..616 CDD:206637 36/99 (36%)
Cadherin_repeat 627..720 CDD:206637 35/93 (38%)
Cadherin_repeat 729..822 CDD:206637 38/94 (40%)
Cadherin_repeat 831..929 CDD:206637 26/97 (27%)
Cadherin_repeat 939..1035 CDD:206637 23/102 (23%)
Cadherin_repeat 1047..1148 CDD:206637 34/121 (28%)
Cadherin_repeat 1161..1240 CDD:206637 26/85 (31%)
NESP55 <1784..1894 CDD:115071
SRRM_C 1846..>1893 CDD:291883
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 70 1.000 Domainoid score I9512
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H23401
Inparanoid 1 1.050 467 1.000 Inparanoid score I1503
OMA 1 1.010 - - QHG47650
OrthoDB 1 1.010 - - D15091at33208
OrthoFinder 1 1.000 - - FOG0005384
OrthoInspector 1 1.000 - - otm25355
orthoMCL 1 0.900 - - OOG6_109439
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.880

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