Protein Alignment Cad99C and Cad89D

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Alignment Length: 2298
• Identity: 462/2298 - (20%)
• Similarity: 716/2298 - (31%)
• Gaps: 943/2298 - (41%)

  Fly    99 LDRD-EENLSHIVFQVSCTTRSTGKKRT------IPIIVRVSDINDNAPRFMNTPYEVTVPESTP 156
            :||| ..||  :.|::.|    .||:..      :.|.|.:.|:|||||.|:|.||.|.|.|:|.
  Fly   135 VDRDVPRNL--LKFRILC----AGKQEKLEEGSYLSITVYIEDVNDNAPEFLNVPYVVDVDENTS 193

  Fly   157 VGTTIFRNIQALDKDAGVNGLVEYFIAEGSPN-------STNVEKYSADGYGTFAISFPHQGQVT 214
            :.:.||..:||.|:|           ...:||       ||..|:.||||...||:..||:..:.
  Fly   194 IESIIFEGVQAFDRD-----------KPNTPNSEVHFSMSTVPEQLSADGSPYFALKSPHRPLLI 247

  Fly   215 VAKTLDFEK-IQTYYLTIVASDRA--RNTADRLSSTTTLTVNIADSNDLDPSF---IYSGCVSLD 273
            :.:.|||:. |:.:.|.|.|.||.  .|.|:     ||:|:|:.|.:||.|.|   :|.
  Fly   248 LKRELDFDNGIRQFKLPIFAWDRGTPANQAN-----TTITINVRDVDDLPPKFTEGVYR------ 301

  Fly   274 GACINPEYSASVPAGSLLGVLTVLP----ERIQAVDLDTINSPIRYSFASGMPGNYADYFQIDES 334
             ..||..|       .:.||...:|    ..|.|.|.|::|:.:.|...|   ||....|:::..
  Fly   302 -TRINEFY-------PMTGVPIRIPLYFAPPIMAFDQDSLNASLVYDIIS---GNERQLFRVNPH 355

  Fly   335 TGVLKQTKAVDTSTAKKYDIIVKAEEVSPG--------------PQRFTTAKLEIFVKPVDANPP 385
            .||:...|.:|..           ||..||              |.:...|::|:.|..::.|.|
  Fly   356 NGVMYLQKEIDLE-----------EESLPGNTFVLQLEARQKDNPLKKALARIEVEVLDLNDNVP 409

  Fly   386 VISSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDSDPKPDYIYELT------------- 437
            ...:......:.||.|.|..||..:       ..|.|..::.   :::|.|.
  Fly   410 EFEADYYNISIVENLPTGFSVLQVN-------AVDRDQGENS---EFLYNLVETKDAAGAFRIDS 464

  Fly   438 -TPSFNVTGDGIL--------VVNEENLDRDP--------PAPGRFKFQVVAREPRTNAASAPLS 485
             |....|..|.:|        .:|.|.|:|:|        ..||..|.||
  Fly   465 RTGWITVRDDRLLDREQRRSIQLNVEALERNPSYLDDKHLKKPGPSKVQV--------------- 514

  Fly   486 LTVHLRDVNDNAPKL------AMVAPISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSN 544
             .:.|.|.|||.||.      ....||:...|     .::.||.|.|.|||||..:.|.:.....
  Fly   515 -EITLLDTNDNTPKFEHGNLYEFKVPINAPTG-----YVIGQVVAHDPDEGPNGHLLYELQRPKG 573

  Fly   545 NGIQKFTINATTGEIRTQGRLLAGEQYSITVQATDIGGLSSQ-----AIVEVSV----------- 593
            :|...|.::...|.|...|.|..| :.::.|:|||.....|:     |::.:.|
  Fly   574 SGYIPFRLDNKNGTIYVGGPLRRG-RIAVFVEATDQPTNPSERRFSLAVITIEVYATIDDQAIDF 637

  Fly   594 --TP-----GPNT------------------------------------------------KPPR 603
              .|     |.||                                                :...
  Fly   638 VGAPYEFWVGANTPLGTSVGQVRTTLIYEGGDEIMYDLLHTYSEGVPFAIEERSGIITVIRELSE 702

  Fly   604 FQKPIYEVQV--------------------------------SEGA------------------- 617
            |::.:|:.:.                                .||.
  Fly   703 FKRKVYQFEAVANYLFANSSQSLVMSRSSSPLTTIASPAELSDEGVLITNLTIHIVNKPEQKVPL 767

  Fly   618 -----EINSTVTVVHAEDPENDAVVYSIISGNDL-------------------RQFAVGQ----- 653
                 |||..|...|.|:.....::..::..|.:                   |...:|.
  Fly   768 RPVIEEINMNVIHFHVEENVVGGIIGQLLYKNGINLVNNELGTYREMPSEPTSRNITMGSRFRSR 832

  Fly   654 -----------------------------------------ESGVIIVIRKLDRESLTRYQLILK 677
                                                     |.|.::.:..||||....|:|.:.
  Fly   833 NRSRSSKSKRRLPRRLVGDANIKLRYIIANQQEVVNKISITEDGTLLTLTGLDREQQPSYELTVI 897

  Fly   678 AEDTGGLSSSA---TVNIKVTDINDKNPEFEASTLPYVFQVEEG-KAQASVGVVHA---TDADEG 735
            .|.:.||.|.|   .|||||.|:||..|:|.|  |.||..:.|. .....:.:.||   .|||||
  Fly   898 VEYSTGLVSGAGIYQVNIKVDDVNDNAPKFNA--LTYVGLINENCVVGTELSMNHAILIQDADEG 960

  Fly   736 INAEI------TYSIPTDIPFTINATSGEILT--------------------AKELDYEQLNE-- 772
            .|||.      .||....|.: :|.||.|..|                    ..|..|::|:.
  Fly   961 PNAEFRVQLQGDYSDEFSIEY-VNGTSSENSTHHKMPSTTGAFNIFNLTDQWNDEFKYQELHTTF 1024

  Fly   773 ------------YKFVVTAKDG--------------APD--ARLGTASVTVMVLDLPDEVPK--- 806
                        ::...|.|.|              |.|  ...|.|.:||:|.|:.|..|.
  Fly  1025 MQTNFKLSSGPYFRISYTGKRGLDREKQQLYNLKIIAADTGGLSGYAHLTVLVADVNDNAPMFER 1089

  Fly   807 ---FSDARIDV----------------------------------HIPENE-------------- 820
               |.|:|:::                                  |||.:.
  Fly  1090 ISVFKDSRLEIREYTTDMEIYFVESSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGAGL 1154

  Fly   821 --------------------------ENFLVAT----VQAFDPD--------------------S 835
                                      |:..|.|    :.|.|.|                    .
  Fly  1155 GVVARAKSRRRMVRALTTKCPLFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQGEQVERTPG 1219

  Fly   836 MPEITYVLRKGNAELFKVSEKSGE------------------VRTIKGL---------------- 866
            ||    :||....:.|.:.:.|||                  |..|.||
  Fly  1220 MP----MLRVHGVKYFAIDKLSGELSVNYPLSANIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNH 1280

  Fly   867 ----------------DYESQKQHQLTIGTIENDGNG----------------PGDTILLV---- 895
                            :|:.....|||...::...|.                |...:|.:
  Fly  1281 APTFKKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSHLPFTIKPASGVLKIGGQL 1345

  Fly   896 ---------------------------VDVE----DRNDLPPRFITVPDPV-------TVND--- 919
                                       ||||    |.||..|.||...|..       :|.|
  Fly  1346 DRELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEFIGYDDQTKAVKFIPSVADRTL 1410

  Fly   920 ---------DQGI--GTIIATLPAIDGDGTSPGN-VVRYEIVGRGKAPKYFQVDPDTGAVRIRDE 972
                     |:..  ||.:..|.|||.|....|| :|.|.|..:......||:|...|.:.....
  Fly  1411 MLPVYKAYLDRSTQPGTFVRQLTAIDKDNVGNGNGLVLYSIRHQEMQAPLFQIDSRDGTISTISR 1475

  Fly   973 LRKEEDTEY-QVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLA 1036
            :....|.|: .|.:.|.|:|.|.||:.|.:.|::.                           |.|
  Fly  1476 INGYNDYEHLNVSVIASDVGSPALSATAIVIVNLQ---------------------------GQA 1513

  Fly  1037 FSDDSYTTSVPESMEANST--------LKL-------IQIVN-SKTSGDGPPAFRCEFVSGNGGG 1085
            .:|...:|..||. .||.|        :||       |:::. :.::|..|..:|.......|
  Fly  1514 VTDPPKSTPKPEP-PANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEEG-- 1575

  Fly  1086 IFNLSSAD-------HGCNLLL--IQPLDFENKSSYSLQLR-------LTSHRYFVNPLKD---- 1130
               |...|       ...|:||  ::|.|.|:.|.|.|::|       ..::.....|:.|
  Fly  1576 ---LDETDAHPPFEYDAKNMLLYALKPFDREHISRYQLRIRADRLSREARNYARVSYPVVDERIE 1637

  Fly  1131 -----TTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGKFGTV 1190
                 ...:.:.:.|||||||:|     ||.......|:.:.......:.:|.|.|.|.|....:
  Fly  1638 GLSLNECRILVHIADENDNAPKF-----RGNGQPIVAVLPQSASFGYPVTRVEANDLDEGLNAEI 1697

  Fly  1191 RYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSHRTRARI 1255
            ||.|       :|.|...|.:.|.:|.:|..... :..:....|.|:|.|..|.:.|    |:.|
  Fly  1698 RYRL-------LNEPARLFGIDELSGNIRLLGEL-SRTEHIYGFDVKATDRMGADDG----RSGI 1750

  Fly  1256 V------VNKLADINRMALSFP---------------NAAPSDLRNYYTELEELLDKKTGLVSGI 1299
            |      :|:...:..:....|               :|...|:|      ..||:..:|   |:
  Fly  1751 VNVFVYIINEAKQVRLVVAGMPVEVERRIEGLMEALSDAIGKDVR------VRLLEPYSG---GL 1806

  Fly  1300 ERMSSQKYLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKDSIVETTLLEPA-ARSELNI----- 1358
            |                  .||:.:.|.:||.|       :||:|...|:.| |..:|:.
  Fly  1807 E------------------PATNAYIYAVDPHT-------NSIMEMEQLQDALAGLQLDALQLQQ 1846

  Fly  1359 -------ALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGII---- 1412
                   .:||.        ||..|.....:.|.|..:. |...|..:::|:|.|.::|.:
  Fly  1847 QKLDGGKPMPRI--------LELAEFGQLARPAHASASS-FMGGLEFVTVVLLALISLGALIAAC 1902

  Fly  1413 -YICISWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASE-----TIANMKEYETQMLAMAVP 1471
             |:|:        :|:.|.:|             |:..|||:     |||.:.....|.
  Fly  1903 CYVCM--------RQKRRLWS-------------QRDFSASDAGLTYTIAGIGSPRGQK------ 1940

  Fly  1472 PDVDDDLQLDFSAKNHAFSLDNVSYITHKENTNGGGQSSP-----------SHSDATTATIATLR 1525
                   |.....:.|          |.:.:....|...|           |....:||| ||.:
  Fly  1941 -------QRRQRQQRH----------TQRCSKGSTGSQRPTSAFMPESVCSSAQTQSTAT-ATEK 1987

  Fly  1526 RHKNLNNASMNNNLAINNRQNTFNRTLEMNTRNNANPLASPPNGALSGTLTLGR----------- 1579
            ..:.|::......:|...:.:.:....:...:.....:..|.:.|.:..:|.|.
  Fly  1988 LEQQLHHHHQQQAMATQQQHHQYLNEQQRQQKREYIDVPLPKSIAKAAAVTSGGDGAVGVGSTPF 2052

  Fly  1580 -IKH------QNSNHYQNGAYNIDPTGPNNMAH--AKNNAYSTM--------GRRGNTFGDVGLL 1627
             :|:      .|.|:|:...:::..||.::...  :....|.|.        .:|||
  Fly  2053 VLKYNACQPVNNLNNYETSLFSLHSTGQDSGVEFLSSRELYETSPDSFQHGGSKRGN-------- 2109

  Fly  1628 NGNGELM-------NATLGRNGQLNNRLYGGEVPITNPL--------------FQRSNSDHNHLS 1671
              |.|::       :..|.:....::..|...:....||              .|:..|.|.|.
  Fly  2110 --NTEVLCPRHAKAHLELRQPNTDSSDTYEDSLKTDEPLVAHNCRSANCEHRQHQQHPSHHPHY- 2171

  Fly  1672 STNENVSFGKRDYGQIGFSYLND 1694
               :|..|.||...:..||.:.|
  Fly  2172 ---QNTRFEKRSCVRHSFSGVKD 2191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	15/47 (32%)
		Cadherin_repeat	146..259	CDD:206637	41/122 (34%)
		Cadherin_repeat	280..383	CDD:206637	26/120 (22%)
		Cadherin_repeat	393..496	CDD:206637	27/132 (20%)
		Cadherin_repeat	518..594	CDD:206637	24/93 (26%)
		Cadherin_repeat	608..699	CDD:206637	31/214 (14%)
		Cadherin_repeat	710..802	CDD:206637	35/151 (23%)
		Cadherin_repeat	814..903	CDD:206637	33/287 (11%)
		Cadherin_repeat	915..1005	CDD:206637	30/112 (27%)
		Cadherin_repeat	1041..1144	CDD:206637	30/143 (21%)
		Cadherin_repeat	1159..1264	CDD:206637	25/110 (23%)
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	41/122 (34%)
		Cadherin_repeat	325..407	CDD:206637	22/95 (23%)
		Cadherin_repeat	416..524	CDD:206637	27/133 (20%)
		Cadherin_repeat	534..626	CDD:206637	26/97 (27%)
		Cadherin_repeat	641..>714	CDD:206637	6/72 (8%)
		CA	851..925	CDD:214520	21/73 (29%)
		CA	1026..1085	CDD:214520	12/58 (21%)
		Cadherin_repeat	1177..1280	CDD:206637	18/106 (17%)
		Cadherin_repeat	1289..1385	CDD:206637	13/95 (14%)
		Cadherin_repeat	1414..1510	CDD:206637	28/95 (29%)
		CA	1576..1658	CDD:214520	19/81 (23%)
		Cadherin_repeat	1666..1760	CDD:206637	24/105 (23%)