DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad99C and cdh23

DIOPT Version :10

Sequence 1:NP_733314.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster
Sequence 2:NP_999974.1 Gene:cdh23 / 407978 ZFINID:ZDB-GENE-040513-7 Length:3366 Species:Danio rerio


Alignment Length:1890 Identity:467/1890 - (24%)
Similarity:736/1890 - (38%) Gaps:511/1890 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 DTEIA-----LNLVFPKGQP-IFQLNGKK-------------LQLLQPLDRDEENLSHIVFQVSC 115
            ||.:.     |..|.|.|:| ||.:.|::             :.|.|||||:.::...:.|.|| 
Zfish    51 DTPVGTSITQLQAVDPDGEPLIFGVVGEEAMRYFAVQGTTGVVWLRQPLDREAKSEMQVEFTVS- 114

  Fly   116 TTRSTG-KKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVE 179
              .|.| .|.|:.|  ::.|:|||||.|.|.||.:.:||:|||||::|. :.|.|.|.||.|.|.
Zfish   115 --DSQGVVKDTVNI--QIGDVNDNAPSFYNQPYAIQIPENTPVGTSVFM-VNATDPDQGVGGSVL 174

  Fly   180 YFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRL 244
            :.....|      :.:|.||         .:|.|||.:.||:|....|.||:.|:|:.:...  |
Zfish   175 FSFQPPS------QFFSIDG---------ARGIVTVTRALDYETTIAYQLTVNATDQDKRRP--L 222

  Fly   245 SSTTTLTVNIADSNDLDPSFIYSGCVSLDGACINPEYSASV----PAGSLLGVLTVLPERIQAVD 305
            ||...|.:.|.|..|:||.|            .|..||.::    |.|..:       .:|:|:|
Zfish   223 SSLANLAITITDIQDMDPIF------------TNLPYSTNIMEDAPPGYEV-------RKIRAID 268

  Fly   306 LDTINSP--IRYSFASGMPGNYADYFQIDESTGVLKQTKAVDTST---AKKYDIIVKAEEV---- 361
            .| :..|  |.|:..|   ||....|.:|..:|.|..:..:|...   :..:.|.|||.|:    
Zfish   269 QD-LGRPRGIGYTIIS---GNTNSMFALDYISGSLTVSGQLDRENPLYSSGFIITVKATELNDDR 329

  Fly   362 SPGPQRFTTAKLEIFVKPVDANPPVISSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDS 426
            :|.....||....:.:...| |||..:||:....:.|.:.:|..:      |:.....|.|    
Zfish   330 TPSSATVTTTFTILLIDKND-NPPRFNSSEYRVLITELAQVGFAL------PLYIQVEDKD---- 383

  Fly   427 DPKPDYIYELTTPSFNV--TGDGILVVNEENLDRDPPA-PGR------------------FKFQV 470
                    |.....|.|  ||:     |.::....|.: .||                  :.|.:
Zfish   384 --------EGVNSMFQVFLTGN-----NSDHFSISPTSVQGRADLRLRVAIPLDYETIRSYSFSL 435

  Fly   471 VAREPRTNAASAPLSLTVH---------LRDVNDNAPKLAMV-----APISITAGDQSESRLVTQ 521
            .|.|          ||:.|         |.:.|||.|..:..     .|.||..|..     :.|
Zfish   436 YANE----------SLSEHVGFARVFIDLINENDNRPIFSQTLYNISLPESIEPGAS-----LLQ 485

  Fly   522 VTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTGEIRTQGRL--LAGEQYSITVQATDIGGLS 584
            :.|||||.|...||.   |:.|:...| |:::|.||.:..:|||  ....::::|:.|.|.||..
Zfish   486 IKATDNDIGTFGVVR---YYFSDEPDQ-FSLDAETGWVTLRGRLDYELMRRFTLTILARDGGGEE 546

  Fly   585 SQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAED---PENDAVVYSIISGNDL 646
            :...:.::|. ..|...|.|||..|...:.|..:....|....|.|   |.|:.:.||||..:..
Zfish   547 TTGRLRINVM-DVNDNAPVFQKEAYTGSLMENEQAPQQVIRARATDEDSPPNNILTYSIIYASQF 610

  Fly   647 RQF---AVGQESGVIIVIRKLDRESLT--RYQLILKAEDTG--GLSSSATVNIKVTDINDKNPEF 704
            |.|   ::.:...||.|.|.||.|.:.  ...|.|.|:|.|  .|:|:..|.|::.|.||..|||
Zfish   611 RSFFSISIAEGYAVITVTRPLDYEQVPGGLIFLTLMAKDGGNPSLNSTVPVIIELIDQNDNPPEF 675

  Fly   705 EASTLP-YVFQVEEG-KAQASVGVVHATDAD---EGINAEITYSIPTDIPFTINATSGEILTAKE 764
               :|| |:..:.|. .|.|:|..|:|||.|   |.....:.||:.....|.:|..||||.|...
Zfish   676 ---SLPSYIVNIPENIVAGATVLFVNATDLDASREFGQTSLIYSLQGSSQFRLNTRSGEITTTAL 737

  Fly   765 LDYEQLNEYKFVVTAKDG--APDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPE-NEENFLVA 826
            ||.|..:||..:|.|.||  .|..:.|.|:|.:.|||:.|..|.:.|.....::.| :..:..|.
Zfish   738 LDREMKSEYILIVRAVDGGVGPQQKTGIATVNITVLDINDNAPVWRDEPYQANVVEMSPIDTDVI 802

  Fly   827 TVQAFDPD--SMPEITYVLRKGNAELFKVSEKSGEVRTIKG-LDYESQ--KQHQL--TIGTIEND 884
            ||.|.|||  ....:.|.:...| ..:.::..:|::||... ||.|||  :..||  ||.....|
Zfish   803 TVFAVDPDYGDNGTVVYSINPEN-PFYTINRNTGKIRTSGAVLDRESQDARSAQLMRTIIISATD 866

  Fly   885 GNGP----GDTILLVVDVEDRNDLPPRFITVPDPVTVNDDQGIGTIIATLPAIDGDGTSPGNVVR 945
            ...|    ..:..:.|::.|.||..|.|:.:|....|.:...||:.:..:...|.|..:.|.|..
Zfish   867 RGTPPLRSSASATVFVNLLDLNDNDPAFLNLPFVAEVPEGLPIGSSVFRVQVQDPDEAANGAVTM 931

  Fly   946 YEIVGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGE------------------ 992
            ...:|..:..  |:::..||.:.....|.:|:..:|.:.|.|||.|:                  
Zfish   932 ALQMGMPRLD--FRLNITTGILVSTVVLDREQIGQYYLRIIAYDAGQFPRTSTSTLTITVLDVND 994

  Fly   993 ------PQLSSV---------------------APLRVDVHHLLSSGNNEIKLDNKLESG--TGM 1028
                  |.:.:|                     |.|..::.:.:::||.    |.|...|  ||:
Zfish   995 ETPTFFPSVYNVSLEESVPRDYLVVRLNCTDNDAGLNAELSYFITAGNQ----DGKFSVGFRTGV 1055

  Fly  1029 SSESIGL------------------------------------------AFSDDSYTTSVPESME 1051
            ....:||                                          .|..:||.|||.|::.
Zfish  1056 VRTVVGLDRETQASYRLVIEAIDNGPAGGRRTGTATVYVEVLDVNDNRPIFLQNSYETSVLENIP 1120

  Fly  1052 ANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNGG--------GIFNLSSADHGCNLLLIQPLDFEN 1108
            ..:::..:|..::....:|...:|  .:|||.|        |:.:..|.          .||.|.
Zfish  1121 RGTSILQVQATDADQGENGKVLYR--ILSGNNGQFSMDSLSGLISRGSV----------ALDRET 1173

  Fly  1109 KSSYSLQLRLTSHRYFVNPLKDTTSVEIIVQDENDNAPEF---EFNRLRGQQDTFYTVVTEEMDV 1170
            :||..|::.  ::...:..::.|..|.:.|:|.||..|.|   ::||| |.::|        ..:
Zfish  1174 RSSNVLEVE--AYNSDLGSMRSTVRVIVYVEDVNDEFPVFTQSQYNRL-GLRET--------AGI 1227

  Fly  1171 DTTILQVRATDRDSGKFGTVRYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFL 1235
            .|:::.|||||.|:|..|.|.|:|....:.:       |.:...||:|.|..:...|........
Zfish  1228 GTSVVVVRATDPDTGDGGAVAYSLVSGSDRK-------FEVDVSTGLLTTVDYLDYETKTSYLMN 1285

  Fly  1236 VEARDSDGQEQGSHRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVSGIE 1300
            |.|.|   |....||:...:.|..|.:::. |::|.:|      .|...|.|      .:.:|.|
Zfish  1286 VSATD---QSPPFHRSYCTVYVTLLNELDE-AVAFLSA------GYEVSLRE------NIATGTE 1334

  Fly  1301 RMSSQKYLAKNGSVIE-------NPAATDIWFYLIDPKTEQLV-------SRKDSIVETTLLEPA 1351
            .:..:...|.|.:.:.       :|||  :..:.||..|.::.       .|.||...|.:.:..
Zfish  1335 VVQVKAQSADNLNQLSYRFDPDTSPAA--LALFKIDSVTGRITVTGLLDRERGDSYTLTVVADDG 1397

  Fly  1352 A-------------------------RSELNIALPRATA--ENISFPLERKEHVHKVKAAVAIDN 1389
            .                         .|:|::.:|..||  :.::..|.|.:...:        |
Zfish  1398 GPKRGSTVKVSITILDENDNSPEFDITSDLSVNIPEDTAIGKRVAVVLARDKDAGR--------N 1454

  Fly  1390 EVFPFTLIA-----ISLVILILGTIGIIYI--CISWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQ 1447
            .:..|||||     :..:..:..|.|.:|:  .:.......:..::|...:.:||||..|     
Zfish  1455 GLVNFTLIAGNMQDVFKINTVNNTYGEVYLNAPLDRESVDRYLLKVRAMDNGSPPRYTDV----- 1514

  Fly  1448 ASSASETIANMKEYETQMLAMAVPPDVDDDLQLDFSAKNHAFSLDNVSYITHKENTNGGGQSSPS 1512
              |.:..|.                ||:|:..:..|.:.:     |||.   .||..||      
Zfish  1515 --SLTVNIV----------------DVNDNPPVLQSPRGY-----NVSV---SENVGGG------ 1547

  Fly  1513 HSDATTATIATLRRHKNLN-NASMNNNLAINNRQNTF---NRTLEMNTRNNANPLASPPNGAL-- 1571
                 |:.:..:...:::. ||.::..:...|:..||   ..|.|:.||      .|||:...  
Zfish  1548 -----TSVLRVVATDRDIGANAMLSYYITAGNQDLTFRMDRMTGEIVTR------PSPPDREKQQ 1601

  Fly  1572 ----------SGTLTLG-------RIKHQNSNHYQNGAYNIDPTGPNNMAHAKNNAYSTMGRRG- 1618
                      .||.||.       ||..:|.|         .|..|       ...|.|..|.| 
Zfish  1602 QYTLTVTVEDDGTPTLSTSTTVWVRIIDENDN---------APEFP-------EEEYVTELREGP 1650

  Fly  1619 NTFG-----------DVGLLNGNGELMNA----TLGRNGQLNNRLYGGEVPITNPLFQRSNSDHN 1668
            ||.|           |.||   ||.:..|    .|.:..|:|:  ..|::.:.:.|....::.|.
Zfish  1651 NTVGAIIATVTAIDPDEGL---NGTIRYAISKGNLAQTFQINS--VTGQIVVVSALDYEISNGHY 1710

  Fly  1669 HLSST 1673
            .|:.|
Zfish  1711 VLTVT 1715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad99CNP_733314.1 CA_like 68..140 CDD:481204 28/89 (31%)
Cadherin_repeat 146..259 CDD:206637 39/112 (35%)
Cadherin_repeat 280..383 CDD:206637 28/115 (24%)
Cadherin_repeat 393..496 CDD:206637 22/132 (17%)
Cadherin_repeat 518..594 CDD:206637 24/77 (31%)
Cadherin_repeat 608..699 CDD:206637 30/100 (30%)
Cadherin_repeat 710..802 CDD:206637 37/98 (38%)
Cadherin_repeat 814..903 CDD:206637 26/100 (26%)
Cadherin_repeat 915..1005 CDD:206637 23/134 (17%)
Cadherin_repeat 1041..1144 CDD:206637 26/110 (24%)
Cadherin_repeat 1159..1264 CDD:206637 27/104 (26%)
cdh23NP_999974.1 Cadherin_repeat 48..134 CDD:206637 26/87 (30%)
Cadherin_repeat 142..237 CDD:206637 39/112 (35%)
Cadherin_repeat 246..350 CDD:206637 28/115 (24%)
Cadherin_repeat 358..460 CDD:206637 22/134 (16%)
Cadherin_repeat 469..561 CDD:206637 30/101 (30%)
Cadherin_repeat 570..671 CDD:206637 31/100 (31%)
Cadherin_repeat 679..778 CDD:206637 36/98 (37%)
Cadherin_repeat 786..890 CDD:206637 27/104 (26%)
Cadherin_repeat 898..994 CDD:206637 20/97 (21%)
Cadherin_repeat 1003..1102 CDD:206637 12/102 (12%)
Cadherin_repeat 1110..1206 CDD:206637 25/109 (23%)
Cadherin_repeat 1221..1311 CDD:206637 27/107 (25%)
Cadherin_repeat 1321..1417 CDD:206637 17/103 (17%)
Cadherin_repeat 1428..1526 CDD:206637 24/128 (19%)
Cadherin_repeat 1536..1633 CDD:206637 27/121 (22%)
Cadherin_repeat 1641..1743 CDD:206637 21/80 (26%)
Cadherin_repeat 1755..1850 CDD:206637
Cadherin_repeat 1858..1958 CDD:206637
Cadherin_repeat 1966..2068 CDD:206637
Cadherin_repeat 2076..2172 CDD:206637
Cadherin_repeat 2181..2292 CDD:206637
Cadherin_repeat 2304..2401 CDD:206637
Cadherin_repeat 2410..2507 CDD:206637
Cadherin_repeat 2516..2610 CDD:206637
Cadherin_repeat 2624..2722 CDD:206637
Cadherin_repeat 2738..2849 CDD:206637
Cadherin_repeat 2858..2959 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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