DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad99C and pcdh15a

DIOPT Version :9

Sequence 1:	NP_001189311.1	Gene:	Cad99C / 43528	FlyBaseID:	FBgn0039709	Length:	1706	Species:	Drosophila melanogaster
Sequence 2:	XP_009305800.1	Gene:	pcdh15a / 368476	ZFINID:	ZDB-GENE-030616-3	Length:	1806	Species:	Danio rerio

Alignment Length:	1509	Identity:	437/1509 - (28%)
Similarity:	693/1509 - (45%)	Gaps:	247/1509 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EESRESFIGQPTT----PPELP----------IFG---DPDTEIALNL---------VFPKGQPI 85
            ||.:.|..|.|.|    ..|.|          |.|   |||..|:|.|         :.|..|.:
Zfish    35 EECKLSRSGPPATIVTIDEESPNGTILVENMQINGRARDPDRTISLTLLDNYDYWVILDPALQRL 99

  Fly    86 FQLNGKKLQLLQPLDRD-EENLSHIVFQVSCTTRSTGKKRTIPIIVRVSDINDNAPRFMNTPYEV 149
            | ||...    :.|||| ..:::.||.|:.||....|......:.:.|.|.|||.|||....|.|
Zfish   100 F-LNSTG----RVLDRDPPSSITTIVVQIQCTNELVGTVILHEVRIVVRDRNDNTPRFQQPRYYV 159

  Fly   150 TVPESTPVGTTIFR----NIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQ 210
            :|.|.||||||||.    |..|.|.|.|.||.:||.| :.:||.....:       |..|:....
Zfish   160 SVNELTPVGTTIFTGFSGNNGATDIDDGPNGQIEYAI-QYNPNDPMSNR-------TVRIAGTLS 216

  Fly   211 GQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFIYSGCVSLDGA 275
            |.:.:|:.|::|:...|.:.:.|:|||.....|.::|||||:::.|.:||.|.|:  .||.::..
Zfish   217 GNIVLAERLNYEERTRYLIIVQANDRAPYPGTRRTATTTLTLDVLDGDDLGPMFL--PCVLVNNT 279

  Fly   276 --CINPEYSASVPA---GSLLGVLTVLPERIQAVDLD-TINSP-----IRYSFASGMPGNYADYF 329
              |....|..::|.   .:.|..|.|.|. |:|:|.| .|..|     |.|....|.|..|.::|
Zfish   280 QDCNPVTYRVAIPELTDPNKLNPLNVTPP-IRAIDQDRNIQPPSDRPGILYFILVGTPSTYPEFF 343

  Fly   330 QIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDANPPVISSSQAEG 394
            .::.||..|:..|:||....:::.:::|||:.:..|.. ..:||||.:...:...|....|...|
Zfish   344 TLNRSTAELRLLKSVDRELYQRFSLVIKAEQDNGHPLP-AYSKLEIEILDENNQAPYFQQSSYRG 407

  Fly   395 YVDENSPIGTRVLDAHGN---PISFMTTDADLSDS-DPKPDYIYELTTPSFNVTGDGILVVNEEN 455
            :|.|:|.:|| .:.|..|   |::.:..|.|:.:: ||:........|..|.:|..||.
Zfish   408 FVSESSSVGT-TISASANLTAPLAIIALDNDIEETKDPQLKITLNEYTSIFTITTSGIT------ 465

  Fly   456 LDRDPPAPGRF--KFQVVAREPRTN-----------AASAPLSLTVHLRDVNDNAPKLAMVAPIS 507
                     ||  ..:.|.||.:||           ..|.|:::.:.:.|.|||.|..|.|:...
Zfish   466 ---------RFLTLLKPVDREIQTNYTLTLVATDGVQQSRPVTVDILVIDANDNTPTFAQVSYSV 521

  Fly   508 ITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTGEIR-TQGRLL-AGEQ 570
            ....:......|.|:.|.|.|.|.|.::||:|. ..::|  .|.||..||.|. ..|.:| .|..
Zfish   522 EIFTNMLPGETVLQLMAQDADAGLNGLITYAIL-AGDHG--DFIINNRTGRITLAPGVMLTVGRS 583

  Fly   571 YSITVQAT----DIGGLSSQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDP 631
            |::||:|.    |....||...|.:.|.|..|..||||....|.:::||...|.:.:..:.|.|.
Zfish   584 YALTVRAADNAPDTERRSSITTVYIEVLPPNNQSPPRFPLQTYNLEISEAMRIGAILLNLQATDR 648

  Fly   632 ENDAVVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLILKAED--TGGLSSSATVNIKV 694
            |.|.:.|.|.:|:....|.:.:..|::::.:.||||::.:|:||:.|.|  .||: |:|||:|.:
Zfish   649 ELDPITYRIETGDPQEVFNLSRTIGLLLLAKPLDRETIDQYRLIVTASDGHPGGI-STATVSIVI 712

  Fly   695 TDINDKNPEFEASTLPYVFQVEEGKAQASVGVVHATDADEGINAEITYSIPTDIP-FTINATSGE 758
            ||:||.:|.|:. |||....|.|.:|...||.|.|||.|.|:|.::.|.:.:... |:||:| |.
Zfish   713 TDVNDNDPTFDL-TLPRNLTVREEEANVFVGQVRATDPDGGLNGQVRYRLLSFASLFSINST-GS 775

  Fly   759 ILTAKELDYEQLNEYKFVVTAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPEN-EEN 822
            |.||..||.|..:.|..:|.|.|||.|.|..|.::.|.|||:.|..|.||.....|::||| ...
Zfish   776 IFTAVPLDRETRSRYDLIVEASDGAVDPRRTTITLLVEVLDINDNSPVFSQPVYTVNVPENTPAG 840

  Fly   823 FLVATVQAFDPDSMPEITYVLRKGNA-ELFKVSEKSGEVRTIKGLDYES----QKQHQLTIGTIE 882
            .::..:.|.|.|.:..:||.::...| :||.|:..:|.:..::.||:||    ...:...:..::
Zfish   841 SIILRLTAVDADLVSNVTYRIKTEAALQLFAVNRLTGVISVLQALDFESLAAGNSTYTFEVEALD 905

  Fly   883 NDGNGPGDTILLVVDVEDRNDLPPRFITVPDPVTVNDDQGIGTIIATLPAIDGD--GTSPGNVVR 945
            :.|..|..|..:.|.:.|.||..|.|........|..:...||:|.|:.|.|.|  || |.:.||
Zfish   906 HGGVLPPGTATVSVRITDMNDFSPVFRQALYKGLVAPNAEKGTVITTVLAEDQDPPGT-PASKVR 969

  Fly   946 YEIVGRGKAP---KYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEP--------QLSSVA 999
            |. |.:..:|   ..|.|:.|||.|..:..|.::..|.:::.:.|||.|||        :::.:.
Zfish   970 YR-VDQELSPYSGSIFDVETDTGLVITKVNLNEQPTTVFKLVVMAYDDGEPVKTNRTTVEITVLQ 1033

  Fly  1000 PLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTS-VPESMEANSTLKLIQIVN 1063
            |.|:.:                               |:::.|..| |.|:....:.:.||....
Zfish  1034 PSRIPI-------------------------------FTEEEYRFSPVSENAPIGTPVGLILAAA 1067

  Fly  1064 SKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLIQPLDFENKSSYSLQLRLTSHRYFVNPL 1128
            :.|:      .....||||.||:|.::.:. |. :...:.||:||.:||.|:::..|....:..|
Zfish  1068 TNTT------VVYSIVSGNEGGVFTVNKST-GI-IYTNKSLDYENVTSYVLRVQADSLTVILANL 1124

  Fly  1129 K-----DTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGKFG 1188
            :     :|..|.|.||||||:.|.|       .:..:...|||:....||:|::.|||.|:|.:.
Zfish  1125 RAPSKTNTAKVFINVQDENDHPPVF-------SRQVYIGGVTEDTKTFTTVLKIVATDVDTGNYS 1182

  Fly  1189 TVRYTLYDDDENRVNMPTS----FFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSH 1249
            .:.|.|       :..||:    .|::...|||:::|..|:|.......|.|.|.|..|:...|
Zfish  1183 KMAYRL-------IIPPTTEGQDSFVIEPYTGVIKSAIMFRNMRRSYFKFQVVATDDYGKGLTS- 1239

  Fly  1250 RTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVSGIER-----MSSQKYLA 1309
              :|.:||:.:..:: |.:...|..|       |.:||   .|..|:|.:||     :...|.:.
Zfish  1240 --KADVVVSVVNALD-MQVVVSNVPP-------TVVEE---NKEQLISILERYVQDQIPGAKVIV 1291

  Fly  1310 KN--------GSVIENPAATDIWFYLIDPKTEQLVSRKD--SIVETTLLEPAARSE--------- 1355
            ::        |..:|:.:.:|:..|.|||.|.:.:||::  ..::..:|:.....:
Zfish  1292 ESIGPRRHGEGYELEDYSKSDLQVYAIDPLTNRAISRQELFKFLDGKILDINKEFQPYLGEGGRI 1356

  Fly  1356 LNIALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYICISWSK 1420
            |.|..|...|.           |.|...||.....    .|:|::::|::.....|:.:.::
Zfish  1357 LEIRSPDIVAT-----------VKKAAQAVGYTEG----ALLALAIIIILCCIPAILIVMVT--- 1403

  Fly  1421 YKNFKQRMRQYSST 1434
            ||.||:|..:.:.|
Zfish  1404 YKQFKERQAECAKT 1417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_001189311.1	Cadherin_repeat	<68..138	CDD:206637	24/79 (30%)
		Cadherin_repeat	146..259	CDD:206637	42/116 (36%)
		Cadherin_repeat	280..383	CDD:206637	32/111 (29%)
		Cadherin_repeat	393..496	CDD:206637	29/119 (24%)
		Cadherin_repeat	518..594	CDD:206637	28/81 (35%)
		Cadherin_repeat	608..699	CDD:206637	31/92 (34%)
		Cadherin_repeat	710..802	CDD:206637	38/92 (41%)
		Cadherin_repeat	814..903	CDD:206637	23/94 (24%)
		Cadherin_repeat	915..1005	CDD:206637	32/102 (31%)
		Cadherin_repeat	1041..1144	CDD:206637	32/108 (30%)
		Cadherin_repeat	1159..1264	CDD:206637	31/108 (29%)
pcdh15a	XP_009305800.1	Cadherin_repeat	49..148	CDD:206637	28/103 (27%)
		Cadherin_repeat	157..246	CDD:206637	35/96 (36%)
		Cadherin_repeat	286..394	CDD:206637	32/109 (29%)
		Cadherin_repeat	404..510	CDD:206637	29/121 (24%)
		Cadherin_repeat	518..614	CDD:206637	30/98 (31%)
		Cadherin_repeat	625..718	CDD:206637	32/93 (34%)
		Cadherin_repeat	727..820	CDD:206637	38/93 (41%)
		Cadherin_repeat	828..926	CDD:206637	23/97 (24%)
		Cadherin_repeat	936..1032	CDD:206637	30/97 (31%)
		Cadherin_repeat	1044..1145	CDD:206637	32/108 (30%)
		Cadherin_repeat	1153..1252	CDD:206637	31/108 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23401
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1503
OMA	1	1.010	-	-		QHG47650
OrthoDB	1	1.010	-	-		D15091at33208
OrthoFinder	1	1.000	-	-		FOG0005384
OrthoInspector	1	1.000	-	-		otm25355
orthoMCL	1	0.900	-	-		OOG6_109439
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.880