DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad99C and ds

DIOPT Version :9

Sequence 1:NP_001189311.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster
Sequence 2:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster


Alignment Length:1870 Identity:434/1870 - (23%)
Similarity:712/1870 - (38%) Gaps:450/1870 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 SHI------VFQVSCTTRSTG---KKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIF 162
            |||      |.|::...|..|   ...|..::|.:.|:|||.|.|..:.|.|:|.|:.|||..|.
  Fly   567 SHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRCIL 631

  Fly   163 RNIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTY 227
            : :.|.|.|.|||.:|.|.|.||..:.|..|..||            .|::.:|..||||:..:|
  Fly   632 K-VSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSA------------SGEICIAGELDFERRSSY 683

  Fly   228 YLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFI---YSGCVSLDGACINPEYSASVPAGS 289
            ...::|:||.     .||:|..:.:.:.|.||..|.|.   |.  |||..   :|:.|:...:..
  Fly   684 EFPVLATDRG-----GLSTTAMIKMQLTDVNDNRPVFYPREYK--VSLRE---SPKASSQASSTP 738

  Fly   290 LLGVLTVLPERIQAVDLDTIN-SPIRYSFASGMPGNYADYFQIDESTG----VLKQTKAVDTSTA 349
            ::.|:        |.|.|..| ..:.|...:   ||.|..|:||.|||    |.....:|.|...
  Fly   739 IVAVV--------ATDPDYGNFGQVSYRIVA---GNEAGIFRIDRSTGEIFVVRPDMLSVRTQPM 792

  Fly   350 KKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDA--NPPVISSSQAEGYVDENSPIGTRVLD---- 408
            ...:|     ..:.|....:.|...:|:..:||  .||:...::...||.|:.|.||.|..    
  Fly   793 HMLNI-----SATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAA 852

  Fly   409 ----AHGNPISFMTTDADLSDSDPKPDYIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQ 469
                ||.:|:.:.....|       ||..:.:.|.|.|:.       ..:.||.:..:......|
  Fly   853 SGDVAHRSPVRYSIYSGD-------PDGYFSIETNSGNIR-------IAKPLDHEAKSQVLLNIQ 903

  Fly   470 VVAREPRTNAASAPLSLTVHLRDVNDNAPKL-AMVAPISITAGDQSESRLVTQVTATDNDEGPNA 533
            ....||.....:   .:.:.:.|||||||:. |.:..||:....:..:.|.. ..|.|.|.|.:.
  Fly   904 ATLGEPPVYGHT---QVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYA-AHAHDKDSGSSG 964

  Fly   534 VVTYSIYHVSNNGIQKFTINATTGEIRTQGRL--LAGEQYSITVQATDIG--GLSSQAIVEVSVT 594
            .||||:...|..|:  |.|:|.:|.:.....|  .:.:::::.|.|||.|  .||:...:.|.| 
  Fly   965 QVTYSLVKESGKGL--FAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDV- 1026

  Fly   595 PGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPE---NDAVVYSI-----------ISGND 645
            ...|..||.|:|..|.|.|||...||:.:..|:|.|.:   |..:.|.|           ||.:|
  Fly  1027 QDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSD 1091

  Fly   646 LRQ-FAVGQESGVIIVIRKLDRESLTRYQLILKAEDTGGLSSSA--TVNIKVTDINDKNPEFEAS 707
            :.| |.:...||.|.:...||||:..||||.:.|.|.|..::.|  .|.::|.|.||.:|:|:.|
  Fly  1092 VSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKS 1156

  Fly   708 TLPYVFQVEEGKAQAS-VGVVHATDADEGINAEITYS-IPTDIPFTINATSGEILTAKELDYEQL 770
              .|.|::||...:.| ||||.|:|.|.|.||.|.|| :|.:..|.::..:|||.|.:.||.|..
  Fly  1157 --KYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSSFQVHPVTGEISTREPLDRELR 1219

  Fly   771 NEYKFVVTAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENEE--NFLVATVQAFDP 833
            ..|..||.|:|.....|.....|.:.|.|:.|..|:.:|.:.||.....|:  ...|..|:|.|.
  Fly  1220 ELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDR 1284

  Fly   834 D--SMPEITYVLRKGNAE----LFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTI 892
            |  ....|||.:.||...    ||.:...||.:||...||:|.:..::|.:.. .:.||.|.:|:
  Fly  1285 DHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAA-SDGGNPPRETV 1348

  Fly   893 -LLVVDVEDRNDLPPRFITVPDPVTVNDDQGIGTIIATLPAIDGDGTSPGNVVRYEI-------- 948
             :|.|:|.|.||..|.|.:......|.:|..:|.::.::..|:    .|.:|||..:        
  Fly  1349 RMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIE----RPADVVRNSVEESFEDLR 1409

  Fly   949 -------VGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDL---GEPQLSSV----- 998
                   :.:......|.:|..:|.:.:...|.:|..:|::::|||.|.   ..||.|::     
  Fly  1410 VTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIE 1474

  Fly   999 -----------------------APLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDD 1040
                                   .|:...:|:..::           ::.||.:.:   |.:...
  Fly  1475 VADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTAT-----------DADTGTNGD---LQYRLI 1525

  Fly  1041 SYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLIQPLD 1105
            .|...:.||.|...:|                 ||.:.::|               .|.|..|||
  Fly  1526 RYFPQLNESQEQAMSL-----------------FRMDSLTG---------------ALSLQAPLD 1558

  Fly  1106 FENKSSYSLQLR-LTSHRYFVNPLKDTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMD 1169
            ||....|.|.:: |.........|:.:.:|.:.:.|.||:||.|......|.: |....:::...
  Fly  1559 FEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGK-TASLFISDATR 1622

  Fly  1170 VDTTILQVRATDRDSGKFGTVRYTLY-DDDENRVNMPTSFFMMSEDTGVLRTAKHFKN-----EN 1228
            :...:..:.|.|.|||..|.:.|.:. .:.|.|       |.::..||::...|....     |.
  Fly  1623 IGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGR-------FRINSQTGIIELVKSLPPATEDVEK 1680

  Fly  1229 DFPLTFLVEARDSDGQE------------QGSHRT---------RARIVVN-------------K 1259
            ......::.|:|....|            ||||..         ||.|:.|             .
  Fly  1681 GGRFNLIIGAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKS 1745

  Fly  1260 LADINRMALSF--PNAAPSDLRNYYTELEELLDKKTGLVS---GIERMSSQKYL----------- 1308
            |.......||:  |....:||.:        :|.:.|:::   ..:|.|...|:           
  Fly  1746 LHGAENANLSYEIPAGVANDLFH--------VDWQRGIITTRGQFDRESQASYVLPVYVRDANRQ 1802

  Fly  1309 -AKNGSVIENPAATD---------------IWFYLIDPKTEQLVSRKDS-------------IVE 1344
             ..:.|.:....::|               |:..:.|........|..|             ::.
  Fly  1803 STLSSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENSEPGVIH 1867

  Fly  1345 TTL---LEPAARSEL-----------NIALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFT 1395
            |.:   |:....::|           ..::..::.|..:.||:|::|........|.|.......
  Fly  1868 TVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELSARPLDREQHSRYTLQIQASDRGQPKSR 1932

  Fly  1396 LIAISLVILILGTIGIIYICISWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASETIANMKE 1460
            ....::.|.:                        :..:.|.||:       :.|..:.::.....
  Fly  1933 QGHCNITIFV------------------------EDQNDNAPRF-------KLSKYTGSVQEDAP 1966

  Fly  1461 YETQMLAM-AVPPDVDDDLQLDFSAKNHA---FSLDNVSYITHKENTNGGGQSSPSHSDATTATI 1521
            ..|.::.: ||..|:..:.:|.:|..|..   |::|..|.:.    |..|.......:......:
  Fly  1967 LGTSVVQISAVDADLGVNARLVYSLANETQWQFAIDGQSGLI----TTVGKLDRELQASYNFMVL 2027

  Fly  1522 ATLRRHKNLNNASMN---NNLAINNRQNTFNR---------------TL---------------- 1552
            ||......:.:|::.   |.|.||:.:..|.|               ||                
  Fly  2028 ATDGGRYEVRSATVPVQINVLDINDNRPIFERYPYIGQVPALIQPGQTLLKVQALDADLGANAEI 2092

  Fly  1553 --EMNTRNNANPL---ASPPNGALSGTLTL----GRIKH------QNSNHYQNGAYNID------ 1596
              .:|..|:|...   .:|..||||.:.:|    |::.|      ...|..|:....|:      
  Fly  2093 VYSLNAENSAVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQSSLGLIELLIGEA 2157

  Fly  1597 PTGPNNMAHAKNNAYSTMGRRGNTFG----DVGLLNGNGELMNATL-----GRNGQLNNRLYGGE 1652
            |.| ..:...:|..|..|.:..:..|    .|..|..:|.......     ..:|.|:.....||
  Fly  2158 PQG-TPVLRFQNETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQFSFGAGNEDGILSLDSLSGE 2221

  Fly  1653 VPITNPLFQRSNSDHNHLSSTNEN-VSFGKRDYGQIGFSYLNDLDRSEVE 1701
            :.:..|..    .|::..|:.:.: :|.|:      ...|..::|.|..|
  Fly  2222 IRVNKPHL----LDYDRFSTPSMSALSRGR------ALHYEEEIDESSEE 2261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad99CNP_001189311.1 Cadherin_repeat <68..138 CDD:206637 11/39 (28%)
Cadherin_repeat 146..259 CDD:206637 37/112 (33%)
Cadherin_repeat 280..383 CDD:206637 25/109 (23%)
Cadherin_repeat 393..496 CDD:206637 24/110 (22%)
Cadherin_repeat 518..594 CDD:206637 24/79 (30%)
Cadherin_repeat 608..699 CDD:206637 36/107 (34%)
Cadherin_repeat 710..802 CDD:206637 36/93 (39%)
Cadherin_repeat 814..903 CDD:206637 30/97 (31%)
Cadherin_repeat 915..1005 CDD:206637 22/135 (16%)
Cadherin_repeat 1041..1144 CDD:206637 22/103 (21%)
Cadherin_repeat 1159..1264 CDD:206637 27/144 (19%)
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637
Cadherin_repeat 509..607 CDD:206637 11/39 (28%)
Cadherin_repeat 616..711 CDD:206637 38/112 (34%)
Cadherin_repeat 719..820 CDD:206637 28/121 (23%)
Cadherin_repeat 832..927 CDD:206637 24/111 (22%)
Cadherin_repeat 937..1032 CDD:206637 28/98 (29%)
Cadherin_repeat 1040..1149 CDD:206637 37/108 (34%)
Cadherin_repeat 1158..1252 CDD:206637 36/93 (39%)
Cadherin_repeat 1263..1361 CDD:206637 31/98 (32%)
Cadherin_repeat 1369..1481 CDD:206637 21/115 (18%)
Cadherin_repeat 1489..1598 CDD:206637 27/154 (18%)
Cadherin_repeat 1614..1710 CDD:206637 17/102 (17%)
Cadherin_repeat 1723..1843 CDD:206637 19/127 (15%)
Cadherin_repeat 1853..1948 CDD:206637 11/118 (9%)
Cadherin_repeat 1957..2053 CDD:206637 19/99 (19%)
Cadherin_repeat 2061..2154 CDD:206637 16/92 (17%)
Cadherin_repeat 2170..2318 CDD:206637 19/102 (19%)
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.