Protein Alignment Cad99C and PCDH11X

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_011529212.1
• Gene: PCDH11X / 27328
• HGNCID: 8656
• Length: 1376
• Species: Homo sapiens
• Alignment Length: 1255
• Identity: 300/1255 - (23%)
• Similarity: 480/1255 - (38%)
• Gaps: 316/1255 - (25%)

  Fly    61 PELPIFGD----------PD----TEIALNLVFPKGQ-PIFQL---------NGKKL---QLLQP 98
            ||..:.||          |:    |.:...||:..|. |:.::         .|.::   :|...
Human    64 PENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARIDREKLCAG 128

  Fly    99 LDRDEENLSHIVFQVSCTTRSTGKKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFR 163
            :.|||    |..::|..........|.:.|...:.|||||||.|..|...:::||::.:.:. :.
Human   129 IPRDE----HCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINSK-YT 188

  Fly   164 NIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPH---QGQVTVAKTLDFEKIQ 225
            ...|:|.|.|:||:..|.:.:    |.|:       :|...|..|.   ..|:.|.|.||.|:..
Human   189 LPAAVDPDVGINGVQNYELIK----SQNI-------FGLDVIETPEGDKMPQLIVQKELDREEKD 242

  Fly   226 TYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFIYSGCVSLDGACINPEYSASVPAGSL 290
            ||.:.:...|   ....:.|||..|.|::.|:||..|.|            ...|...|:|..:.
Human   243 TYVMKVKVED---GGFPQRSSTAILQVSVTDTNDNHPVF------------KETEIEVSIPENAP 292

  Fly   291 LGVLTVLPERIQAVDLDT-INSPIRYSFASGMPGNYA-DYFQIDESTGVLKQTKAVDTSTAKKYD 353
            :|....   ::.|.|.|. .|:.|.:|| |.:..|.| ..|.::.:||::...:.:|......:.
Human   293 VGTSVT---QLHATDADIGENAKIHFSF-SNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK 353

  Fly   354 IIVKAEEVSPGPQRFTTAKLEIFVKPVDANPP------VISSSQAEGYVDENSPIGTRV------ 406
            ::|.|.:....|.|   |.:.:.|..|:.|.|      :::.......:.||.|:.|::
Human   354 LLVLASDGGLMPAR---AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVT 415

  Fly   407 ---LDAHGNPISFMTTDADLSDSDPKPDYIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKF 468
               .|.:|....|  ||.::.         :.| .|.|:   :..|:.....||.:  :...:..
Human   416 DKDADHNGRVTCF--TDHEIP---------FRL-RPVFS---NQFLLETAAYLDYE--STKEYAI 463

  Fly   469 QVVAREPRTNAASAPLS----LTVHLRDVNDNAPKLAM-VAPISITAGDQSESRLVTQVTATDND 528
            :::|    .:|...||:    |.:.::|.|||||.... ...:||...:....:| |:|:|.|.|
Human   464 KLLA----ADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQL-TKVSAMDAD 523

  Fly   529 EGPNAVVTYSIYHVSNNGIQKFTINATTGEIRTQGRL--LAGEQYSITVQATDIG--GLSSQAIV 589
            .||||.:.|.:   ..:...:|:::..||.:....:|  ...::|..|:.|.|.|  .|:|...|
Human   524 SGPNAKINYLL---GPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTV 585

  Fly   590 EVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDP---ENDAVVYSIISGNDLRQFAV 651
            .||:. ..|...|.|....|...|.|....:.||.::...||   :|.||..||:..||  .|.:
Human   586 FVSII-DQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDEND--DFTI 647

  Fly   652 GQESGVIIVIRKLDRESLTRYQLILKAEDTGGL--SSSATVNIKVTDINDKNPEF--EASTLPYV 712
            ..::|||......|||....|...:||||.|.:  ||||.|.|.|.|:||..|.|  ..|...|.
Human   648 DSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE 712

  Fly   713 FQVEEGKAQASVGVVHATDADEGINAEITYSI----PTDIPFTINATSGEILTAKELDYEQLNEY 773
            ..:........|..|.|.|.|.|:|||:.|||    ..|: |.|:..:|.|...::.|...|..:
Human   713 LVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDL-FAIDQETGNITLMEKCDVTDLGLH 776

  Fly   774 KFVVTAKD-GAPDARLGTASVTVMVLD-------LPDEVPKFSDARI-------DVHIPENE-EN 822
            :.:|.|.| |.||:......|.:.|.:       :.:.|.|.::|.:       ||..|.:: ..
Human   777 RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPVTPNTEIADVSSPTSDYVK 841

  Fly   823 FLVATVQA--------FDPDSMPEITYVLRKGNAELFKVSEKSGE----------------VRTI 863
            .|||.|..        |       ||.|:|...|...|.::|:.:                ::..
Human   842 ILVAAVAGTITVVVVIF-------ITAVVRCRQAPHLKAAQKNKQNSEWATPNPENRQMIMMKKK 899

  Fly   864 KGLDYESQKQHQLTIGTIEN------DGNGPGDTILLVVDVEDRNDLPPRFITVPDPVTVNDDQG 922
            |.....|.|...|...|||.      |.:|...|:.|.:|:|::.  ..::..|..|.|...|
Human   900 KKKKKHSPKNLLLNFVTIEETKADDVDSDGNRVTLDLPIDLEEQT--MGKYNWVTTPTTFKPD-- 960

  Fly   923 IGTIIATLPAIDGDGTSPGNVVRYEIVGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRA 987
                            ||.....|:......|   ||:.|:|
Human   961 ----------------SPDLARHYKSASPQPA---FQIQPET----------------------- 983

  Fly   988 YDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGM----SSESIGLAFSDDSY---TTS 1045
                        ||. ..||::    .|:.|||...:...:    ||.|...:.||..|   |..
Human   984 ------------PLN-SKHHII----QELPLDNTFVACDSISKCSSSSSDPYSVSDCGYPVTTFE 1031

  Fly  1046 VPESMEANSTLKLIQIVNS--------------------KTSGD--GPPAFRCEF-------VSG 1081
            ||.|:.....:|  ::|.|                    |:.|.  |....|..|       .|.
Human  1032 VPVSVHTRPPMK--EVVRSCTPMKESTTMEIWIHPQPQRKSEGKVAGKSQRRVTFHLPEGSQESS 1094

  Fly  1082 NGGGI-----FNLSSADHGCNLLLIQPLDFENKSSYSLQLRLT-SHR-----------YFVNPLK 1129
            :.||:     .:|:|..||.      ||.:..:..:.   |.| |:|           .|:..||
Human  1095 SDGGLGDHDAGSLTSTSHGL------PLGYPQEEYFD---RATPSNRTEGDGNSDPESTFIPGLK 1150

  Fly  1130 DTTSVEI--IVQDENDNAPE 1147
            ....:.:  .|::.:||..:
Human  1151 KAAEITVQPTVEEASDNCTQ 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	21/98 (21%)
		Cadherin_repeat	146..259	CDD:206637	29/115 (25%)
		Cadherin_repeat	280..383	CDD:206637	25/104 (24%)
		Cadherin_repeat	393..496	CDD:206637	22/115 (19%)
		Cadherin_repeat	518..594	CDD:206637	25/79 (32%)
		Cadherin_repeat	608..699	CDD:206637	35/95 (37%)
		Cadherin_repeat	710..802	CDD:206637	28/103 (27%)
		Cadherin_repeat	814..903	CDD:206637	27/119 (23%)
		Cadherin_repeat	915..1005	CDD:206637	12/89 (13%)
		Cadherin_repeat	1041..1144	CDD:206637	30/153 (20%)
		Cadherin_repeat	1159..1264	CDD:206637
PCDH11X	XP_011529212.1	Cadherin_2	57..131	CDD:462413	12/66 (18%)
		Cadherin_repeat	172..274	CDD:206637	30/116 (26%)
		Cadherin_repeat	282..380	CDD:206637	25/104 (24%)
		CA	413..493	CDD:214520	20/100 (20%)
		Cadherin_repeat	501..595	CDD:206637	28/98 (29%)
		Cadherin_repeat	603..698	CDD:206637	36/96 (38%)
		Cadherin_repeat	710..801	CDD:206637	27/91 (30%)
		Protocadherin	804..1005	CDD:462451	51/270 (19%)
		FAM47	<1215..1283	CDD:405345