DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad99C and cdh-5

DIOPT Version :9

Sequence 1:	NP_001189311.1	Gene:	Cad99C / 43528	FlyBaseID:	FBgn0039709	Length:	1706	Species:	Drosophila melanogaster
Sequence 2:	NP_001343640.1	Gene:	cdh-5 / 177671	WormBaseID:	WBGene00000397	Length:	1449	Species:	Caenorhabditis elegans

Alignment Length:	1483	Identity:	336/1483 - (22%)
Similarity:	524/1483 - (35%)	Gaps:	452/1483 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 IGTRVL---DAHGNPISFMTTDADLSDSDPKPDYIYELT---TPSFNVTGDGILVVNEENLDRDP 460
            :||.|.   ::....:..:..|.||....|...|.|.||   ...|.|...|.:.:|...:|.||
Worm     1 MGTTVRVSPNSQSESLQILVNDEDLQPGMPPATYQYILTGLGATIFAVDQRGFVYLNVPKIDADP 65

  Fly   461 PAPGRFKFQVVAREPRT--NAASAPLSLTVHLRDVNDNAPKLAMVAPI----SITAGDQSESRLV 519
            |.|..::..|.|||..|  ...|.|:::|:|:.|:|||:|:...  ||    :..:||:   |.|
Worm    66 PNPSTYQLNVEAREVNTVPTRRSEPVTITIHILDINDNSPQFEQ--PIYMANTTASGDE---RDV 125

  Fly   520 TQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTGEIRTQGRLLAGEQYSITVQATDIGGLS 584
            .:|.|||.|.|....|||:|..|:|.|..||.....|..:...|.|:.||:|.:.::|.|.||.|
Worm   126 VKVVATDVDSGAFGQVTYTIAQVTNGGEDKFRYETATNMLVATGNLVPGERYQVVIEAIDGGGRS 190

  Fly   585 SQAIV-------------EVSVTPGPNTKPPR----FQKPIYEVQVSEGAE-INSTVTVVHAEDP 631
            |||||             .::..||..|..|.    ...|...|..:|..| |.:.||.|:...|
Worm   191 SQAIVIVLALDPMHQTFSSLAPLPGMETFMPNPLAMATTPGTMVTSAESEETIQTFVTEVNENTP 255

  Fly   632 ENDAVV------------YSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLILKAEDTGGL 684
            .|..||            ::::.||:..:||: .::|.|:...:||||....|.|.::.......
Worm   256 PNTVVVSLGDESSRELTYFNVVGGNEEGKFAI-DDAGTIVTAEELDREKTAMYSLQVETRSRNPD 319

  Fly   685 SSS--ATVNIKVTDINDKNPEFEASTLPY-------VFQVEEGKAQASVGVVHATDAD------- 733
            ...  ..|.:.|.|:||..|.|   |.|.       :..:|:......:|.:...|||
Worm   320 QHLYWTLVQVTVMDVNDNAPTF---TDPQPIRLRLSIDDIEQLTGNMIIGRIGVEDADADDNGRL 381

  Fly   734 ----------------EGI-------------------------------NAEITYSI------- 744
                            :||                               .|.:..||
Worm   382 ELRIMPPHNKLFAISNDGILSVNGDFTAAHFGEHDLTVVARDHGEPSLETRARVQISIFGTLITM 446

  Fly   745 ----PTD---------------------------IPFTINATSGEILTA---------------- 762
                ||:                           .|.|.|..|.:|.::
Worm   447 ATVAPTNEVFEYTSSVEEEPQTTNPDEHLQTVTTSPSTKNQVSQQIFSSFPAPQVEQTGAPVEPE 511

  Fly   763 -------------------KELDYEQLNEYKFVVTAKDG---APD------ARLGTASVTVM--- 796
                               .|.|.|..:||...|.....   |||      ....::|.|::
Worm   512 FPQFPTFPTLSPHPQIDEETEEDEEVTDEYPDTVATVPTVTVAPDYSEEYGQEASSSSSTILPDV 576

  Fly   797 ------VLDLPDE---------------------------------------------------- 803
                  :.:||.|
Worm   577 QGVWSEISELPSENPITYTESPITESTAPAPETSPETAPEITPERGSSAENELYPTEIAPENVEK 641

  Fly   804 ---------------------------------------------------------VPKFSDAR 811
                                                                     .|.|..::
Worm   642 PTELAPDLSETTENTENQWLPDVVETSQELPSLPTTKMAPPQPVPTQSPPLPTPKRLAPVFKPSQ 706

  Fly   812 IDVHIPENEENFLVATVQAFDPDSMP-EITYVLRKGNAELFKVSEKSGEVRTIKGLDYESQKQHQ 875
            |.|.|.|||....:....|..||.:. .|||||.||:..||.||..||.|..::.||.|:.....
Worm   707 ITVQIDENESQVEITKAHATYPDGLSGTITYVLHKGDPSLFSVSSYSGSVNLLRALDAETNSTVT 771

  Fly   876 LTIGTIENDGNGPGDT----------ILLVVDVEDRNDLPPRFITVPDPVTVNDDQGIGTIIATL 930
            :.|.|.|      ..|          :.:.::|.|:||..|.|.:......|.:|...|||:..:
Worm   772 IQISTSE------AQTLEVDPKLAHFVSITINVADKNDWIPNFESASYEFDVKEDTLPGTIVGQV 830

  Fly   931 PAIDGDGTSPGNVVRYEIVGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQL 995
            .|.|.|...|.|.:||.::..|....:|.|:.::|.:.:...:......:..:.|...|.|...|
Worm   831 NAFDQDRDEPNNRIRYRLLSAGGLEAHFNVNAESGLITLARPIDAFAGEKITLRIEGADSGMLPL 895

  Fly   996 SSVAPLRVDV----HHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTL 1056
            ||...:.::|    .||:...:......|:.|           |.||..:||.||.|::.....:
Worm   896 SSTTTVLINVVATSSHLIPDASPVSNTPNEGE-----------LQFSLRNYTASVSEAVRPPHLV 949

  Fly  1057 KLIQIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHG-CNLLLIQPLDFENKSSYSLQLRLTS 1120
            :::.::|..|.   .....|..:|||..|.|.:::.:.| |.|.....||.|....|.|.:.:|:
Worm   950 QVLSVMNKPTD---TRFIICNIISGNYRGAFGITAGNDGNCELRTQMELDRETVERYLLNITVTA 1011

  Fly  1121 HRYFVNPLKDTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSG 1185
                 ....|...|.|.|.|.|||.|.|.::...| ..|::..|:...:..|.:|.|:|.|.|.|
Worm  1012 -----GAQTDYALVSITVLDVNDNVPRFVYDSDLG-LTTYFGAVSSVANAFTRVLTVKAEDADLG 1070

  Fly  1186 KFGTVRYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHF-----KNENDFPLTFLVEARDS--DG 1243
            ....|.|.|     :.::..:.:|.:| ..|.:.|.:..     :|...| ..|.|.|.||  .|
Worm  1071 NSSLVNYAL-----DPLSAHSKYFSIS-PFGEISTKQSMSTILSRNRLQF-FEFRVSACDSPISG 1128

  Fly  1244 QEQGSHRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVS--GIERMSSQK 1306
            |:..|   :|.:|||.:...||..:......|..|:.:..:|.:...:.||..:  .||:|...
Worm  1129 QQLCS---KADVVVNVIGSTNRFKMIIYGLNPQQLKKHEKDLVKSTRQFTGSCNLLTIEKMIEH- 1189

  Fly  1307 YLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKD--SIVETTLLEPAARSELNIALPRATAENIS 1369
                  :.|||...|||::|.::|.|:::..::|  .:.||:          |:.|   .|..:.
Worm  1190 ------TAIENQIRTDIYWYAVNPTTKKICKKQDIRKLFETS----------NVQL---IAGKVQ 1235

  Fly  1370 --FPLER-----KEHVHKVKAAVAIDNEVFPFTLIAISLVILILGT-IGIIYICISWSKYKNFKQ 1426
              |.|||     .:..:.....:...|......|:.|..|.:.||. |||..:|:.||:||..::
Worm  1236 PWFRLERISEDAGDEGNMSSGGILSTNWKTSNILLIILAVTVALGAIIGICAVCVFWSRYKTAQR 1300

  Fly  1427 RMRQYSSTNP----PRYDPVIVNQQASSASETIANMKEYETQMLAMAVPPDVDDDLQLDFSAKNH 1487
            ....:|.:.|    |.|.|.::.....:.       .:||||.:.|.:.   |:||.:
Worm  1301 NASNFSHSYPQKLGPIYHPTMMGVDPRTE-------YDYETQNVNMLIS---DEDLTM------- 1348

  Fly  1488 AFSLDNVSYITHKENT-----------------NGGGQSS-------PSHSDA 1516
              ...::....|:..|                 ||.|..|       |:||.|
Worm  1349 --KSGSIGVPAHQRMTLMGAGGGPGMGGPGGPQNGQGNQSYRTYGYRPAHSTA 1399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_001189311.1	Cadherin_repeat	<68..138	CDD:206637
		Cadherin_repeat	146..259	CDD:206637
		Cadherin_repeat	280..383	CDD:206637
		Cadherin_repeat	393..496	CDD:206637	31/101 (31%)
		Cadherin_repeat	518..594	CDD:206637	32/88 (36%)
		Cadherin_repeat	608..699	CDD:206637	26/105 (25%)
		Cadherin_repeat	710..802	CDD:206637	30/243 (12%)
		Cadherin_repeat	814..903	CDD:206637	31/99 (31%)
		Cadherin_repeat	915..1005	CDD:206637	22/89 (25%)
		Cadherin_repeat	1041..1144	CDD:206637	28/103 (27%)
		Cadherin_repeat	1159..1264	CDD:206637	30/111 (27%)
cdh-5	NP_001343640.1	Cadherin_repeat	4..103	CDD:206637	29/98 (30%)
		Cadherin_repeat	125..201	CDD:206637	32/75 (43%)
		Cadherin_repeat	245..337	CDD:206637	23/92 (25%)
		Cadherin_repeat	364..439	CDD:206637	7/74 (9%)
		Atrophin-1	<447..728	CDD:331285	30/280 (11%)
		PRK11633	<596..>701	CDD:236940	0/104 (0%)
		Cadherin_repeat	706..803	CDD:206637	32/102 (31%)
		Cadherin_repeat	812..906	CDD:206637	22/93 (24%)
		Cadherin_repeat	935..1030	CDD:206637	28/102 (27%)
		Cadherin_repeat	1044..1142	CDD:206637	30/107 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I8127
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23401
Inparanoid	1	1.050	322	1.000	Inparanoid score	I1480
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47650
OrthoDB	1	1.010	-	-		D15091at33208
OrthoFinder	1	1.000	-	-		FOG0005384
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109439
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5325
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.910