Protein Alignment Cad99C and Cdhr5

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: NP_612534.1
• Gene: Cdhr5 / 171554
• RGDID: 620504
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 644
• Identity: 162/644 - (25%)
• Similarity: 238/644 - (36%)
• Gaps: 101/644 - (15%)

  Fly     1 MAARNSLTPQQGLGFFGLLILLCSAVLGKSQMCEVETGQTNIILDIEESRESFIGQPTTPPELPI 65
            |.|...|.|...|....:|.......|.::|:|  ...||  :..:.|:      ...:.|...|
  Rat     1 MGAPALLWPPLLLPLLTVLFGHLPGTLAQAQVC--SANQT--VFTMNEN------TTVSGPLADI 55

  Fly    66 FGDPDTEIAL-NLVFPKGQPIFQLNGKKLQLLQPLDRDEENLSHIVFQVSCTTRSTGKKRTIPII 129
            |...|..:.| .|..|..   |::.|.||.|:...|.:|.:|...|.:..   |.........:.
  Rat    56 FVPEDQYVTLGQLSTPNA---FKVEGNKLFLIVTPDYEENSLLEAVLECK---RGDTLVTQFRVF 114

  Fly   130 VRVSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNVEK 194
            |.|.|||||||.|..|..|..|.|.|.|.|.:....:....||..:.::.|.:.|.:||::..
  Rat   115 VAVLDINDNAPEFPFTIKEYNVSEDTRVNTIVIPETELKATDADKDDILVYTLQEVTPNASKF-- 177

  Fly   195 YSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASD-RARNTADRLSSTTTLTVNIADSN 258
            :|..|..:.|:.        :.:|||:.|.......::|.| |..|.....::|.|:.:|:..::
  Rat   178 FSLVGINSPALK--------LDQTLDYYKSPNMTFRLLARDTREENVIPSHTATATVVLNVLPAD 234

  Fly   259 DLDPSFIYSGCVSLDGACINPEYSASVPAG-SLLGVLTVLPERIQAVDLD-TINSPIRYSFASGM 321
            ...|.|:...... |..||..:|...:|.| .|...|.:.|..|.|||.| .||.||.||.   |
  Rat   235 LRTPWFLPCSFTD-DYFCIQAQYHTVIPTGHKLPSPLILSPGPIYAVDGDQAINQPIVYSI---M 295

  Fly   322 PGNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDANPPV 386
            .||..|.|.|::..|.|...|::.:...  :.::|:||:....  |::..:..:..:.|..||..
  Rat   296 MGNTDDTFIINKDDGNLTMAKSIPSPMT--FTLVVRAEQADMA--RYSVTQAVVEARDVTGNPLQ 356

  Fly   387 ISSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDAD-LSDSDPKPDYIYELTTPSFNVTGDGILV 450
            .|.|...|.|...|..||.|.| ...|...:...|. |...|......|::|..|..:....||:
  Rat   357 FSQSLYFGTVVLGSEAGTAVKD-KTFPSEILRIQAQYLGFPDLNSAVTYQVTNSSEFIMNKDILL 420

  Fly   451 --------------VNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLA 501
                          |...|......|....:.||..|||.:..:..|              |:..
  Rat   421 TTVPMETERTIRIEVEANNTVTKDIATTIVEIQVSEREPPSTESPTP--------------PEAG 471

  Fly   502 MVAPISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTGEIRTQGRLL 566
            .      |.|..|.:.|.|..| :...:||   .|.|    |......|....||....|....:
  Rat   472 G------TTGPSSNTTLETPST-SGTSQGP---ATTS----SGGSAGPFPPAGTTLSPLTSAPTV 522

  Fly   567 AGEQ----YSITVQATDIGGLSSQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINS 621
            .|..    .|.:.|....||.::|       ||.|.|..|....|        ||..:|
  Rat   523 PGGSPTLGISTSPQTATPGGDATQ-------TPKPGTSQPMVPTP--------GASTSS 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	21/72 (29%)
		Cadherin_repeat	146..259	CDD:206637	26/113 (23%)
		Cadherin_repeat	280..383	CDD:206637	31/104 (30%)
		Cadherin_repeat	393..496	CDD:206637	25/117 (21%)
		Cadherin_repeat	518..594	CDD:206637	18/79 (23%)
		Cadherin_repeat	608..699	CDD:206637	3/14 (21%)
		Cadherin_repeat	710..802	CDD:206637
		Cadherin_repeat	814..903	CDD:206637
		Cadherin_repeat	915..1005	CDD:206637
		Cadherin_repeat	1041..1144	CDD:206637
		Cadherin_repeat	1159..1264	CDD:206637
Cdhr5	NP_612534.1	Cadherin_repeat	133..231	CDD:206637	26/107 (24%)
		Cadherin_repeat	255..353	CDD:206637	31/104 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..658		37/158 (23%)
		Herpes_BLLF1	<470..>650	CDD:282904	30/126 (24%)
		4 X 31 AA approximate tandem repeats	545..648		10/37 (27%)
		Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9HBB8	693..862
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..803
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	821..862