Protein Alignment Cad99C and ds

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_061514261.1
• Gene: ds / 1278050
• VectorBaseID: AGAMI1_006399
• Length: 3489
• Species: Anopheles gambiae
• Alignment Length: 2050
• Identity: 463/2050 - (22%)
• Similarity: 757/2050 - (36%)
• Gaps: 588/2050 - (28%)

  Fly     3 ARNSLTPQQGLGFFGL-------LILLCSAVLGKS-------QMCEVETGQTNI---------IL 44
            |..::|...|.|.|||       .:::.|..|.:.       .:...:||...:         :.
Mosquito   409 ANVNVTLSGGEGHFGLTTRDNIIYLVIVSLPLDREIKPNYTLSVIATDTGNPPLHAAKDIFLTVT 473

  Fly    45 DIEESRESFIGQPTTPPELPIFGDPDTEIALNLVFPKGQPIFQLNGKKLQLLQPLDRDEENLSHI 109
            ||.::...|        |..::.....|:|     ..|..:.|:..        :||||.|.|.|
Mosquito   474 DINDNAPEF--------EKDVYHANVMEVA-----DPGTSVIQVTA--------VDRDEGNNSAI 517

  Fly   110 V-------------FQVS-----CTTRSTGKKRTIP---------------------IIVRVSDI 135
            |             ||:.     .|||:.....|.|                     ::|.:.|:
Mosquito   518 VYSLLDTPDTHSHWFQIDSHSGLITTRAHIDCETDPVPQLIVMAQDNGRPPLSSTGTVLVTIHDV 582

  Fly   136 NDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGY 200
            |||.|.|..:.|.|:|.|:...|..|.: :.|.|.|.|||.:|.|.:.||...:...|
Mosquito   583 NDNEPIFDQSFYNVSVAENESKGRCILK-VSATDPDCGVNAMVNYTLGEGYKKNAEFE------- 639

  Fly   201 GTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFI 265
                 ..|..|:|.:|..||:|...:|...|:|:||.     .||:|..:.:.:.|.||..|:|.
Mosquito   640 -----IRPSTGEVCIASELDYETRNSYEFPIIATDRG-----GLSTTAMVKIQLTDVNDNRPTFY 694

  Fly   266 ---YSGCVSLDGACINPEYSASVPAGSLLGVLTVLPERIQAVDLDTIN-SPIRYSFASGMPGNYA 326
               |:  |||         ..|:|..|||....|:   :.|.|.|:.: ..|.|...:   ||.|
Mosquito   695 PREYN--VSL---------RESMPTNSLLSTPVVV---VVATDSDSGSFGTISYRIVA---GNEA 742

  Fly   327 DYFQIDESTGVLKQTK--AVDTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDA--NPPVI 387
            ..|::|..||.:..|:  .:.:.|...:.:.:.|   |.|....:|...|:|:..:||  .||:.
Mosquito   743 GIFRMDRLTGEIFVTRPNMLSSRTQPYHRLNISA---SDGGGLRSTHDAEVFISVIDATQRPPIF 804

  Fly   388 SSSQAEGYVDE----NSPIGT--------------RVLDAHGNPISFMTTD--------ADLSDS 426
            ...:...||.|    |:.:||              |.....|:|..|...|        |:..|.
Mosquito   805 DKPRYTYYVKEDVKRNTVVGTVSATSSNSGNRGSLRYFIYSGDPDGFFAIDPVSGNIRVANALDH 869

  Fly   427 DPKPDYIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLR 491
            :.||.                 :::|.:....||||.|.                  ..:.:.:.
Mosquito   870 ETKPQ-----------------VLLNIQATSGDPPAYGH------------------TQVNIDIE 899

  Fly   492 DVNDNAPKL-AMVAPISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSN--NGIQK--FT 551
            |||||.|:. :....||:....:..|.|. :..|.|.|.|.:.|:||.:....|  :|.:.  |:
Mosquito   900 DVNDNPPEFESNTVRISVPENVEIGSPLY-EANAQDKDSGMSGVITYMLAGQGNTLSGARSSLFS 963

  Fly   552 INATTGEIRTQGRLL---AGEQYSITVQATDIG--GLSSQAIVEVSVTPGPNTKPPRFQKPIYEV 611
            :::.:|.: |..|.|   :.:::::.|.|:|.|  .||:...:.|.| ...|...|.|:|..|.:
Mosquito   964 MDSRSGHL-TLARPLDYESMQRHTLVVTASDSGTPSLSTNLTILVEV-QDVNDNAPIFEKNEYAI 1026

  Fly   612 QVSEGAEINSTVTVVHAEDPE---NDAVVYSIISGNDLRQ-----------------FAVGQESG 656
            .|.|....||.:..|.|.|.:   |..:.|.|: |.|.::                 |.:...||
Mosquito  1027 SVIESTPSNSQILQVSATDADTGNNARLTYKIL-GEDHQRTGKSTQPASPDEPVAEIFGIFPNSG 1090

  Fly   657 VIIVIRKLDRESLTRYQLILKAEDTGGLSSSATVNIKVT--DINDKNPEFEASTLPYVFQVEEG- 718
            .|.:..|||||...||.:.:...|.|..:.:||.::.||  |.||.:|.|..|.  |.|::||.
Mosquito  1091 WIYLRTKLDREVKERYNITVIVSDNGVPTLTATAHVIVTILDANDNSPIFAKSL--YEFEIEENM 1153

  Fly   719 KAQASVGVVHATDADEGINAEITYS-IPTDIPFTINATSGEILTAKELDYEQLNEYKFVVTAKDG 782
            :..|.:|.|.|:|:|.||||.:.|| ||::..|.||..||||.|...||.|....|..||.|:|.
Mosquito  1154 RRGAMIGTVSASDSDAGINAVVRYSLIPSNTSFQINPVSGEITTRDSLDRETKASYDLVVEARDQ 1218

  Fly   783 APDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENEENFL---VATVQAFDPD--SMPEITYV 842
            ....|....||.|.:||:.|..|...|.:.|| :...||..:   |..|:|.|.|  ....|:|.
Mosquito  1219 GTPYRSSRVSVKVQILDVNDNAPDIVDPQEDV-VSVREEQPIGTEVVKVRAIDRDHGQNASISYS 1282

  Fly   843 LRKGNAE----LFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTI-LLVVDVEDRN 902
            :.||...    :|.:...||.:||...||:|.:..::|.:...:| |..|..|: ||.::|.|.|
Mosquito  1283 ILKGRDSDGYGMFSIDPMSGVIRTKTSLDHEEKTIYRLAVAATDN-GKPPKQTVRLLRIEVLDLN 1346

  Fly   903 DLPPRFITVPDPVTVNDDQGIGTIIATLPAIDGD---------GTSPGNVVRYEI------VGRG 952
            |..|.|.:......:.:|.|:|.||.   :|.|:         .:|....:.|.:      :..|
Mosquito  1347 DNRPTFTSSSLVFRLREDVGVGHIIG---SISGNEQSDAENFISSSSDLHITYTLTPLTNDITEG 1408

  Fly   953 KAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDL---GEPQLSSVAPLRVDVHHLLSSGNN 1014
            .    |.:|.::|.:.:..:|.:|:.:||:::|||.|.   ..||.|:|..
Mosquito  1409 A----FDIDRNSGKLVVARQLDREQQSEYRMEIRALDTSASNNPQSSAVTV-------------- 1455

  Fly  1015 EIKLDNKLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFV 1079
            :|::.:..::.....|:.|.:..|:|:...:               ||.:.|..|.......|..
Mosquito  1456 KIEIADVNDNPPKWPSDPINVYVSEDTPVGA---------------IVYNFTVQDNDTGTNAEIK 1505

  Fly  1080 SGNGGGIFNLSSADHGC------------NLLLIQPLDFENKSSYSLQLRLTSHRYFVNP-LKDT 1131
                   :|||...|..            :|.|:.|||.|:...:.|.::.|.....|.. |..:
Mosquito  1506 -------YNLSKPAHLAQKEYFAIDSLTGSLTLLAPLDHEDTQEFLLIVQATDQSSNVTERLTTS 1563

  Fly  1132 TSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGKFGTVRYTLY- 1195
            .:..|||.|.|||:|:|    :..|.......:::.:::|..:..|.|.|.|||:.|.:.||..
Mosquito  1564 ATARIIVTDVNDNSPKF----VIPQAADGVVYISDSLEIDQVVSHVVAIDPDSGENGHIAYTFVG 1624

  Fly  1196 -DDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFLVEA--RDS---------DGQEQGS 1248
             ::||.        |.:...|||:|.||.|.:      .|::::  |:|         ...:.||
Mosquito  1625 GNEDER--------FTIDSSTGVIRLAKPFSS------NFIMDSGKRNSVSGKYQLVISASDHGS 1675

  Fly  1249 HRTR-----ARIVVNKLAD------------------------INRMALSFPNAAPSDLRNYYTE 1284
            .|.|     .::|:..:.:                        :...|.|..:.......|...|
Mosquito  1676 PRPREAKMTLQVVIQNMTNNPPRFVEPVYHVNITENVPSGSFVVRVSARSHSDGGSGAGLNLTYE 1740

  Fly  1285 LEE-------LLDKKTGLVS---GIERMSSQKY----LAKNGSVIENPAA--------------- 1320
            :.:       .:|...|:|:   ..:|.|...|    ....|...:.|::
Mosquito  1741 IPKGVGEDHFAVDSVRGIVTTRGTFDRESKDLYTIPIYVTEGGRFKKPSSSAASSQDMAQFDVAT 1805

  Fly  1321 -----TDI-----------WFYLIDPKTEQLVSRKDSIVETTLLEPA---ARSELNIALPRATAE 1366
                 ||:           .:.|..|:..:|     ||:.|.:...|   ...|:..::......
Mosquito  1806 LVVRVTDVNDHAPEFVQGSCYPLAVPENSEL-----SIIHTVVATDADDGLNGEITYSISGGNMG 1865

  Fly  1367 N-----------ISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYICISWSK 1420
            |           .:.||:|:.|...|....|.|.                 |:      .:|...
Mosquito  1866 NKFSIDLHTGALTARPLDREVHARYVLQITAQDR-----------------GS------PVSHQG 1907

  Fly  1421 YKNFKQRMRQYSSTNPPRYDPVIVNQQASSASETIANMKE----YETQMLAMAVPPDVDDDLQLD 1481
            :.|...|:.. .:.|.|:::          ..:.||.:.|    ..|.:...|:..||..:.::.
Mosquito  1908 HCNITIRVED-ENDNDPKFE----------LQKYIATIDEDAQIGTTVLTVKAIDADVGINARIV 1961

  Fly  1482 FSAKN---HAFSLDN-VSYIT-------HKENT--------NGGGQSSPSHSDATTATIATLRRH 1527
            :|..|   ..|.:|: ...||       .::|.        :||..::.|.:......||.:..:
Mosquito  1962 YSLANVTEWLFDIDSKTGVITTAGLFDRERQNVYNFMVVAMDGGRYNARSQNVPVQVIIADVNDN 2026

  Fly  1528 KNL---------------------------NNASMNNNLAINNRQNTFNRTLEMNTRNNANPLAS 1565
            |.:                           ::...|..:..:..:|..|....:|
Mosquito  2027 KPVFDKYPFREQIGALVQPGQTLLHISATDSDQGSNGEIVYSLNENASNGKFRIN---------- 2081

  Fly  1566 PPNGALSGTLTL----GRIKH------QNSN-----------------------HYQNGAYNI-- 1595
            |..||||.|.:|    ||:.|      ...|                       .:||.:|.:
Mosquito  2082 PTTGALSATQSLASENGRLLHIEVTARDKGNPPQIATGLIELRVGEVQQELPVLRFQNSSYRVTL 2146

  Fly  1596 DPTGPNNMAHAKNNAYSTMGRRGNTFGDVGLLNGNGELMNATLGRNGQLNNRLYGGEVPITNPLF 1660
            ....|......:.:|..:.|||.......|  :||         .:|..:.....|:|.|.|
Mosquito  2147 SENTPVGQPVLQLSAVRSDGRRQKIIYSFG--SGN---------EDGTFSIDAVTGDVRIRN--- 2197

  Fly  1661 QRSNSDHNHLSSTN----ENVSFGKRDYGQIGFSY 1691
             ..|.|:...|...    |.|:..:.|...:.:.|
Mosquito  2198 -SHNLDYERFSRLKSEGIELVAVARTDGTPLLYGY 2231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	24/110 (22%)
		Cadherin_repeat	146..259	CDD:206637	33/112 (29%)
		Cadherin_repeat	280..383	CDD:206637	28/107 (26%)
		Cadherin_repeat	393..496	CDD:206637	24/128 (19%)
		Cadherin_repeat	518..594	CDD:206637	22/84 (26%)
		Cadherin_repeat	608..699	CDD:206637	31/112 (28%)
		Cadherin_repeat	710..802	CDD:206637	40/93 (43%)
		Cadherin_repeat	814..903	CDD:206637	29/98 (30%)
		Cadherin_repeat	915..1005	CDD:206637	25/107 (23%)
		Cadherin_repeat	1041..1144	CDD:206637	24/115 (21%)
		Cadherin_repeat	1159..1264	CDD:206637	28/146 (19%)
ds	XP_061514261.1	None