Protein Alignment Cad99C and Cad74A

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_316322.5
• Gene: Cad74A / 1276914
• VectorBaseID: AGAMI1_014484
• Length: 1829
• Species: Anopheles gambiae
• Alignment Length: 1585
• Identity: 388/1585 - (24%)
• Similarity: 650/1585 - (41%)
• Gaps: 326/1585 - (20%)

  Fly    17 GLLILLCSAVLGKSQMCEVETGQTNIILDIEESRESFIGQPTTPPELPIFGDPDTEIALNLV--- 78
            ||.|::....||.:      :..|..:.::..|...|...||.       |:..|.|.:.::
Mosquito   408 GLAIVVTDRDLGPN------SHYTLALRNLHNSEGVFAVVPTQ-------GEGRTPIVVKVLDSS 459

  Fly    79 -FPKGQPIFQLNGKKLQLLQPLDRDEENLSHIVFQVSCTTRSTGKKRTIPIIVRVSDINDNAPRF 142
             .....|..:....:.||:..:|.:|                   |.|..:.||:.|.|||:|.|
Mosquito   460 RLDYDVPSEEAKTFRFQLVASVDGEE-------------------KSTANVTVRLQDANDNSPTF 505

  Fly   143 MNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGT-FAIS 206
            ....|.:.|.|::|.|..| .::.|.|.|||:.|.:               .|:..|:|. |..:
Mosquito   506 PQASYSLQVRENSPQGFKI-ADLSATDHDAGMFGQL---------------AYAVKGFGAEFFRT 554

  Fly   207 FPHQGQVTVAKTLDFEKIQTYYLTIVASD-RARNTADRLSSTTTLTVNIADSNDLDPSFIYSGCV 270
            .|.:|.:.|.:.||:|:.::|.|.:||.| ..|.|      ...:.:::.|.||..|:|     .
Mosquito   555 HPTEGGLYVERQLDYEEQKSYSLALVARDGGGRET------NANVFIDVMDENDNHPAF-----E 608

  Fly   271 SLDGACINPEYSASVPAGSLLGVLTVLPER--IQAVDLDTINSPI----RYSFASGMPGNYADY- 328
            :|       ||:.::..|:     |....:  ::|||:|   .|.    |.|:|.....:.:.:
Mosquito   609 AL-------EYTRTIREGA-----TEFEPQFFVRAVDVD---GPTQGGGRVSYAIESENSISGHV 658

  Fly   329 FQIDESTGVLKQTKAV---DTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDANPPVISSS 390
            |.:|..:|.:|.|:.|   ||... :|:::|.|.:....|.:..|..| :.|.......|:....
Mosquito   659 FTVDRDSGEIKITRPVSSMDTDRG-QYELLVVATDHGVPPLKNDTRVL-VRVGLSGNQRPIFRGH 721

  Fly   391 QAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDSDPKPDYI-YELTTPSFN-VTGD--GILVV 451
            ...|..|...|...|.......|..:..|....:|.|...:.: |::...|.| |..|  |::.|
Mosquito   722 ATAGNRDIPGPPSYRASIPENAPAGYNVTQVSATDPDGLDELLRYKIVGASDNFVINDLTGLITV 786

  Fly   452 NEE-NLDRDPPAPGRFKFQVVAREPRTNAASAPL----SLTVH--LRDVNDNAPKL---AMVAPI 506
            ..: .|||| ..|..:...|.|.:     |..|:    :.|||  ::|:||..||.   :..|.:
Mosquito   787 TRDARLDRD-TNPESYAIVVNAID-----AGFPIPETATTTVHVKIQDINDKPPKFTQQSYTAYV 845

  Fly   507 SITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYH----VSNNGI-----------QKFTINATT 556
            |..:...||   |.:|||.|.|  .:|.:.|::..    |:..||           |.|.|:...
Mosquito   846 SERSAIDSE---VLRVTAKDTD--LSARIEYALVEPITAVTKGGIPLLTTSSYDYRQAFRIDRDD 905

  Fly   557 GEIRTQGRLLAGEQY----SITVQATDIGG------LSSQAIVEVSVTPGPNTKPPRFQ------ 605
            |.|.....|  ...|    ::||:|||...      ...|..|.:.|....:|. |.|:
Mosquito   906 GTIFVNSTL--NYNYAAVITLTVRATDTAAELYPERQFDQTEVTLYVQSFKDTN-PLFRNKGWST 967

  Fly   606 -KPIYEVQVSEGAEINSTVTVVHAEDPENDAVV--YSIISGNDLRQFAVGQESGVIIVIRKLDRE 667
             :|..||:|.|.|.:.|.|..:.|:||..|..:  :.::..:....|.:.:.:|.|:::::||.|
Mosquito   968 VRPKIEVKVKEEAPVGSVVFRIEADDPVADVPITDFELMMPDVDGIFGLNERTGEIMLLQRLDYE 1032

  Fly   668 SL--TRYQLILKAEDTGGLSSS-ATVNIKVTDINDKNPEFEASTLPYVFQVEEGKAQASVGVVHA 729
            :.  |....::||..:.....| |.||:.|.::||..|.||..:. .|..:|..:....|..|.|
Mosquito  1033 TYNKTTIDFVVKAITSNRKRHSLAYVNVTVENVNDNAPVFERDSY-RVTVLESDRYPHVVTTVSA 1096

  Fly   730 TDADE---------GINAEITYSI---PTDIPFTINATSGEIL--TAKELDYEQLNEYKFVVTAK 780
            ||.|.         |.|. |.||:   .::: |||:..:|||.  ..:.||.|:.:..|.:|.|:
Mosquito  1097 TDQDVVRTEKDTLLGYNV-IRYSLFGSHSNL-FTIDNQTGEIRIGPGQVLDREKQSVLKLIVVAE 1159

  Fly   781 D--GAP-DARLGTASVTVMVLDLPDEVPKFSDARIDVHIPEN--EENFLVATVQAFDPDS--MPE 838
            |  |.| ||:..|..|.|.|||:.|..|.|........||||  .:.|::| :.|.|||.  ..|
Mosquito  1160 DAPGRPQDAKKATTEVMVDVLDVNDNAPIFGQRSYTAVIPENVLVDTFVIA-ITAHDPDEGLGGE 1223

  Fly   839 ITY-VLRKGNAE-LFKVSEKSGEVRTIKGLDYESQKQ-HQLTIGTIENDGNGPGDTIL------- 893
            :.| :|.:|.|. |.:::.|:||::|...|..:.:.: ::|.|...::.|..|..:.|
Mosquito  1224 VRYDILNEGEANGLLQINPKTGEIKTKSMLTGKGRAEPYELVIRAQDSGGQLPKQSSLYNDVSFT 1288

  Fly   894 LVVDVEDRNDLPPRFIT--VPDPVTVNDDQGIGTIIATLPAIDGDG-TSPGNVVRYEIVGRGKAP 955
            |.:.....||..|.||.  |.....|.::..:|..:..:.|.|.|. .:|...:||.|....:..
Mosquito  1289 LYIGDISANDGIPFFIAPQVGQTANVTENATVGAPVFQVIASDPDSPATPSGTLRYRIQSDIEDA 1353

  Fly   956 KYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDN 1020
            |.|.::..||.:.....|.:|..:.|.:.|...|:|||..:|...||::|   |...::|.:...
Mosquito  1354 KSFNINAKTGLITTTRSLDREIKSTYNIIIEVSDMGEPPQASTVVLRINV---LDIDDHEPRFVR 1415

  Fly  1021 KLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNGGG 1085
            ::|:               ..|...|.|...|.:.:..:..::.....:|  |.....:.||..|
Mosquito  1416 EVEA---------------QPYELEVLEEQPAGTIVGNVSALDEDVGPNG--AINYIIIDGNELG 1463

  Fly  1086 IFNLS-SADHGCNLLLIQPLDFENKSSYSLQLRLTSHRYFVNPL-------KDTTSVEIIVQ--D 1140
            :||:: :.|:...:...:|||.|...|..|.:|........:||       .|.:.::::::  |
Mosquito  1464 LFNVTRTEDNQAIIRTKKPLDRETLESVRLTIRCFKLNTVPDPLMHESYNRHDKSQLQLLIRVLD 1528

  Fly  1141 ENDNAPEFEFNRLRGQQDTFYTV-VTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDD------ 1198
            .:|:||.||    |..|    |: :...:.:||.|...||.|.|.    |.|..:|...
Mosquito  1529 IDDHAPRFE----RENQ----TIGIRHNVPIDTPIANGRAFDEDP----TARPIVYSIQSINFVP 1581

  Fly  1199 -----ENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSHRTRARIVVN 1258
                 :||.......|.::.||..:||.:...|..|.....:|.|.:||..|:.| .|:.:|.|.
Mosquito  1582 QFYRRDNRTEEYGDVFSLNPDTAEIRTTRSMSNFVDGYFQLMVRAANSDEAERIS-ETQMKIFVI 1645

  Fly  1259 KLADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVSGIERMSSQ--KYLAKNGSVIENP--- 1318
            :...:.|...|.|.          ||:..:||:.|  |...||:::.  :....:..|:..|
Mosquito  1646 RDKSLLRFVFSRPP----------TEVSGVLDRFT--VEMQERLANANLELSVFDAQVLSQPDHS 1698

  Fly  1319 ---AATDIWFYL------IDPKTEQLVSRKDSIVETTLLEPAARSELNIALPRATAENISFPLER 1374
               ::|...|.|      :.| .|.:....|:.::.||.|                      :..
Mosquito  1699 LDFSSTSSCFQLTRHGSALTP-VEMMRIMDDAEMKETLAE----------------------VYH 1740

  Fly  1375 KEHVHKVKAAVAIDNEVFPFTLIAIS--LVILILGTIG-------IIYICISWSKYKNFKQRMRQ 1430
            :..|||:.:. |:..:.....|||.|  .::::.|.||       :...|::    |.:|.::|.
Mosquito  1741 RYSVHKIDSC-AVSKKPPATALIASSGTWLVILAGLIGFAAFASTMTACCLA----KRYKNQVRS 1800

  Fly  1431 ------------YSSTNPPRY-DPV 1442
                        |.|..|..| :|:
Mosquito  1801 TINSQRIVGSDIYGSATPVLYTEPI 1825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	15/75 (20%)
		Cadherin_repeat	146..259	CDD:206637	30/114 (26%)
		Cadherin_repeat	280..383	CDD:206637	27/112 (24%)
		Cadherin_repeat	393..496	CDD:206637	29/113 (26%)
		Cadherin_repeat	518..594	CDD:206637	25/100 (25%)
		Cadherin_repeat	608..699	CDD:206637	25/95 (26%)
		Cadherin_repeat	710..802	CDD:206637	36/108 (33%)
		Cadherin_repeat	814..903	CDD:206637	27/102 (26%)
		Cadherin_repeat	915..1005	CDD:206637	24/90 (27%)
		Cadherin_repeat	1041..1144	CDD:206637	23/112 (21%)
		Cadherin_repeat	1159..1264	CDD:206637	29/116 (25%)
Cad74A	XP_316322.5	None