Protein Alignment Cad99C and Cad89D

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_061499378.1
• Gene: Cad89D / 1273990
• VectorBaseID: AGAMI1_002514
• Length: 2001
• Species: Anopheles gambiae
• Alignment Length: 1809
• Identity: 383/1809 - (21%)
• Similarity: 602/1809 - (33%)
• Gaps: 639/1809 - (35%)

  Fly     7 LTPQQGLGFFGLLILLCSAVLGKSQM-CEVETGQTN------------IILDIEESRESFIGQPT 58
            ::|:.|:.|....|.|.|..|..:.. .::|..|.|            .::|:.::...|
Mosquito   320 ISPETGVLFLQKEIDLDSESLPDNTFTLQIEAQQINDPTKSAFARVDIEVIDLNDNVPEF----- 379

  Fly    59 TPPELPIFGDPDTEIALNLVFPKGQPIFQLNGKKLQLLQPLDRDE-ENLS--------------- 107
               |:.::   :..|..||  |||..|.|:|.        :|||: ||..
Mosquito   380 ---EVDLY---NISIIENL--PKGFSILQVNA--------IDRDQGENAEFYYYLMDEEPKGAFM 428

  Fly   108 ----------------------------HIVFQVSCTTRST--GKKRTIPIIVRVSDINDNAPRF 142
                                        |.|.:|....||.  ||   :.:.:.:.|.|||.|.|
Mosquito   429 IDHGSGWIVVRDETFLDKEQRSSLKMNVHAVERVEQYDRSRNYGK---VQVEITLLDTNDNTPEF 490

  Fly   143 -MNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAIS 206
             ..|.||.....:..:|:.: ..|:|||.|...||.::|.|....||              ..|.
Mosquito   491 EQGTLYEFKTHCNASIGSKV-GQIRALDPDDLGNGKIQYSIKNVRPN--------------LVIP 540

  Fly   207 F---PHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFI--- 265
            |   |..|.:.|::.|.:.||..:   :.|.|:.:|.::...:...:|::|...:..|..||
Mosquito   541 FLLDPDTGDIRVSEALTYGKIAFF---VEARDQPQNPSESRFNVALVTIDIVCQSIEDIEFIGAP 602

  Fly   266 YSGCVSLDGA-------------CINPE---------YSASVPAG--SLLGVLTV---------- 296
            |...|..|.|             .::.|         |...||..  ...|::||
Mosquito   603 YEFWVGADAAIGSSVGQIRTTFDMVSDEEIFFDLLHSYPEGVPFAIEERSGIVTVIESMEKFDRR 667

  Fly   297 ----------LPE----RIQAVDLDTINS---------------------------PIRYSFASG 320
                      ||:    .::.:..:..||                           ||.:.....
Mosquito   668 CYEFETVVSYLPDSAGKNVEQLTPEAYNSLEKIIVTNVTIHVIKHNFMLLRGTNATPIEFRVKEN 732

  Fly   321 MPG--------------------------------NYAD--YFQID------------------- 332
            .|.                                |.||  .||::
Mosquito   733 KPNTMIGQLKFQDFQEQCDADEKGLPPLISVRGDKNRADRQVFQLNGGKNRTRYARRFSRDVSRQ 797

  Fly   333 ----------------ESTG--------VLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAK- 372
                            .|||        ....|..|..|....||:.......:.|  :..|.|
Mosquito   798 SNFIRLYPLVAFDAVFSSTGNGTRKARNSRNPTSGVQYSLVNSYDVADTVRLTNDG--KLMTIKG 860

  Fly   373 -----------------------------LEIFVKPVDANPPVISSSQAEGYVDENSPIGTRVLD 408
                                         :.|.|:..:.|||..:.....|.:.|||||||.::
Mosquito   861 LDREKQDVIRVTIIAEYFYKQRTFAGIYQVVIVVEDENDNPPTFNQPFFLGVIAENSPIGTEIV- 924

  Fly   409 AHGNPISFMTTDA-----------------------------------------DLSDSDP---- 428
             ..|||.....||                                         .:::.||
Mosquito   925 -LNNPIIISDMDAAGPNSEYELLLSGESNSFVAQFSNSTLSNYNKTVAHIFRNLQIANIDPGESR 988

  Fly   429 -KPDY-------IYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLS 485
             :|||       ....:||.:|     ||.:....|||:.......|.....|:   |..| .:.
Mosquito   989 LRPDYRPNKQLEPGNASTPHYN-----ILFMGPNKLDREEIESLTLKMMATDRD---NLMS-EVE 1044

  Fly   486 LTVHLRDVNDNAPKLAMVAPISITAGDQSES----------RLVTQVTATDNDEG---PNAVVTY 537
            |.:.:.||||.||....:|....:..:..|:          .:.|:|.....|.|   .|:.|:|
Mosquito  1045 LKILILDVNDCAPVFERIAIFRKSRCEMIENTSDLELMYLDEIETEVLPKFLDAGLMEMNSRVSY 1109

  Fly   538 ---SIYHVSNNG----------IQKFTINATTG-EIRTQGRLLAGEQYSITVQATDIGGLSSQAI 588
               |::.:..:.          .|...:|.|.. |..|..|.|    |...|:..   |.:::|:
Mosquito  1110 GVDSLFEMVQSAPYVGMPRLYDSQSVMVNRTADREHLTMRRKL----YKQKVRQR---GRNTRAV 1167

  Fly   589 VEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPE---NDAVVYSII------SGN 644
            .:.|..        :|..|       |..|:...:..:.|.|.:   |..|.|.::      ||.
Mosquito  1168 AKKSQL--------KFALP-------ENVEVGKVIFKLTANDDDFEKNSKVFYEVVGQTELNSGE 1217

  Fly   645 DLRQFAVGQESGVIIVIRKLDRESLTRYQLILKAEDTGGLSSSATVNIKVTDINDKNPEFEASTL 709
            .:..|.:.:.:|.:.|..:|..|  |..:|.:.|:|.||||....|..:|.|:||..|.||...
Mosquito  1218 RVSYFRIDRNNGELRVANRLPPE--TDVKLNITAKDVGGLSDMLQVQFRVYDVNDNAPVFEKQW- 1279

  Fly   710 PYVFQVEEGK---AQASVGVVHATDADEGINAEITYSIPTD----IPFTINATSGEILTAKELDY 767
             |.|.|:||.   ....:|.|.|.|.|.|:|..:||.:.||    |||:|:...|.|..:.|:|.
Mosquito  1280 -YTFNVDEGSYPITGKKIGQVRANDEDTGMNGNVTYMLITDGDQKIPFSISPLDGTIRVSGEIDR 1343

  Fly   768 EQLNEYKFVVTAKDGAPDARLGT-ASVTVMVLDLPDEVPKFSDARIDVHIPENEENFLVATVQAF 831
            |.:..|:|.|.|.|...|.:|.. ..|.|:|:|..|..|:|:                     |:
Mosquito  1344 EMIASYRFRVLASDNNFDLKLSAMVDVEVIVMDRNDNNPEFT---------------------AY 1387

  Fly   832 DPDSMPEITYVLRKGNAELFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTILLVV 896
            |                                  |..|
Mosquito  1388 D----------------------------------DLRS-------------------------- 1392

  Fly   897 DVEDRNDLP--PRFITVPDPVTVNDDQGIGTIIATLPAIDGDGTSPGN-VVRYEIVGRGKAPKYF 958
               |||::.  |.::...|   ||  ..:||.:..:.|.|.|....|| :|.|.:.|:....: |
Mosquito  1393 ---DRNNIKRLPVYVAYLD---VN--AKVGTFVKQVMARDSDFRENGNGLVIYSLTGQSDVLQ-F 1448

  Fly   959 QVDPDTGAVRIRDELRKEED------TEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIK 1017
            .:||..|.|....:....|.      ....|.:.|.|.|.|..||:|.|.|::       ..:..
Mosquito  1449 SIDPKDGVVTTASKFTPSEAGTRKTYEHLNVTVVASDFGTPPRSSMALLIVNL-------QGDTL 1506

  Fly  1018 LDNKLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFVSGN 1082
            ..:.:|....:        |....|...:.|:..|...  ::.:..||...:.|  ||.|.|...
Mosquito  1507 QQHPVEERPPL--------FPYKYYEIELRENDPAPRI--VLNVTLSKRYANDP--FRWEIVGDT 1559

  Fly  1083 GGGIFNLSSADHGCNLLLIQPLDFENKSSYSLQLRL-----------------------TSHRYF 1124
            ....|.:.  :...:|.|::|||.|.:.||.:::|:                       .|||.|
Mosquito  1560 FDDQFRID--ERNGSLWLLRPLDREERDSYDVRIRVQKIKRETRNIPSVLYALENPVKRKSHRLF 1622

  Fly  1125 VNPLKDTTSVEIIVQ--DENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGKF 1187
            .|      .|||:::  |.|||||.|     |.......:||.:..:....:::|.|||.|:|..
Mosquito  1623 DN------EVEIMIKVVDVNDNAPVF-----RDNYGPIISVVPDTANYGYAVMKVEATDDDAGSN 1676

  Fly  1188 GTVRYTLYDDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQGSHRTR 1252
            |.|||:|       :|.|...|.:...||.:|......:..:....|.|:|.|.:|.:.|. .|.
Mosquito  1677 GEVRYSL-------LNEPARLFAIDSLTGQIRLLNSLASFKEKVFGFDVKATDREGADDGK-STI 1733

  Fly  1253 ARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVSGIERMSSQKYLAKNGSVIEN 1317
            |.:.|..|.....:.|... ..|.|:......:...|...||....|      :.|..|..|.:
Mosquito  1734 ANVFVYVLHAHQEVCLILA-GLPVDIEKQLGMISSSLSTATGYDIRI------RALETNTKVDD- 1790

  Fly  1318 PAATDIWFYLIDPKTEQLVSRKDSIVETTLLEPAARSELNIALPRATAENI--SFPLERKEHVHK 1380
              ||:::.|.||.||       :.:||.|        ||..:|.|....|:  :.|:     :..
Mosquito  1791 --ATNLYLYAIDRKT-------NGLVEMT--------ELQRSLSRLDMSNLKPNLPI-----IEL 1833

  Fly  1381 VKAAVAIDNEVFPFTLIA-----ISLVILILGTIGIIY-------ICISWSKYK 1422
            .:.||   |.:.|.:..|     |.|..:::|  |:|:       :||:.::|:
Mosquito  1834 TELAV---NSIEPHSFDAAGMKGIELATVVIG--GLIFAGGTATALCIACARYR 1882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	25/117 (21%)
		Cadherin_repeat	146..259	CDD:206637	27/115 (23%)
		Cadherin_repeat	280..383	CDD:206637	32/271 (12%)
		Cadherin_repeat	393..496	CDD:206637	34/155 (22%)
		Cadherin_repeat	518..594	CDD:206637	20/92 (22%)
		Cadherin_repeat	608..699	CDD:206637	25/99 (25%)
		Cadherin_repeat	710..802	CDD:206637	36/99 (36%)
		Cadherin_repeat	814..903	CDD:206637	6/88 (7%)
		Cadherin_repeat	915..1005	CDD:206637	28/96 (29%)
		Cadherin_repeat	1041..1144	CDD:206637	30/127 (24%)
		Cadherin_repeat	1159..1264	CDD:206637	29/104 (28%)
Cad89D	XP_061499378.1	None