Protein Alignment Cad99C and Cad99C

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_061504016.1
• Gene: Cad99C / 1273658
• VectorBaseID: AGAMI1_000196
• Length: 1834
• Species: Anopheles gambiae
• Alignment Length: 1767
• Identity: 1065/1767 - (60%)
• Similarity: 1327/1767 - (75%)
• Gaps: 84/1767 - (4%)

  Fly     6 SLTPQQGLGFFGLLILLCSAVL----GKSQMCEVETGQTNIILDIEESRESFIGQPTTPPELPIF 66
            ::.|...|....:|::...|||    ||.|:|||||||::|||||||||.|.:.|.|.||||||.
Mosquito    86 TVRPAGSLLLLAILLVTSCAVLPGVEGKQQLCEVETGQSSIILDIEESRGSSVAQHTNPPELPIS 150

  Fly    67 GDPDTEIALNLVFPKGQPIFQLNGKKLQLLQPLDRDEENLSHIVFQVSCTTRSTGKKRTIPIIVR 131
            |||..:|.|.||||||:|.|.|:||.|:|:.|||||||||||||||::|..|||.:||.||||||
Mosquito   151 GDPTDDITLELVFPKGKPTFLLDGKSLRLIHPLDRDEENLSHIVFQITCMVRSTRRKRNIPIIVR 215

  Fly   132 VSDINDNAPRFMNTPYEVTVPESTPVGTTIFRNIQALDKDAGVNGLVEYFIAEGSPNSTNVEK-- 194
            |||:|||.|.|:|||||.||||||||||||||:|||.||||||||||||||.|||.|.:::..
Mosquito   216 VSDVNDNPPMFINTPYETTVPESTPVGTTIFRSIQATDKDAGVNGLVEYFIVEGSQNISDISPNT 280

  Fly   195 -YSADGYGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSN 258
             .:|||:|.|||::||||||||.||||:|:.|.||||||||||:||.::|||:|||||::||||:
Mosquito   281 LTAADGFGVFAIAYPHQGQVTVVKTLDYERTQRYYLTIVASDRSRNASERLSATTTLTIDIADSD 345

  Fly   259 DLDPSFIYSGCVSLDGACINPEYSASVPAGSLLGVLTVLPERIQAVDLDTINSPIRYSFASGMPG 323
            |.||||||.|||.|||||:|||||||||||:|.|||||.||||||||||||::||||||.||:||
Mosquito   346 DQDPSFIYRGCVLLDGACLNPEYSASVPAGTLQGVLTVTPERIQAVDLDTISAPIRYSFLSGIPG 410

  Fly   324 NYADYFQIDESTGVLKQTKAVDTS-TAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDANPPVI 387
            ||.|||:||..||||||||.||.| ||||:|::||||||| ..:|||||||.|.||||||.||:|
Mosquito   411 NYGDYFEIDPQTGVLKQTKLVDGSVTAKKFDLVVKAEEVS-DMKRFTTAKLSIHVKPVDAYPPMI 474

  Fly   388 SSSQAEGYVDENSPIGTRVLDAHGNPISFMTTDADLSDSDPKPDYIYELTTPSFNVTGDGILVVN 452
            |.:..||:|||||||||.|:||||:||...|||.||.......:||||:|||||.|:.:|:|.||
Mosquito   475 SITATEGFVDENSPIGTVVMDAHGSPIKLSTTDQDLGPDGEGMEYIYEVTTPSFTVSKEGVLRVN 539

  Fly   453 EENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLAMVAPISITAGDQSESR 517
            ||.||||||:||::.|||||||...||||||:||||||||||||||:||||||:::.|||  ..|
Mosquito   540 EEGLDRDPPSPGKYLFQVVAREASGNAASAPMSLTVHLRDVNDNAPRLAMVAPVTLMAGD--GRR 602

  Fly   518 LVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTGEIRTQGRLLAGEQYSITVQATDIGG 582
            |||||.|||||...||.:||||:||||||..||.|:..||||.|:.||.|||||||||||:|:||
Mosquito   603 LVTQVHATDNDAAENAAITYSIFHVSNNGASKFGIDPATGEIETRTRLNAGEQYSITVQASDVGG 667

  Fly   583 LSSQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPENDAVVYSIISGNDLR 647
            |||||||||::|||||||||||.:|:|||||||||||||||.|:.|||||||.|.|:|.:|||||
Mosquito   668 LSSQAIVEVTITPGPNTKPPRFARPVYEVQVSEGAEINSTVIVLKAEDPENDPVSYAITTGNDLR 732

  Fly   648 QFAVGQESGVIIVIRKLDRESLTRYQLILKAEDTGGLSSSATVNIKVTDINDKNPEFEASTLPYV 712
            ||::|::||||.||||||||.|||||||::|||.|||:|||||||||||||||||||:...||||
Mosquito   733 QFSIGKDSGVISVIRKLDREDLTRYQLIVRAEDNGGLASSATVNIKVTDINDKNPEFDERQLPYV 797

  Fly   713 FQVEEGKAQASVGVVHATDADEGINAEITYSIPTDIPFTINATSGEILTAKELDYEQLNEYKFVV 777
            |.|:||:...|:|.|.|||||||:||||||::|:||||.|::.:||:.|...||||:..||:|||
Mosquito   798 FAVDEGRENVSIGTVRATDADEGMNAEITYTVPSDIPFRIDSRTGEVRTKVALDYEKQKEYRFVV 862

  Fly   778 TAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENEENFLVATVQAFDPDSMPEITYV 842
            |||||||:.|||||||||.|.|:.||||:|.::.:::.:|||..:..|.||:|||||:.|||||.
Mosquito   863 TAKDGAPEPRLGTASVTVKVRDVADEVPRFMESTVEIKVPENVPDMTVTTVRAFDPDTKPEITYT 927

  Fly   843 LRKGNAELFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTILLVVDVEDRNDLPPR 907
            ||:|..:||||..::|:::||:|||||..|.|:|.:||:||:|.|.||.|.::|:||||||:||.
Mosquito   928 LRRGPGDLFKVDARTGQIKTIRGLDYEKDKMHELLVGTLENNGTGAGDYIRVLVEVEDRNDIPPV 992

  Fly   908 FITVPDPVTVNDDQGIGTIIATLPAIDGDGTSPGNVVRYEIVGRGKAPKYFQVDPDTGAVRIRDE 972
            |:::|:||::||:..||.|:.::||:||||:|||||||||:||||||.||||||.|:|.|||||:
Mosquito   993 FVSIPEPVSINDNLPIGAIVGSMPAVDGDGSSPGNVVRYELVGRGKALKYFQVDADSGIVRIRDD 1057

  Fly   973 LRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAF 1037
            |.||||:||.:|:||:|:||||||||:.|.|.|.|:.::.|.: ..:::||||..::.|..||||
Mosquito  1058 LGKEEDSEYLIDVRAFDMGEPQLSSVSTLPVYVGHIPANPNGD-SAESRLESGGIVNLEVQGLAF 1121

  Fly  1038 SDDSYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNG-GGIFNLSSADHGCNLLLI 1101
            ||||||||||||...|:|:|||||:|||.:......|.||....:. ..:|.::..||.|.|.|.
Mosquito  1122 SDDSYTTSVPESTGVNATIKLIQIINSKKATKHNGGFSCELAGDDTVRRLFRVTIEDHACALALA 1186

  Fly  1102 QPLDFENKSSYSLQLRLTSHRYFVNPLKDTTSVEIIVQDENDNAPEFEFNRLRGQ---QDTFYTV 1163
            .|||:|..:|:.|::||.|.:||||..::..:|::||||||||.|:|...|...|   .||:|.|
Mosquito  1187 APLDYEAATSHQLEVRLASSKYFVNQHRNAATVKVIVQDENDNVPQFVIPRTYQQSARNDTYYAV 1251

  Fly  1164 VTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDD--ENRV---NMPTSFFMMSEDTGVLRTAKH 1223
            :..:.|:||.:|||:|||||.|.:|.::|.|.|.|  .|.:   :.|:::|.:|||||:|:|.|.
Mosquito  1252 IGADADIDTPVLQVKATDRDMGPYGQLKYALLDVDGQANEIAPEDAPSTYFTVSEDTGMLKTQKP 1316

  Fly  1224 FKNENDFPLTFLVEARDSDGQEQGS---HRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTEL 1285
            .:.....||.|||||||::|.....   ||.|||:|||.:||||||||.|.::.|.|:|.:...|
Mosquito  1317 LQQVRQTPLVFLVEARDNNGNATAGAIVHRARARVVVNLIADINRMALVFLDSNPKDMRRHARNL 1381

  Fly  1286 EELLDKKT-GLVSGIERMSSQKYLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKDSIVETTLLE 1349
            ||||.:|| ||::||||.:.:|.|.:||:..|...|||:|||.:||:||:::.|..|.|...:..
Mosquito  1382 EELLHEKTDGLITGIERFAVRKVLNENGTAEEVAGATDVWFYAVDPQTERILERNSSTVAKRIFA 1446

  Fly  1350 PAARSELNI---ALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGI 1411
            ||..|::|.   ::.||||:.|..|:|.|..:.|:||.:..:.:||||.|||:::||||||:|||
Mosquito  1447 PAVLSQINFEASSIARATAQGIFGPIEPKLPIQKIKATIVGNEDVFPFALIAVAIVILILGSIGI 1511

  Fly  1412 IYICISWSKYKNFKQRMRQYS--STNPPRYDPVIVNQQASSASETIANMKEYETQMLAMAVP-PD 1473
            :|||||||||||||||||||:  :|:|.|||||::|.|....|:...::||||||:|||||| .|
Mosquito  1512 VYICISWSKYKNFKQRMRQYTAPATSPVRYDPVMINSQQQPPSDNPTSLKEYETQVLAMAVPLAD 1576

  Fly  1474 VDDDLQLDFSAKNHAFSLDNVSYITHKENTNGGGQSSPSHSDATTATIATLRRHKNLNNASMNNN 1538
            ..|||||||||||||||||||||||||||    ||.||::||||||.:.||:|:.| ||...|||
Mosquito  1577 EGDDLQLDFSAKNHAFSLDNVSYITHKEN----GQHSPTNSDATTAVVGTLQRNNN-NNTKNNNN 1636

  Fly  1539 LAINNRQNTFNRTLEMNTRNNANPLASPPNG--ALSGTLTLGRIKHQNSNHYQNGAYNIDPTGPN 1601
            |.|||||||.|||||||..|..|||.|..||  .:.|||||||||.:. |:|.|| |. |....|
Mosquito  1637 LNINNRQNTLNRTLEMNRNNYLNPLGSGGNGGPVVPGTLTLGRIKSER-NNYING-YG-DTLNRN 1698

  Fly  1602 NMAHAKNNAYSTMGRRGNTF-------------GDVGLLNG-------NG----------ELMNA 1636
            |:..|:||.::|:||.....             .:|.|..|       ||          |::..
Mosquito  1699 NLTMAQNNTFNTLGRNQRNINHAPHHNNANHGSNNVNLNQGHHHHPMHNGGPGVGGYAGTEIVTN 1763

  Fly  1637 TLGRNGQLNNRLYGGEVPITNPLFQ-RSNSD------HNHLSSTNENVSFGKRDYGQIGFSYLND 1694
            |||||.:.|      :||||||||. |.|.|      .||:|.||||||||||||.|:.||||||
Mosquito  1764 TLGRNNRYN------DVPITNPLFHIRQNGDLQSQPQLNHISPTNENVSFGKRDYNQLSFSYLND 1822

  Fly  1695 LDRSEVETTTEL 1706
            ||||:.||||||
Mosquito  1823 LDRSDAETTTEL 1834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204	50/71 (70%)
		Cadherin_repeat	146..259	CDD:206637	83/115 (72%)
		Cadherin_repeat	280..383	CDD:206637	80/103 (78%)
		Cadherin_repeat	393..496	CDD:206637	70/102 (69%)
		Cadherin_repeat	518..594	CDD:206637	55/75 (73%)
		Cadherin_repeat	608..699	CDD:206637	71/90 (79%)
		Cadherin_repeat	710..802	CDD:206637	59/91 (65%)
		Cadherin_repeat	814..903	CDD:206637	48/88 (55%)
		Cadherin_repeat	915..1005	CDD:206637	61/89 (69%)
		Cadherin_repeat	1041..1144	CDD:206637	48/103 (47%)
		Cadherin_repeat	1159..1264	CDD:206637	51/112 (46%)
Cad99C	XP_061504016.1	None