DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad99C and Pcdh15

DIOPT Version :9

Sequence 1:	NP_001189311.1	Gene:	Cad99C / 43528	FlyBaseID:	FBgn0039709	Length:	1706	Species:	Drosophila melanogaster
Sequence 2:	NP_075604.2	Gene:	Pcdh15 / 11994	MGIID:	1891428	Length:	1943	Species:	Mus musculus

Alignment Length:	1653	Identity:	473/1653 - (28%)
Similarity:	735/1653 - (44%)	Gaps:	276/1653 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CEVETG---QTNIILDIEESRESFI-----------GQPTTPPELPIFGDPDTEIALN------- 76
            |::..|   .|.:.:| ||||...|           |.|          ||..|::|.
Mouse    37 CKLARGGPPATIVAID-EESRNGTILVDNMLIKGTAGGP----------DPTIELSLKDNVDYWV 90

  Fly    77 LVFPKGQPIFQLNGKKLQLLQPLDRDEE-NLSHIVFQVSCTTRSTGK--KRTIPIIVRVSDINDN 138
            |:.|..|.:| ||...    :.||||.. |:..||.||.|..:..|.  ...:.|:||  |.|||
Mouse    91 LLDPVKQMLF-LNSTG----RVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVR--DRNDN 148

  Fly   139 APRFMNTPYEVTVPESTPVGTTIFRNIQ----ALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADG 199
            :|.|.:..|..||.|.||||||||....    |.|.|.|.||.:||.|.....:.|:.:
Mouse   149 SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPEDPTSND------ 207

  Fly   200 YGTFAISFPHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSF 264
              ||.|.....|.|.:.|.|::|....||:.|.|:|||:|..:|.::||||||::.|.:||.|.|
Mouse   208 --TFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF 270

  Fly   265 IYSGCVSLDGA--CINPEYSASVP---AGSLLGVLTVLPERIQAVDLD-TINSP-----IRYSFA 318
            :  .||.:...  |....|.|::|   ....|..:.|.|. |||:|.| .|..|     |.||..
Mouse   271 L--PCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPP-IQAIDQDRNIQPPSDRPGILYSIL 332

  Fly   319 SGMPGNYADYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGP-QRFTTAKLEIFVKPVDA 382
            .|.|.:|..:|.:...|..|...:.|:....:|:|:::|||:.:..| ..|.:..:||    :|.
Mouse   333 VGTPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEI----LDE 393

  Fly   383 N--PPVISSSQAEGYVDENSPIGTRVLDAHG--NPISFMTTDADLSDS-DPKPDYIYELTTPSFN 442
            |  .|..:....:||:.|::|:|..:.::..  .|:..:..|.|:.|: ||:........|..|.
Mouse   394 NNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 458

  Fly   443 VTGDGI--LVVNEENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLAMVAP 505
            ||..||  .:...:.:||:...  .:.|.:.|.:....  |.|:.:.:.:.|.|||.|....::.
Mouse   459 VTPTGITRYLTLLQPVDREEQQ--TYTFLITAFDGVQE--SEPVVVNIRVMDANDNTPTFPEISY 519

  Fly   506 ISITAGDQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTG--EIRTQGRLLAG 568
            ......|.|....|.|:||.|.|||.|..::|.|. |...|  .|.||.|||  .|.....|:.|
Mouse   520 DVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEIL-VGGKG--DFVINKTTGLVSIAPGVELIVG 581

  Fly   569 EQYSITVQATDIGGLS----SQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAE 629
            :.|::||||:|....:    |...|.:.|.|..|..||||.:.:|.::|||...|.:.:..:.|.
Mouse   582 QTYALTVQASDNAPPAERRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAILLNLQAT 646

  Fly   630 DPENDAVVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLILKAED--TGGLSSSATVNI 692
            |.|.|.:.|:|.:|:..|.|.:.:.:|::.:.:.|||||..||.||:.|.|  ..| :|:|||||
Mouse   647 DREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDG-TSTATVNI 710

  Fly   693 KVTDINDKNPEFEASTLPYVFQVEEGKAQASVGVVHATDADEGINAEITYSIPTDIPFTINATSG 757
            .|||:||..|.|: ..||....|.|.:|.|.||.|.|||.|.|||.::.||:..........::|
Mouse   711 VVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNG 774

  Fly   758 EILTAKELDYEQLNEYKFVVTAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPEN--- 819
            .|.||.:|:.|..:.|:.||.|.|||...|..|.::.:.|||:.|..|.|:::...|.:.||
Mouse   775 SIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPA 839

  Fly   820 EENFLVATVQAFDPDSMPEITYVLRKGNAE-LFKVSEKSGEVRTIKGLDYESQKQHQLTI----- 878
            ..:||  .::|.|.|....::|.:|....: ||.:...:||:..::.||||:....:.:|
Mouse   840 GTSFL--QIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 902

  Fly   879 -----GTIENDGNGPGDTILLVVDVEDRNDLPPRF-------ITVPDPVTVNDDQGIGTIIATLP 931
                 ||:.     ||...:.|: |:|.||.||.|       :..||.|.       ||.|.|:.
Mouse   903 AFDIYGTMP-----PGIATVTVI-VKDMNDYPPVFSKRIYKGMVAPDAVK-------GTPITTVY 954

  Fly   932 AIDGDGTS-PGNVVRYEI--VGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEP 993
            |.|.|... |.:.|||.:  |........|.|:.|:|.|..|..|.:|..|.:::.:.|:|.|||
Mouse   955 AEDADPPGMPASRVRYRVDDVQFPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEP 1019

  Fly   994 QLSSVAPLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTLKL 1058
            .:||.|.:|:.|.|     ..||.                  .|:.:.|.......:.|..|:..
Mouse  1020 VMSSSATVRILVLH-----PGEIP------------------RFTQEEYRPPPVSELAARGTVVG 1061

  Fly  1059 I--------QIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLIQPLDFENKSSYSLQ 1115
            :        .||.|..:|:....|          ||.|::..     :.:..|||:|.::||.|:
Mouse  1062 VISAAAINQSIVYSIVAGNEEDKF----------GINNVTGV-----IYVNSPLDYETRTSYVLR 1111

  Fly  1116 LRLTSHRYFVNPLK-----DTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYT-VVTEEMDVDTTI 1174
            ::..|....:..|:     :|..|.|.:|||||:.|.|        |..||. .|:|:..:..::
Mouse  1112 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVF--------QKKFYIGGVSEDARMFASV 1168

  Fly  1175 LQVRATDRDSGKFGTVRYTLYDDDENRVNMP-----TSFFMMSEDTGVLRTAKHFKNENDFPLTF 1234
            |:|:|||||:|.:..:.|        |:.:|     ...|::...||:::||..|.|.......|
Mouse  1169 LRVKATDRDTGNYSAMAY--------RLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1225

  Fly  1235 LVEARDSDGQEQGSHRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKT-----G 1294
            .|.|.|..|:...........|||:|    .|.:...|..|:.:.....:|.|:||:..     |
Mouse  1226 QVIATDDYGKGLSGKADVLVSVVNQL----DMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPG 1286

  Fly  1295 LVSGIERMSSQKYLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKD--SIVETTLLE-----PAA 1352
            ....:|.:.::::  .:...:|:.:..|:..|.|||:|.:.:.|.:  ..::..||:     ...
Mouse  1287 AKVVVESIGARRH--GDAYSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPY 1349

  Fly  1353 RSELNIALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYICIS 1417
            ..|....|...|.|.::...:|.|.:...:.|           |:|::.:|::.....|:.:.:|
Mouse  1350 YGEGGRILEIRTPEAVTSIKKRGESLGYTEGA-----------LLALAFIIILCCIPAILVVLVS 1403

  Fly  1418 WSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASETIANMKEYETQMLAMAVPPDVDDD----- 1477
               |:.||  :||...|...|.      |.|..|::..|.:.      .|.|.||.....
Mouse  1404 ---YRQFK--VRQAECTKTARI------QSAMPAAKPAAPVP------AAPAPPPPPPPPPPGAH 1451

  Fly  1478 --LQLDFSAKNHAFSLDNVSYITHKENTNGGG---QSSPSHSDATTATIATLRRHKNLNNASMNN 1537
              .:|..||.::.|.|      .|.|.:.|..   :...||.|....:.:|...|:   .|.:..
Mouse  1452 LYEELGESAMHNLFLL------YHFEQSRGNNSVPEDRSSHRDGMAFSSSTTESHE---PAHVEG 1507

  Fly  1538 NLAIN--NRQNTFNRTLEMNTRNNANPL 1563
            .|..:  |...||:...:.:..:..|||
Mouse  1508 PLKESQPNPARTFSFVPDEDNLSTHNPL 1535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_001189311.1	Cadherin_repeat	<68..138	CDD:206637	26/79 (33%)
		Cadherin_repeat	146..259	CDD:206637	46/116 (40%)
		Cadherin_repeat	280..383	CDD:206637	33/112 (29%)
		Cadherin_repeat	393..496	CDD:206637	25/107 (23%)
		Cadherin_repeat	518..594	CDD:206637	30/81 (37%)
		Cadherin_repeat	608..699	CDD:206637	36/92 (39%)
		Cadherin_repeat	710..802	CDD:206637	35/91 (38%)
		Cadherin_repeat	814..903	CDD:206637	26/102 (25%)
		Cadherin_repeat	915..1005	CDD:206637	31/92 (34%)
		Cadherin_repeat	1041..1144	CDD:206637	27/115 (23%)
		Cadherin_repeat	1159..1264	CDD:206637	31/110 (28%)
Pcdh15	NP_075604.2	Cadherin_repeat	156..245	CDD:206637	37/96 (39%)
		Cadherin_repeat	286..394	CDD:206637	33/112 (29%)
		Cadherin_repeat	404..510	CDD:206637	25/109 (23%)
		Cadherin_repeat	518..614	CDD:206637	34/98 (35%)
		Cadherin_repeat	626..718	CDD:206637	37/92 (40%)
		Cadherin_repeat	727..820	CDD:206637	35/92 (38%)
		Cadherin_repeat	828..926	CDD:206637	26/105 (25%)
		Cadherin_repeat	935..1032	CDD:206637	33/103 (32%)
		Cadherin_repeat	1050..1145	CDD:206637	26/109 (24%)
		Cadherin_repeat	1154..1248	CDD:206637	26/101 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1425..1453		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1475..1533		11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1714..1865
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23401
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1610
Isobase	1	0.950	-	0	Normalized mean entropy	S7525
OMA	1	1.010	-	-		QHG47650
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005384
OrthoInspector	1	1.000	-	-		oto93776
orthoMCL	1	0.900	-	-		OOG6_109439
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.820