Protein Alignment Cad99C and Pcdhb15

DIOPT Version :10

• Sequence 1: NP_733314.1
• Gene: Cad99C / 43528
• FlyBaseID: FBgn0039709
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: NP_001419531.1
• Gene: Pcdhb15 / 108348201
• RGDID: 11368541
• Length: 800
• Species: Rattus norvegicus
• Alignment Length: 707
• Identity: 180/707 - (25%)
• Similarity: 309/707 - (43%)
• Gaps: 133/707 - (18%)

  Fly   423 LSDSDPKPDYIYELTTPSFNVTGDGILVVNEENLDRD----PPAPGRFKFQVVAREPRTNAASAP 483
            :||.:.:    :.|.:|   :||:  |::||: |||:    |..|....||::...|.....:|
  Rat    81 VSDQNTR----FLLLSP---LTGE--LILNEK-LDREELCGPTEPCVLTFQLLLERPFQIYRAA- 134

  Fly   484 LSLTVHLRDVNDNAPKLAMVAPISITAGDQSESRLVTQVT----------ATDNDEGPNAVVTYS 538
                :|::|:|||:|...          |:.....:::.|          |.|:|.|.|::..|:
  Rat   135 ----LHVKDINDNSPVFL----------DKEIHLKISESTTPGATFFLERAQDSDVGTNSLSNYT 185

  Fly   539 I-------YHVSNNGIQKFTINATTGEIRTQ---GRLLAGE---QYSITVQATDIGG--LSSQAI 588
            |       .||::.|         .|.|..:   .::|..|   ::::|:.|.|.|.  .|..|:
  Rat   186 ISPNDYFHIHVNDGG---------EGTIFPELVLDKMLDREEIPEFTLTLTALDGGSPPRSGTAL 241

  Fly   589 VEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPE---NDAVVYSIISGND--LRQ 648
            |.:.|. ..|...|:|.:.:|:||..|...:.|.|..|.|.|.:   |..:.|:.....:  |:.
  Rat   242 VRILVL-DINDNSPQFVQSLYKVQSPEDTPVGSLVVAVSARDLDTGSNGQITYTFSYATERILQT 305

  Fly   649 FAVGQESGVIIVIRKLDRESLTRYQLILKAEDTGGLSSSATVNIKVTDINDKNPEFEASTL--PY 711
            |.:...||.:.:.|:|:.|::..|.:.::|.|.||||...||.::|.|:||..|||..|:|  |
  Rat   306 FQINSTSGNLYLKRELNYEAIQTYSITIQARDGGGLSGKCTVVVEVMDVNDNPPEFLLSSLNSP- 369

  Fly   712 VFQVEEGKAQASVGVVHATDADEGINAEITYSIPTDIPFTINATSGE---ILTAKELDYEQLNEY 773
               :.|...:|.|.|....|.|.|.|.:...|:..|:||.:..:...   ::|.|.||.|...||
  Rat   370 ---IPENSPEAVVAVFRIRDRDSGNNGKTMCSVAHDLPFVLKPSVENFYTLVTEKPLDREAYTEY 431

  Fly   774 KFVVTAKD-GAPDARLGTA-SVTVMVLDLPDEVPKFSDARIDVHIPENEENFL-VATVQAFDPD- 834
            ...:|..| |.|  ||.|. ::||.|.|:.|..|.|:.....:.:.||....| :.|:.|.|.|
  Rat   432 NITITVSDLGTP--RLTTQHTITVQVSDINDNAPTFTQTSYTMFVRENNSPALHIGTISATDSDS 494

  Fly   835 -SMPEITYVL------RKGNAELFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTI 892
             |...|||.|      :.....|..::..:|::..|:.||:|..:..:..:|..:..........
  Rat   495 GSNAHITYSLLPPHDPQLALDSLISINADNGQLFAIRALDFEDLQAFEFHVGAEDQGSPALSSQA 559

  Fly   893 LLVVDVEDRNDLPPRFITVP----------------DPVTVNDDQGIGTIIATLPAIDGDGTSPG 941
            |:.|.|.|.||..| |:..|                :|         |.::..:.|:|.|  |..
  Rat   560 LVRVVVLDDNDNAP-FVLYPLQNASTPCTELLPRAAEP---------GYLVTKVVAVDRD--SGQ 612

  Fly   942 NV-VRYEIVGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDV 1005
            |. :.:::: :...|..|.|....|.||....|.:.:..::::.:...|.|||..|:    .|.:
  Rat   613 NAWLSFQLL-KATEPGLFSVWSHNGEVRTTRMLGERDVPKHKLLLVVKDNGEPPRSA----SVTL 672

  Fly  1006 HHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSYTTSVPESMEANSTLKLIQIV 1062
            |.||..|.::..|.        :...:...|..:|:.|..:..::.:.|:|.|:.::
  Rat   673 HVLLVDGFSQPYLP--------LPEMAHDPAQEEDALTLYLVIALASVSSLFLVSVL 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad99C	NP_733314.1	CA_like	68..140	CDD:481204
		Cadherin_repeat	146..259	CDD:206637
		Cadherin_repeat	280..383	CDD:206637
		Cadherin_repeat	393..496	CDD:206637	21/76 (28%)
		Cadherin_repeat	518..594	CDD:206637	22/100 (22%)
		Cadherin_repeat	608..699	CDD:206637	29/95 (31%)
		Cadherin_repeat	710..802	CDD:206637	31/96 (32%)
		Cadherin_repeat	814..903	CDD:206637	23/97 (24%)
		Cadherin_repeat	915..1005	CDD:206637	19/90 (21%)
		Cadherin_repeat	1041..1144	CDD:206637	4/22 (18%)
		Cadherin_repeat	1159..1264	CDD:206637
Pcdhb15	NP_001419531.1	Cadherin_2	44..125	CDD:462413	16/53 (30%)
		Cadherin_repeat	151..252	CDD:206637	24/110 (22%)
		Cadherin_repeat	261..357	CDD:206637	30/95 (32%)
		Cadherin_repeat	370..461	CDD:206637	30/92 (33%)
		Cadherin_repeat	469..571	CDD:206637	24/101 (24%)
		Cadherin_repeat	590..678	CDD:206637	23/103 (22%)
		Cadherin_C_2	701..784	CDD:465139	4/21 (19%)