DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad99C and pcdh15

DIOPT Version :9

Sequence 1:NP_001189311.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster
Sequence 2:XP_031761776.1 Gene:pcdh15 / 100494111 XenbaseID:XB-GENE-986760 Length:1715 Species:Xenopus tropicalis


Alignment Length:1753 Identity:489/1753 - (27%)
Similarity:793/1753 - (45%) Gaps:301/1753 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 CEVETG---QTNIILDIEESRESFI----------GQPTTPPELPIFGDPDTEIALNLVFPKGQP 84
            |::..|   .|.:.:|.|.:..:.|          |.|....||.:..:.|..:.|.   ||.|.
 Frog    35 CKLARGGIPATIVPIDEESANGTIIVDNMQIKGTAGVPDATIELSLKDNTDYWVILE---PKTQR 96

  Fly    85 IFQLNGKKLQLLQPLDRD-EENLSHIVFQVSCTTRSTGK--KRTIPIIVRVSDINDNAPRFMNTP 146
            :: ||...    :.|||| ..::..||..|.|..:..|.  ...:.|:||  |.|||:|:|....
 Frog    97 LY-LNSTG----RVLDRDPPSSIQSIVVLVQCVNKKVGSIINHEVRIVVR--DKNDNSPKFQMQN 154

  Fly   147 YEVTVPESTPVGTTIFRNIQ----ALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISF 207
            |...|.|.||||||||....    |.|.|.|.||.:||.| :.:||.|...:       ||.|..
 Frog   155 YRAVVNELTPVGTTIFTGFSGDGGATDIDDGPNGQIEYVI-QYNPNDTASNQ-------TFDIPL 211

  Fly   208 PHQGQVTVAKTLDFEKIQTYYLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFIYSGCVSL 272
            ...|.|.:.:.|::|:...|::.:.|:||..|..:|.:|||||||:|.|.:||.|.|:  .||.:
 Frog   212 TLSGAVVLRRRLNYEEKTRYFVIVQANDRTPNPNERRTSTTTLTVDILDGDDLGPMFL--PCVLV 274

  Fly   273 DGA--CINPEYSASVP---AGSLLGVLTVLPERIQAVDLDTINSP------IRYSFASGMPGNYA 326
            |..  |....|:|.:|   :.:.:..:.|.| .|||:|.|....|      |.||...|.|.|||
 Frog   275 DKTRDCRPLTYNAVIPELRSPAAVNPVNVTP-AIQAIDQDRDIQPASDRPGIIYSILIGTPQNYA 338

  Fly   327 DYFQIDESTGVLKQTKAVDTSTAKKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDANPPVISSSQ 391
            :||.::::|.||:..|.|:....:|:|:::|||:.:..|.. ..|.|.|.:...:...|..:...
 Frog   339 EYFSMNQTTAVLRLLKPVNRDLIQKFDLVIKAEQDNGHPLP-AFANLHIDILDENNQAPYFTFVT 402

  Fly   392 AEGYVDENSPIGTRVLDAHG--NPISFMTTDADLSDSDPKPDYIY-ELTTPSFNVTGDGI--LVV 451
            .:||:.|:||:||.:.|:..  .|:.|:..|.|:.::.....|:| ...:..|:||..||  .:.
 Frog   403 YQGYILESSPVGTTISDSQNLTAPLKFVALDNDIEETKDPQLYLYLNAFSTVFSVTPTGITRYLT 467

  Fly   452 NEENLDRDPPAPGRFKFQVVAREPRTNAASAPLSLTVHLRDVNDNAPKLAMVA-----PISITAG 511
            ..:.:||:  ....::|.::|.:  ....|.|:::.:.:.|.|||.|..:.::     ...:.||
 Frog   468 LLQPVDRE--TQQIYQFSMIASD--GTQESFPVTVNIIVIDANDNTPTFSNISYNVKIYTDVKAG 528

  Fly   512 DQSESRLVTQVTATDNDEGPNAVVTYSIYHVSNNGIQKFTINATTG--EIRTQGRLLAGEQYSIT 574
            :.     :.::||.|.|||.|..:||.|...|..   ||.||..||  .|.....:|.||.:::|
 Frog   529 ES-----IIRLTALDADEGVNGQITYEILAGSQG---KFEINGRTGVVSISPGVTVLVGEMFALT 585

  Fly   575 VQATDIGGL----SSQAIVEVSVTPGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPENDA 635
            |:|.|...|    ||...|.:.|.|..|..||||.:.:|.::|||...|.:.:..:.|.|.|.|.
 Frog   586 VKAYDNAPLNQRRSSITTVYIEVLPPNNQSPPRFSQLMYSLEVSEAMRIGAILLNLQATDREGDP 650

  Fly   636 VVYSIISGNDLRQFAVGQESGVIIVIRKLDRESLTRYQLILKAED--TGGLSSSATVNIKVTDIN 698
            :.|.|.:|:..:.|.:...||::::.:.|||||..||.||:.|.|  ..| :|:||||:.|||:|
 Frog   651 ITYLIENGDPQKVFNLSVSSGLLMLAKALDRESTDRYILIVTASDGRADG-TSTATVNVVVTDVN 714

  Fly   699 DKNPEFEASTLPYVFQVEEGKAQASVGVVHATDADEGINAEITYSIPT-DIPFTINATSGEILTA 762
            |.:|.|:. .||....|:|.:..|.||.|.|||.|.|:|.::.||:.. :..|.|.| :|.|.|:
 Frog   715 DNDPVFDL-YLPRNLSVQEEELNAFVGQVRATDPDAGVNGQVRYSLANLNNIFRITA-NGSIYTS 777

  Fly   763 KELDYEQLNEYKFVVTAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENE-ENFLVA 826
            .:||.|..:.|:.||.|.|||.|.|..|.::|:.|:|:.|..|:|:::...|.:|||. ...:..
 Frog   778 VKLDRETKDSYELVVEATDGAVDPRRSTITLTIKVIDIDDNSPQFTNSTYSVSVPENMIPGTVFL 842

  Fly   827 TVQAFDPDSMPEITYVLRKGNA-ELFKVSEKSGEVRTIKGLDYE----SQKQHQLTIGTIENDGN 886
            .|||.|.|....|||.:|..:. :.|.:::.:||:..:|.||||    .:..:...|...:..|.
 Frog   843 RVQAKDADLGANITYRIRSQDVLQFFAMNQSTGELSLLKALDYELFTNMEAAYMFIIEAFDAAGT 907

  Fly   887 GPGDTILLVVDVEDRNDLPPRF-------ITVPDPVTVNDDQGIGTIIATLPAIDGD--GTSPGN 942
            .|.....:.|.|:|.||..|.|       :..||.:.       ||::||:.|.|.|  || |.:
 Frog   908 MPPGLATVTVRVKDMNDYSPVFTKALYWGMVAPDALK-------GTLVATVAAEDKDPPGT-PAS 964

  Fly   943 VVRY--EIVGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDV 1005
            .|||  ::|....:...|.|:.:||.|..|..|.:|..|.:::.:.|||.|:|..|:...:.:.|
 Frog   965 KVRYKVDVVQFPYSASIFDVEENTGRVLTRVNLNEEPSTIFRLGVIAYDDGDPVKSNSTTVIITV 1029

  Fly  1006 HHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDDSY-TTSVPESMEANSTLKLI-------QIV 1062
                                   ...|:...|:.|.| ...|.|.....||:.::       .||
 Frog  1030 -----------------------LQPSVIPRFTQDEYRPPPVSELAPLGSTVTVVLAAALNQTIV 1071

  Fly  1063 NSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLI-QPLDFENKSSYSLQLR-----LTSH 1121
            .|             .:|||..|||   :.|:...::.: :|||:||.:||.|:::     :|.:
 Frog  1072 YS-------------IISGNDQGIF---AIDNSTGVITVAKPLDYENTTSYELRIQADSMEVTKY 1120

  Fly  1122 RYFVNPLKDTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGK 1186
            ........:|..|.|.||||||:||.|       .:..:...|:|:..:..::|:|:.||||:|.
 Frog  1121 NLRAASKSNTAIVFIEVQDENDHAPVF-------SKKVYLGGVSEDARMFASVLKVKTTDRDTGN 1178

  Fly  1187 FGTVRYTLY-----DDDENRVNMPTSFFMMSEDTGVLRTAKHFKNENDFPLTFLVEARDSDGQEQ 1246
            |.|..|.|.     |..|.        |::...:|:::||..|||.......|.|.|.|..|:..
 Frog  1179 FSTNNYKLVIPPIKDSKEG--------FVIEIHSGIIKTAMLFKNMRRSYFKFDVIATDDYGKGL 1235

  Fly  1247 GSHRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELL-----DKKTGLVSGIERMSSQK 1306
            .|   :|.::|:.:..:: |.:...|..|:.:.....:|..:|     |:..|....:|.:.:::
 Frog  1236 SS---KAEVIVSVVNQLD-MQVIVSNVPPTVIEENIDDLVRILEGYVQDQIPGAAVVVESIGARR 1296

  Fly  1307 YLAKNGSVIENPAATDIWFYLIDPKTEQLVSRKD--SIVETTLLEPAARSE---------LNIAL 1360
            |  .:|...|:...:|:..|.:||||.:.:||.:  ..::..:|:...:.:         |.|..
 Frog  1297 Y--GDGFSQEDYTQSDLMIYAVDPKTNRAISRNELYKFLDGKVLDINKQFQDYIGQGGRILEIRT 1359

  Fly  1361 PRATAENISFPLERKEHVHKVKAAVAIDNEVFPFTLIAISLVILILGTIGIIYICISWSKYKNFK 1425
            |...|           :|.|...||.....    .|:|::::|::.....|:.:.:|   |:.||
 Frog  1360 PDVVA-----------NVKKQAQAVGYTEG----ALLALAIIIILCCIPAIMIVMVS---YRQFK 1406

  Fly  1426 QRMRQYSSTNPPRYDPVI-VNQQASSASETI------ANMKEYETQMLAMAVPPDV--DDDLQL- 1480
            .|..:.:.|  .|....: ..:|::.|:..:      :.|:.|..|.....:.|.:  .::|.: 
 Frog  1407 DRQAECAKT--ARIQMALPAGKQSTPAANNLYEELGGSTMRGYAHQEQQQLLRPSLLKPEELSME 1469

  Fly  1481 ------------DFSAKNHAFSLDNVS-----------YITHKE--NTNGGGQSSPSHSDATTAT 1520
                        |:.:..|.:.|....           |..:.|  ..|.||.....|...|...
 Frog  1470 SGIDPGQEYYGQDYYSYEHGYELPQYGSRRRLLSPAGMYEDYGEVVMENDGGYYYTPHGPGTEGD 1534

  Fly  1521 IATLRRHK-----NLNNASMNNNLAINNRQNTFNRTLEMNTRNNAN-PLASPPNGA--------- 1570
            ||..:|.|     ....:|.....|..::    ||....|.:||.| .:....||:         
 Frog  1535 IAKNKRIKLVVDREYETSSTGEESAPESK----NRLSHPNIQNNVNGNIYIAQNGSVIRTRRSCL 1595

  Fly  1571 -----LSGTLTLGR---------IKHQNS---NHYQNGAYNIDPTGPNNMAHAKNNAYSTMGR 1616
                 :|..|.||:         :.|:.:   |....||.....:.|:.::.|.|||   ||:
 Frog  1596 TNNLKISSPLRLGKQFKKLDKLGVTHEENIQLNTLSKGASIKLNSKPSCISLASNNA---MGK 1655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad99CNP_001189311.1 Cadherin_repeat <68..138 CDD:206637 21/72 (29%)
Cadherin_repeat 146..259 CDD:206637 45/116 (39%)
Cadherin_repeat 280..383 CDD:206637 35/111 (32%)
Cadherin_repeat 393..496 CDD:206637 27/107 (25%)
Cadherin_repeat 518..594 CDD:206637 29/81 (36%)
Cadherin_repeat 608..699 CDD:206637 35/92 (38%)
Cadherin_repeat 710..802 CDD:206637 37/92 (40%)
Cadherin_repeat 814..903 CDD:206637 27/94 (29%)
Cadherin_repeat 915..1005 CDD:206637 29/93 (31%)
Cadherin_repeat 1041..1144 CDD:206637 32/116 (28%)
Cadherin_repeat 1159..1264 CDD:206637 30/109 (28%)
pcdh15XP_031761776.1 ECD 34..143 CDD:408229 29/117 (25%)
Cadherin_repeat 155..263 CDD:206637 45/115 (39%)
CA 308..396 CDD:214520 29/88 (33%)
Cadherin_repeat 402..508 CDD:206637 27/109 (25%)
Cadherin_repeat 516..612 CDD:206637 33/103 (32%)
Cadherin_repeat 624..>696 CDD:206637 25/71 (35%)
Cadherin_repeat 725..818 CDD:206637 37/93 (40%)
Cadherin_repeat 826..924 CDD:206637 27/97 (28%)
Cadherin_repeat 934..1030 CDD:206637 32/126 (25%)
Cadherin_repeat 1048..1143 CDD:206637 31/110 (28%)
Cadherin_repeat 1156..1246 CDD:206637 30/100 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 65 1.000 Domainoid score I9922
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H23401
Inparanoid 1 1.050 491 1.000 Inparanoid score I1379
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15091at33208
OrthoFinder 1 1.000 - - FOG0005384
OrthoInspector 1 1.000 - - oto104004
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5325
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
88.090

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