DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad99C and si:dkey-22o22.2

DIOPT Version :10

Sequence 1:NP_733314.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster
Sequence 2:XP_001921123.3 Gene:si:dkey-22o22.2 / 100149950 ZFINID:ZDB-GENE-100922-84 Length:2780 Species:Danio rerio


Alignment Length:1812 Identity:419/1812 - (23%)
Similarity:702/1812 - (38%) Gaps:386/1812 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 TNIILDIEESRESFIGQPTTPPELPIFGDPDTEIALNLVFPKGQPIFQLNGKK--LQLLQPLDRD 102
            ||....|.....|.:||.....:...|........| ||.|..  :|.:|.:.  |.|.:.:|.:
Zfish   352 TNTTYTIHIPESSAVGQAVAVVQAISFQRKTLSYML-LVNPSN--LFSINQESGALSLTRTVDYE 413

  Fly   103 E-ENLSHIVFQVSCTTRSTGKKRTIPIIVRVSDINDNAPRFMNTPY-EVTVPESTPVGTTIFRNI 165
            . ::|.|:  ||..:...||......::|.::|.||..|.||::.| ...|||:||.||::.: :
Zfish   414 SGQHLHHL--QVRASEPDTGLSNMAEVVVHITDENDCTPEFMHSIYSRDNVPETTPTGTSLLQ-V 475

  Fly   166 QALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEK-IQTYYL 229
            .|.|.|.|:|..:.|||            .|.|    |.|:  .||.|:.::.||:|: ...|..
Zfish   476 LARDCDTGLNAELSYFI------------QSVD----FDIT--SQGVVSPSQRLDYERPNHMYEC 522

  Fly   230 TIVASDRARNTADRLSSTTTLTVNIADSNDLDPSF---IYSGCVSLDGACINPEYSASVPAGSLL 291
            |:||.|  :.|..| :.|.::.:.:|:.||..|.|   ||...:|.|.   .||...::      
Zfish   523 TVVAVD--KGTPPR-TGTASIRIRMANVNDEAPVFSQTIYKTFLSEDA---GPETLVAI------ 575

  Fly   292 GVLTVLPERIQAVDLDTINSPIRYSFASGMPGNYADYFQIDESTGVLKQTKAVDTS-TAKKYDII 355
                     :.|.|.|  ...:.|:...   ||....|::|...|::|..::.... ...:|.:.
Zfish   576 ---------VHAKDPD--GDGVTYAITG---GNEDSNFELDNQKGIIKLRRSPPPRLRGPQYVLN 626

  Fly   356 VKA--EEVSPGPQRFTT-AKLEIFVKPVDANPPVIS---SSQAEGYVDENSPIGTRVL--DAHGN 412
            |.|  :..:.|....:: |::.:.:..::.|.||..   :......|.||.|.||.||  .||  
Zfish   627 VTATDDNAAGGALPLSSCAQVIVGINDINNNKPVFDECHNYSVNALVLENQPPGTFVLRVQAH-- 689

  Fly   413 PISFMTTDADLSDSDPKPDYIYEL--TTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQVVAREP 475
                   |||...:......|.:.  .:|.|.:..|..::....:.||:...  .:...|.|   
Zfish   690 -------DADTGVNGEVKYGIMQRDGASPGFTINPDTGVISTAVSFDREKQR--EYTLSVTA--- 742

  Fly   476 RTNAASAPL----SLTVHLRDVNDNAPKLAMVAPISITAGDQSESRLVTQVTATDNDEGPNAVVT 536
             |:.|..||    .:||.:.|.|||.||............|........:..|.|:|:|.|:.:|
Zfish   743 -TDQAQEPLIGICQITVLIADQNDNDPKFENSRYQYFLREDTPVGTSFLRAAAHDDDQGTNSAIT 806

  Fly   537 YSIYHVSNNGIQKFTINATTGEIRTQGRLLAGEQYSITVQATDIGGLSSQAIVEVSVTPGPNTKP 601
            ||:   |......|.||.:||.|.....:....:.|..:.|||.|..||...:.|.:| ..:.:|
Zfish   807 YSL---SQQNPAYFHINPSTGWIYVNQPISQTSRISQQIIATDGGSRSSSVDLTVIIT-NVHNQP 867

  Fly   602 PRFQKPIYEVQVSEGAEINSTVTVVHAEDPEND-AVVYSIISG-----NDLRQFAVGQE----SG 656
            |::::..|.|.:.|....::.:..:.|..|..| .|.|::..|     |...:|.:...    |.
Zfish   868 PQWEQAEYWVTIPENTPRDTKIVTIKATSPLGDPRVTYNLEEGQVPETNMPVRFYIKPNRRDGSA 932

  Fly   657 VIIVIRKLDRESLTRYQLILKAEDTGG--LSSSATVNIKVTDINDKNPEFEASTLPYVFQVEEG- 718
            .|:|...||.|:...:.|.::.::...  |:|..||.:.:||:||..|.|.:||  |...|.|| 
Zfish   933 SILVAENLDYETTGFFTLRVRVQNVAAVPLASFTTVYVNITDVNDNVPFFMSST--YEATVPEGA 995

  Fly   719 KAQASVGVVHATDADEGINAEITYSIPTDIP-----FTINATSGEILTAKELDYEQLNEYKFVVT 778
            :...||..|.|||.|.|::..|.|.|..|..     |:||:.:|.|.|....|.||...|...|.
Zfish   996 EIGTSVAQVSATDLDSGLHGMINYIILKDQSGDSQFFSINSYTGIIHTRATFDREQKGSYLIEVQ 1060

  Fly   779 AKDGAPDARLG--------TASVTVMVLDLPDEVPKFSDARIDVHIPENEE-NFLVATVQAFDPD 834
            ::|.:..||.|        ||.|.|.|.|:.|..|.||....::.:.|::| .|:|.||.|.|.|
Zfish  1061 SQDSSESARPGQQGQPNTDTAYVRVFVTDVNDNAPAFSQPVYEISVEEDKEVGFVVITVTANDED 1125

  Fly   835 --SMPEITYVLRKGNA-ELFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTILLVV 896
              :..::.|.:..||. ..|.|..:.|.:...:.||||..::::|.:  :.:||.....| ::|:
Zfish  1126 EGANAKLRYQITSGNTMGTFDVEPEVGTIFIAQRLDYEQVQRYELRL--VASDGKWENQT-MVVI 1187

  Fly   897 DVEDRNDLPPRFITVPDPVTVNDD-QGIGTIIATLPAIDGDGTSPGNVVRYEIVGRGKAPKYFQV 960
            :|.::||..|.|.......:|.:: ..:..::..:.|.|.|..:....|||.:.|:| |...|.:
Zfish  1188 NVINQNDEAPLFTQTEYHASVMEELTELPVLVLEVSATDPDQEADQRAVRYSLHGQG-AGSEFTI 1251

  Fly   961 DPDTGAVRIRDELRKEEDTEYQVDIRAYDLGEPQLSSVAPLRVDVHHLLSSGNNEIKLDNKLESG 1025
            |...|.:..:..|.:|..:.:|..:.|.|.....|:..|.:.|||..:     |:          
Zfish  1252 DEINGRIFAQRRLDREVRSAWQFLVLATDENGAGLTGFADVLVDVQDI-----ND---------- 1301

  Fly  1026 TGMSSESIGLAFSDDSYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNGGGIFNLS 1090
                :..:.|..:|:.:...|||:..|::::..::..:......|..|.....:..|.....|| 
Zfish  1302 ----NAPVFLCATDNCFLGHVPENSPADTSIMEMRATDLDDPKAGKNAILTYRIVQNVRNEINL- 1361

  Fly  1091 SADHGCNLLLIQPLDFENKSSYSLQLRLTSH---RYFV-------NPLKDTTSVEIIVQDENDNA 1145
                  ||..|.|   ...:.|::...|...   ||.|       ..|..|.:..|::.|.||:.
Zfish  1362 ------NLFSINP---TTGTIYTVLRSLDREVVDRYLVVVEARDGGGLSGTGTATIVISDVNDHP 1417

  Fly  1146 PEFEFNRLRGQQDTFYTVVTEEMDVDTTILQVRATDRDSGKFGTVRYTLYDDDENRVNMPTSFFM 1210
            |.|       .|..:...::|.:|:::.::.|.|||.|.|:...:.:::...||:|     .||:
Zfish  1418 PVF-------TQRVYMASMSENLDINSEVMVVAATDGDEGENSVMTFSIIGGDEDR-----KFFI 1470

  Fly  1211 MSEDT---GVLRTAKHFKNENDFPLTF-----------------LVEARDSDGQ---------EQ 1246
            .::..   |::|..|....|.....||                 :::..||:..         |.
Zfish  1471 ETDKVNRRGIVRLKKKIDFEKPHERTFNLTVKVEDADFFSLAYCIIQVEDSNDHTPVFFPQFYEA 1535

  Fly  1247 GS-------HRTRARIVVNKLADINRMALSFPNAAPSDLRNYYTELEELLDKKTGLVSGIERMSS 1304
            ||       ....|::....|........::..|..||      ..::.|..|:|.|...:.:..
Zfish  1536 GSMFEDVPVGTIVAQVTAMDLDSGQNGRFTYSIAPESD------PFQQFLVDKSGWVVVADSLDR 1594

  Fly  1305 QKY-----------------------------LAKNGSVIENPAATDIWFYLIDPKTEQLVSRKD 1340
            :|.                             :..||...|.|....:|...|.|   |::...|
Zfish  1595 EKVAQHRLMILATDMGSPALTGSAIVLVTVQDVNDNGPEFEAPYRPIVWENTIAP---QVIHMND 1656

  Fly  1341 SIVETTLLEPAARSELNIALPRATAEN---ISFPLERKEHVHKVKAAVAIDNEVFPFTLIAI--- 1399
            :   :|||.         |:.|.|:.|   .|..|            :.:.::|..|.|..:   
Zfish  1657 T---STLLH---------AIDRDTSSNGGPFSIRL------------LMLTSDVTNFNLTDMRNG 1697

  Fly  1400 SLVILILGTIGIIYICISWSKYKNF-KQRMRQY-------SSTNPPRYD----PVIVNQQ----- 1447
            |.:|..|               ::| :::.:||       .|.:||...    .||:..:     
Zfish  1698 SAMITAL---------------RSFDREQQKQYLLPILMIDSGSPPMSSTSTLTVIIGDKNDHPH 1747

  Fly  1448 ASSASETIA-NMK-EYETQMLAMAVPPDVDDDLQLDFSAKNHAFS---------LDNVSYITHKE 1501
            |...||.|. |:: ...|.:|.....||:|     |:|.|.:.|.         ..|...::.:|
Zfish  1748 APGHSEFIVYNIQGTLPTTVLGQVQSPDLD-----DWSEKVYKFEGKPPRQFILNQNNGQLSVRE 1807

  Fly  1502 NTNGGGQS------SPSHSDATTATIATLRRHKNLNNASMNNNLAINNRQNTFNRTLEMNTRNNA 1560
            .|..|..|      ..|..|.|::...|:   ..|...::.|..:|.....|.|.....:....:
Zfish  1808 GTAAGLYSLQVRVADKSWPDVTSSAEVTV---MELQEEALRNAASIRLANLTANEFFRASANEES 1869

  Fly  1561 NPLASPPNGALSGTLTLGRIKHQNSNHYQNGAYNID----PTGPNNMAH---------------- 1605
            ..:               |::...|..:|....|:|    .:|.....|                
Zfish  1870 RYM---------------RLRRLLSELFQTDVENVDVFSLASGRQPAQHHLSVWFAAHGSPYYKP 1919

  Fly  1606 AKNNAYSTMGRR------GNTFGDVGLLNGNGELMNATLGRNGQLNNRLYGGEVPIT 1656
            .|.:.|..|.:.      |.|...||:    .|.:.|..|:.|..::::...:.|.|
Zfish  1920 EKLHGYIAMHKAKLESALGVTILQVGV----DECVYAACGQTGGCSSKVTFSDTPTT 1972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad99CNP_733314.1 CA_like 68..140 CDD:481204 19/74 (26%)
Cadherin_repeat 146..259 CDD:206637 35/114 (31%)
Cadherin_repeat 280..383 CDD:206637 16/106 (15%)
Cadherin_repeat 393..496 CDD:206637 29/110 (26%)
Cadherin_repeat 518..594 CDD:206637 23/75 (31%)
Cadherin_repeat 608..699 CDD:206637 24/102 (24%)
Cadherin_repeat 710..802 CDD:206637 37/105 (35%)
Cadherin_repeat 814..903 CDD:206637 25/92 (27%)
Cadherin_repeat 915..1005 CDD:206637 21/90 (23%)
Cadherin_repeat 1041..1144 CDD:206637 23/112 (21%)
Cadherin_repeat 1159..1264 CDD:206637 26/140 (19%)
si:dkey-22o22.2XP_001921123.3 Cadherin_repeat 257..360 CDD:206637 3/7 (43%)
Cadherin_repeat 355..447 CDD:206637 22/96 (23%)
Cadherin_repeat 461..549 CDD:206637 34/109 (31%)
Cadherin_repeat 558..657 CDD:206637 21/121 (17%)
Cadherin_repeat 668..766 CDD:206637 29/112 (26%)
Cadherin_repeat 775..863 CDD:206637 25/91 (27%)
Cadherin_repeat 874..978 CDD:206637 25/103 (24%)
Cadherin_repeat 986..1093 CDD:206637 38/108 (35%)
Cadherin_repeat 1101..1194 CDD:206637 25/95 (26%)
Cadherin_repeat 1203..1302 CDD:206637 24/118 (20%)
Cadherin_repeat 1317..1416 CDD:206637 23/108 (21%)
Cadherin_repeat 1424..1524 CDD:206637 21/104 (20%)
Cadherin_repeat 1533..1630 CDD:206637 13/102 (13%)
Cadherin_repeat 1637..1745 CDD:206637 29/149 (19%)
Cadherin_repeat 1756..1836 CDD:206637 18/84 (21%)
EGF_CA 2003..2038 CDD:238011
LamG 2062..2223 CDD:214598
EGF_CA 2247..2281 CDD:238011
LamG 2312..2438 CDD:214598
EGF_CA 2512..2544 CDD:238011
CADH_Y-type_LIR 2700..2758 CDD:460041
Blue background indicates that the domain is not in the aligned region.

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