DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment neo and AgaP_AGAP004348

DIOPT Version :9

Sequence 1:	NP_651733.1	Gene:	neo / 43523	FlyBaseID:	FBgn0039704	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_001237516.3	Gene:	AgaP_AGAP004348 / 4577154	VectorBaseID:	AGAP004348	Length:	1804	Species:	Anopheles gambiae

Alignment Length:	734	Identity:	148/734 - (20%)
Similarity:	241/734 - (32%)	Gaps:	181/734 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EHLRIRRQAAESVTAAAPNASKVMASEEI----------KDKTEWPGA----KETSTEINRTERP 74
            :.|:...::.:.|.....:..::.|::|.          ||..|.|.:    |..|:.....:..
Mosquito   335 DQLKSSPKSPKGVNLVGDSVPEMKANDESSSIAASPKPGKDTIEQPNSTSKDKMNSSSTVLIDNG 399

  Fly    75 VENVETRN--SGFDLPAASDLSSSLGSEEDSIYYDNAPVDCNPELVGFEIVTGYVFSAPEKLMD- 136
            .|.:::.|  ||.:|     |.||:....|||      ::.|..:.....|.....|..|||..
Mosquito   400 TEAIDSSNNVSGIEL-----LESSVVEISDSI------MEANTSVKDTSSVANKSTSEGEKLSQS 453

  Fly   137 -SQPGTLMLTDCLD--TCRKNKTCQSVNYETGLCVLFSAHADQLPGALTKSQFPVFTIYAQKSCL 198
             ||......|..:|  :.||.:..:.:..||          ::|..|..||..       :....
Mosquito   454 WSQSVRRSATKGIDEFSVRKQEEQERLEEET----------EKLQKAPLKSPL-------KPRSP 501

  Fly   199 AVKPCSRAWYVDRVQNYKLKTE-------------------VKRTVSVAS--RRECFELCLGEND 242
            |.|..|....:|...:.:|:.|                   .:...|:||  |||     :.||:
Mosquito   502 AAKAASADESIDEDNDDELEDEEEAQDKNELLDDEAVEMEGYESGDSLASDLRRE-----MEENE 561

  Fly   243 FTCRSANYDRTSGACELSELDRLTLAGSQAFQVNDGSDYLENHCVDEPNKLCEFKRLPGRILK-T 306
            ...:..:.    |:.:..|.|      .|.....||:|.......||..:|.|     ..:|| |
Mosquito   562 IMDQGEDL----GSEDTEEND------EQEEDEEDGNDSWIVSSGDEAEQLNE-----DELLKDT 611

  Fly   307 VDSVYQEVSSIDECRELCLNSPYRCHSYDYNDTGDMVCRLSHHSRATLADVQEPFLEVPEASTYE 371
            .|...|..::..:.:|. ..:|.|....:..|..|...:.||..|...|           .|...
Mosquito   612 EDEDLQTKNASVKDKEK-TKTPKRRRIIEMVDDSDEDTKASHEERKETA-----------KSPKN 664

  Fly   372 LTSCYNVTIECGGGDMLARIRTSKL----FNGKVYAKGSPK-SCSVDVKSALDFELRMNYHDLEC 431
            |:|..::| ..||.:  ....|.||    .|..|..|...| :.:...|         |...:|.
Mosquito   665 LSSKRSLT-PVGGKE--NNTPTKKLNLSQINDAVKNKDQDKLANNTPTK---------NDTTMES 717

  Fly   432 NVRQSTAGRYVNDIIIQHHDMIVT-SSDLGLAL-ACQYDLTNKSVSNGVDLDVRGDIMPALSEEV 494
            :..:...|.  |:.::.......| |.|.|.|| :....|:|....||             .:||
Mosquito   718 STDEQPVGN--NETMLPATPAHKTPSKDTGAALHSATKSLSNSKHGNG-------------EKEV 767

  Fly   495 IVESPNVIMRITSRDGSDMMRSAEVGDPL------ALKFEIVDEQSPYEIFIRELVAMDGVDNSE 553
            ..|...   ..||.:...|.:.||.|...      |::.::...:||.:..|....:......:.
Mosquito   768 AAEDDE---NDTSGNSETMFQDAEDGGETVQKSDDAMEKDVSLSKSPTKSVIASRKSFPAASITT 829

  Fly   554 ITLIDSNGCPTDHFIMGPIYKGSVSGKMLLSNFDAFKFPSSEVVQFRALVTPCMPSCEPVQCEQE 618
            ..:|.....|.:..:...|...:..|.. .|..||.:  :.||.:..|||       |.|:.|..
Mosquito   830 KDVIGRKSLPANANMQAAIQSETDEGGE-SSQPDATQ--NDEVEEAEALV-------ENVEVENA 884

  Fly   619 DTSGEFRSLLSYGRKRRSLNTTDDHPRPRRDIDTSKKSAPSDMLLVQSIQITDKFGFKQDKQESG 683
            :...:.::      |......|.|.|.........:||.|:..|:                  |.
Mosquito   885 EHDDKTQA------KPAPAEFTLDQPADEAPTKPGRKSMPAVPLI------------------SA 925

  Fly   684 DFYDG--NETTFTANEEGH 700
            .||.|  .:......|:.|
Mosquito   926 QFYIGASKKRATIGGEDAH 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
neo	NP_651733.1	PAN_1	120..197	CDD:278453	17/80 (21%)
		PAN_AP_HGF	211..285	CDD:238532	17/94 (18%)
		PAN_1	294..373	CDD:278453	16/79 (20%)
		ZP	381..615	CDD:214579	51/246 (21%)
AgaP_AGAP004348	XP_001237516.3	PHA03307	8..>298	CDD:223039
		PRK08581	672..>913	CDD:236304	57/286 (20%)
		PTZ00121	<1186..>1487	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900